Results 221 to 230 of about 3,028,894 (317)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Prognostic value of anoikis- and epithelial-mesenchymal transition-related genes and development of a prognostic risk model in thyroid cancer. [PDF]

Discov Oncol
Xiang KF, Wang L, Wu Y, Zhang D.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Key predictors of 30-day mortality in non-cardiac surgery: development, key risk factors, and calibration of a risk model. [PDF]

Front Med (Lausanne)
Saetang M, Kunapaisal T, Limvatanalert S, Sukitpaneenit K, Saelim K, Yongsata D, Muangsong O, Bunkerd M, Kampeng S.   +8 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Development of the MSKP index: Risk model of musculoskeletal pain in Colombian adolescents. [PDF]

PLoS One
Alfonso-Mora ML, Sánchez-Vera MA, Uribe-Laverde MA, García Becerra AM, Gonzalez PS.   +4 more
europepmc   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

PANoptosis-related gene clusters and prognostic risk model in clear cell renal cell carcinoma. [PDF]

Front Genet
Zhao Q, Xie H, Li C, Xiong Y, Fan Y, Huang Y, Zhan Y, Zeng S.   +7 more
europepmc   +1 more source

The use of modelling and probabilistic methods in cumulative risk assessment

, 2008
Sieto Bosgra
openalex   +1 more source

Modelling of Supply Chain Risk Contagion Based on System Dynamics

, 2019
Dingfu Jiang, Caihong Liu
openalex   +2 more sources