Results 151 to 160 of about 1,380,859 (329)

MCA4climate: A Practical Framework for Planning Pro-Development Climate Policy [PDF]

, 2011
MCA4climate is a major new UNEP initiative providing 1 Introduction practical assistance to governments in preparing their climate change mitigation and adaptation plans and strategies.
Bristow, Sophy, Puig, Daniel, Scrieciu, Şerban   +2 more
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Mass Customization in Wireless Communication Services: Individual Service Bundles and Tariffs [PDF]

This paper presents results on mass customization of wireless communications services and tariffs. It advocates for a user-centric view of wireless service configuration and pricing as opposed to present-day service catalog options.
Chen, H., Pau, L-F.
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Assessing nature-based coastal defense

Scientific Reports
Nature-based Coastal Defense is increasingly used to reduce climate risk, because considered effective, inexpensive and cost-effective, easy to implement, and no-regrets.
Virginie K. E. Duvat, Inès Hatton, Louise Burban, Alice Jacobée, Myriam Vendé-Leclerc, Lucile Stahl   +5 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Evidence review: options analysis for a regional climate change programme to deliver more effective climate services, early warning and disaster risk reduction

, 2015
G Vellingiri, Kamta Prasad, Stephen Wade, Darren Lumbroso, Tim Oakley, K. R. Viswanathan, Sumit Dugar, Lindsay C. Dahora, Reetu Sogani   +8 more
openalex   +2 more sources

Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference [PDF]

, 2011
Paulus Kirchhof, Gregory Y. H. Lip, Isabelle C. Van Gelder, Jeroen J. Bax, Elaine M. Hylek, Stefan Kääb, Ulrich Schotten, K Wegscheider, Giuseppe Boriani, Axel Brandes, M. D. Ezekowitz, Hans‐Christoph Diener, Laurent Haegeli, H. Heidbuchel, Deirdre A. Lane, Lluı́s Mont, Stefan M. Willems, Paul Dorian, Maria Aunes-Jansson, Carina Blomström‐Lundqvist, Maria Borentain, Stefanie Breitenstein, Martina Brueckmann, Nilo B. Cater, Andreas Clemens, Dobromir Dobrev, Sérgio Dubner, Nils Edvardsson, Leif Friberg, A. Goette, Michele Massimo Gulizia, Róbert Hatala, Jeremy Horwood, Łukasz Szumowski, Lukas Kappenberger, Josef Kautzner, Angelika Leute, Trudie Lobban, Ralf Meyer, J. Millerhagen, John M. Morgan, Felix Muenzel, Michael Näbauer, C. Baertels, M. Oeff, Dalibor Paar, Juergen Polifka, Ursula Ravens, Ludger Rosin, Wim Stegink, Gerhard Steinbeck, Panos Vardas, A. Vincent, Maggie C. Walter, G. Breithardt, A. John Camm   +55 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source