Results 201 to 210 of about 1,468,611 (306)

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Key research priorities in methodological approaches for measuring the exposome and studying its role in the development of dementia. [PDF]

Alzheimers Dement
Nichols E, Keller KP, Chang H, Chiang YY, Gross AL, Hayes-Larson E, Claus Henn B, Kezios KL, Meijer E, Shih RA, Szpiro AA, Weiss J, Weuve J, Adar SD, Lee J.   +14 more
europepmc   +1 more source

National Multisectoral HIV Prevention Strategy 2009-2012:Towards Achieving Tanzania Without HIV [PDF]

, 2009
The United Republic of Tanzania, (URT)
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Blockchain consensus mechanism and method for peer-to-peer electricity trading. [PDF]

Sci Rep
Wang N, Chen Y, Zhai F, Li B.
europepmc   +1 more source

Actions for education and childcare settings to prepare for wider opening from 1 June 2020 : updated 12 May 2020 [PDF]

, 2020

core  

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

Setting the UK research priorities for hypertension using a modified Delphi approach: a British and Irish Hypertension Society Initiative with Support from the British Heart Foundation Clinical Research Collaborative. [PDF]

J Hypertens
Swift PA, Arnold A, Heagerty A, McNally R, Nadar S, Shantsila E, Stables R, Thomas NG, Sinha M, Thakkar R, Warren HR, Watts M, Dasgupta I.   +12 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Insights on the implementation strategies for a potential new tuberculosis vaccine in South Africa. [PDF]

PLOS Glob Public Health
Thomas KA, Okoro C, Ntshiqa T, Damovsky V, Goldberg D, Ramokhoase O, Clark RA, Jassat W, Churchyard GJ, Abdullah F, Kubjane M, Seeley J, Charalambous S, White RG.   +13 more
europepmc   +1 more source