Results 161 to 170 of about 17,508,447 (350)

Drought propagation as a nonlinear amplifier of ecohydrological damage

open access: yesCommunications Earth & Environment
Meteorological drought can propagate to soil and ecological droughts, triggering cascading disruptions in ecosystem functioning. However, whether the ecohydrological damage—the sum of standardized vegetation greenness and soil moisture losses—is ...
Zhuoran Qu   +7 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Risk reduction in kidney surgery

open access: yesAnnals of Translational Medicine, 2019
Partial nephrectomy has become a cornerstone of kidney cancer surgery. Several studies have shown at least equivalent oncologic results of partial and radical nephrectomy (1,2). The preservation of functioning kidney parenchyma is thought to reduce the risk of developing comorbidities such as chronic kidney failure, thereby potentially improving ...
openaire   +2 more sources

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

‘Resettlement is worthwhile for our children’s future’: reflections from the Stateless Rohingya refugees in Malaysia

open access: yesComparative Migration Studies
Resettlement to a third country offers a durable solution for refugees who cannot integrate into their asylum or transit countries. While most studies focus on the experiences of refugees after their arrival in resettlement countries or on the political ...
Patrícia Nabuco Martuscelli   +2 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

Association Between Lowering LDL-C and Cardiovascular Risk Reduction Among Different Therapeutic Interventions: A Systematic Review and Meta-analysis.

open access: yesJournal of the American Medical Association (JAMA), 2016
Michael G. Silverman   +7 more
semanticscholar   +1 more source

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