Results 91 to 100 of about 11,478,693 (361)

Polygenic risk scores in epilepsy

Medizinische Genetik, 2022
Abstract An epilepsy diagnosis has large consequences for an individual but is often difficult to make in clinical practice. Novel biomarkers are thus greatly needed. Here, we give an overview of how thousands of common genetic factors that increase the risk for epilepsy can be summarized as epilepsy polygenic risk scores (PRS).
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Comprehensive analysis of palmitoylation-related proteins for prognostic risk evaluation and tumor immune microenvironment assessment in glioma

Frontiers in Immunology
BackgroundGlioma is one of the most common tumors, characterized by a high incidence rate and mortality, posing a formidable global health challenge. Palmitoylation represents a significant post-translational modification that holds a pivotal role in the
Jihao Xue, Li Lin, Chang Liu, Qijia Yin, Tao Wang, Rui Lai, Ligang Chen, Yiran Yin, Ming Wang, Jie Zhou   +9 more
doaj   +1 more source

MARS: Mutation-Adjusted Risk Score for Advanced Systemic Mastocytosis

Journal of Clinical Oncology, 2019
PURPOSE To develop a risk score for patients with advanced systemic mastocytosis (AdvSM) that integrates clinical and mutation characteristics. PATIENTS AND METHODS The study included 383 patients with AdvSM from the German Registry on Disorders of ...
M. Jawhar, J. Schwaab, I. Alvarez-Twose, Khalid Shoumariyeh, N. Naumann, J. Lübke, C. Perkins, J. Muñoz-González, M. Meggendorfer, Vanessa E. Kennedy, G. Metzgeroth, A. Fabarius, D. Pfeifer, K. Sotlar, H. Horny, N. von Bubnoff, T. Haferlach, N. Cross, W. Hofmann, W. Sperr, A. García-Montero, P. Valent, J. Gotlib, A. Órfão, A. Reiter   +24 more
semanticscholar   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Ten Years Risk Prediction of a Major Cardiovascular Event in a Rural Block in Tamil Nadu

Heart India, 2015
Background: India has a high burden of cardiovascular diseases (CVDs). High-risk interventions can be initiated only when individuals at high-risk have been identified.
Logaraj Muthunarayanan, John Kamala Russel, Shailendra Kumar Hegde, Balaji Ramraj   +3 more
doaj   +1 more source

Performance of polygenic risk scores for cancer prediction in a racially diverse academic biobank [PDF]

, 2021
Louise Wang, Heena Desai, Shefali S. Verma, Anh N. Le, Ryan Hausler, Anurag Verma, Renae Judy, Abigail Doucette, Peter Gabriel, Katherine L. Nathanson, Scott M. Damrauer, Danielle L. Mowery, Marylyn D. Ritchie, Rachel L. Kember, Kara N. Maxwell   +14 more
openalex   +1 more source

Development of a Risk Score to Predict Postoperative Delirium in Patients With Hip Fracture.

Anesthesia and Analgesia, 2019
BACKGROUND Post-hip fracture surgery delirium (PHFD) is a significant clinical problem in older patients, but an adequate, simple risk prediction model for use in the preoperative period has not been developed.
Eun Mi Kim, Guohua Li, Minjae Kim
semanticscholar   +1 more source

Risk stratification of patients admitted to hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: development and validation of the 4C Mortality Score

British medical journal, 2020
Objective To develop and validate a pragmatic risk score to predict mortality in patients admitted to hospital with coronavirus disease 2019 (covid-19). Design Prospective observational cohort study.
S. Knight, A. Ho, R. Pius, I. Buchan, G. Carson, T. Drake, J. Dunning, C. Fairfield, C. Gamble, C. A. Green, Rishi K. Gupta, S. Halpin, H. Hardwick, K. Holden, P. Horby, C. Jackson, K. McLean, L. Merson, J. Nguyen-Van-Tam, Lisa Norman, M. Noursadeghi, P. Olliaro, M. Pritchard, C. Russell, Catherine A Shaw, Aziz Sheikh, Tommy Solomon, C. Sudlow, O. Swann, L. Turtle, P. Openshaw, J. Baillie, M. Semple, A. Docherty, E. Harrison, J. Baillie, M. Semple, P. Openshaw, G. Carson, B. Alex, Benjamin Bach, W. Barclay, D. Bogaert, M. Chand, Graham S. Cooke, A. Docherty, J. Dunning, A. da Silva Filipe, T. Fletcher, C. A. Green, E. Harrison, J. Hiscox, A. Ho, P. Horby, S. Ijaz, S. Khoo, P. Klenerman, Andrew Law, W. Lim, A. Mentzer, L. Merson, A. Meynert, M. Noursadeghi, S. Moore, M. Palmarini, W. Paxton, G. Pollakis, NicholasS . C. Price, A. Rambaut, David L. Robertson, C. Russell, V. Sancho-Shimizu, J. Scott, L. Sigfrid, Tommy Solomon, S. Sriskandan, D. Stuart, C. Summers, R. Tedder, E. Thomson, R. Thwaites, L. Turtle, M. Zambon, H. Hardwick, C. Donohue, Jane Ewins, W. Oosthuyzen, Fiona Griffiths, Lisa Norman, R. Pius, Tom M. Drake, C. Fairfield, S. Knight, K. McLean, D. Murphy, Catherine A Shaw, J. Dalton, M. Girvan, Eglė Savičiūtė, S. Roberts, Janet R Harrison, Laura Marsh, M. Connor, S. Halpin, C. Jackson, C. Gamble, G. Leeming, Ross Hendry, James Scott-Brown, W. Greenhalf, V. Shaw, Sarah E. McDonald, K. Ahmed, J. Armstrong, M. Ashworth, I. G. Asiimwe, S. Bakshi, S. Barlow, Laura Booth, B. Brennan, K. Bullock, Benjamin W. A. Catterall, Jordan J. Clark, Emily Clarke, Sarah J. Cole, L. Cooper, H. Cox, Christopher Davis, Oslem Dincarslan, Chris Dunn, P. Dyer, A. Elliott, A. Evans, Lewis W. S. Fisher, T. Foster, Isabel García-Dorival, W. Greenhalf, P. Gunning, Catherine Hartley, A. Ho, R. L. Jensen, Christopher Jones, T. R. Jones, Shadia Khandaker, K. King, Robyn T Kiy, Chrysa Koukorava, Annette Lake, S. Lant, D. Latawiec, L. Lavelle-Langham, Daniella Lefteri, Lauren Lett, Lucia A. Livoti, Maria Mancini, L. McEvoy, J. Mclauchlan, Soeren Metelmann, N. Miah, J. Middleton, Joyce Mitchell, E. Murphy, R. Penrice-Randal, J. Pilgrim, T. Prince, W. Reynolds, P. Ridley, Debby Sales, V. Shaw, R. Shears, B. Small, Krishanthi S Subramaniam, Agnieska Szemiel, Aislynn Taggart, Jolanta Tanianis-Hughes, Jordan Thomas, E. Trochu, Libby van Tonder, Eve Wilcock, J. E. Zhang, K. Adeniji, D. Agranoff, K. Agwuh, D. Ail, A. Alegria, Brian Angus, A. Ashish, Doug Atkinson, S. Bari, G. Barlow, S. Barnass, Nicholas A. Barrett, C. Bassford, D. Baxter, M. Beadsworth, J. Bernatoniene, J. Berridge, N. Best, P. Bothma, D. Brealey, R. Brittain-Long, N. Bulteel, Thomas G Burden, A. Burtenshaw, Vikki Caruth, D. Chadwick, D. Chambler, Nigel Chee, J. Child, S. Chukkambotla, Tom Clark, P. Collini, Catherine Cosgrove, J. Cupitt, Maria-Teresa Cutino-Moguel, P. Dark, Chris Dawson, S. Dervisevic, P. Donnison, S. Douthwaite, I. DuRand, A. Dushianthan, Tristan Dyer, C. Evans, C. Eziefula, C. Fegan, A. Finn, D. Fullerton, S. Garg, A. Garg, J. Godden, A. Goldsmith, Clive Graham, E. Hardy, S. Hartshorn, D. Harvey, P. Havalda, D. Hawcutt, M. Hobrok, L. Hodgson, Anita Holme, A. Hormis, M. Jacobs, Susan Jain, P. Jennings, A. Kaliappan, V. Kasipandian, S. Kegg, Michael R. Kelsey, J. Kendall, C. Kerrison, I. Kerslake, O. Koch, G. Koduri, G. Koshy, S. Laha, Susan G. Larkin, T. Leiner, P. Lillie, James Limb, V. Linnett, J. Little, M. MacMahon, E. Macnaughton, Ravish Mankregod, Huw Masson, E. Matovu, K. McCullough, R. Mcewen, M. Meda, G. Mills, J. Minton, M. Mirfenderesky, K. Mohandas, Quen Mok, J. Moon, Elinoor Moore, P. Morgan, C. Morris, Katherine Mortimore, S. Moses, Mbiye A Mpenge, Rohinton Mulla, Michael J. Murphy, Megan L. Nagel, T. Nagarajan, M. Nelson, I. Otahal, M. Pais, S. Panchatsharam, Hassan Paraiso, B. Patel, J. Pepperell, M. Peters, M. Phull, S. Pintus, J. Pooni, F. Post, D. Price, R. Prout, N. Rae, H. Reschreiter, Tim Reynolds, Neil Richardson, M. Roberts, D. Roberts, A. Rose, G. Rousseau, Brendan J. Ryan, Taranprit Saluja, A. Shah, Prad Shanmuga, Anil Sharma, A. Shawcross, J. Sizer, Richard Smith, C. Snelson, N. Spittle, N. Staines, T. Stambach, R. Stewart, P. Subudhi, T. Szakmany, K. Tatham, Jordan Thomas, C. Thompson, Robert Thompson, A. Tridente, D. Tupper-Carey, M. Twagira, A. Ustianowski, N. Vallotton, L. Vincent-Smith, Shico Visuvanathan, A. Vuylsteke, S. Waddy, R. Wake, A. Walden, I. Welters, T. Whitehouse, P. Whittaker, A. Whittington, M. Wijesinghe, Martin Williams, Lawrence Wilson, Sarah Wilson, S. Winchester, M. Wiselka, A. Wolverson, D. Wooton, A. Workman, B. Yates, Peter Young   +352 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source