Results 171 to 180 of about 17,508,447 (350)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Vectorized building rooftop prints of the Qinghai-Tibetan Plateau and its neighboring regions
Scientific DataLarge-scale high-precision building distribution data is important fundation for regional urban planning and resource allocation and disaster risk research. The Qinghai-Tibetan Plateau is the third pole of the world.
Tao Ye +8 more
doaj +1 more source
Insurance and deliberation as drought disaster risk reduction strategies [PDF]
As the international community is moving from response to disaster risk reduction, it becomes imperative to take the whole risk chain into consideration, from prevention to rehabilitation of a droughtstricken area.
Topcu, S., Warner, J.F.
core +2 more sources
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
ASSESSING THE RISKS OF A FUTURE RAPID LARGE SEA LEVEL RISE: A REVIEW [PDF]
Our aim is to make an appropriate characterization and interpretation of the risk problem of rapid large sea level rise that reflects the very large uncertainty in present day knowledge concerning this possibility, and that will be useful in informing ...
Clark L. Goble +2 more
core
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Resource capability for local government in mainstreaming gender into sustainable post disaster reconstruction : Evidence from Bantul Indonesia [PDF]
Understanding how local government responds to gender vulnerability and gender capacity is important to make cities safer both for women and for men.
Amaratunga, Dilanthi, Yumarni, Tri
core
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source