Results 101 to 110 of about 11,478,693 (361)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Cardiovascular risk factors in 7-13 years old children from Vojvodina (Serbia) [PDF]

Journal of Medical Biochemistry, 2016
Background: Atherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia.
Dželajlija Darko D., Spasić Slavica S., Kotur-Stevuljević Jelena M., Bogavac-Stanojević Nataša B.   +3 more
doaj  

Machine Learning to Predict the Risk of Incident Heart Failure Hospitalization Among Patients With Diabetes: The WATCH-DM Risk Score

Diabetes Care, 2019
OBJECTIVE To develop and validate a novel, machine learning–derived model to predict the risk of heart failure (HF) among patients with type 2 diabetes mellitus (T2DM).
Matthew W. Segar, M. Vaduganathan, Kershaw V. Patel, D. McGuire, J. Butler, G. Fonarow, Mujeeb A. Basit, V. Kannan, J. Grodin, Brendan M. Everett, D. Willett, J. Berry, A. Pandey   +12 more
semanticscholar   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Challenging the Paradigm: Long-Term Outcomes in Dialysis-Dependent Patients Undergoing CABG

Journal of Cardiovascular Development and Disease
Dialysis-dependent (DD) patients undergoing coronary artery bypass grafting (CABG) remain a particularly high-risk population with impaired outcomes despite advances in surgical techniques.
Ezin Deniz, Tonita Brunkhorst, Florian Helms, Jasmin Hanke, Ali Merzah, Sadeq Ali-Hasan Al-Saegh, Alina Zubarevich, Felix Fleissner, Issam Ismail, Gregor Warnecke, Günes Dogan, Jan Dieter Schmitto, Bastian Schmack, Alexander Weymann, Arjang Ruhparwar, Aron-Frederik Popov   +15 more
doaj   +1 more source

Penerapan Metode Job Safety Analysis and Risk Score untuk Meningkatkan Keselamatan dan Kesehatan Kerja pada Departemen Printing, Sewing dan Assembly PT. PAI, Bandung (Suatu Pendekatan Participatory Ergonomic)

Jurnal Kesehatan, 2018
The footwear industry problem lies in the working environment and facilities that do not meet the standards for the health and safety of workers, necessary improvements must be made.
Paulus Sukapto, Harjoto Djojosubroto, Handy Permana   +2 more
doaj   +1 more source

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke

Nature Communications, 2019
Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors.
Gad Abraham, R. Malik, Ekaterina Yonova-Doing, Agus Salim, Tingting Wang, J. Danesh, A. Butterworth, J. Howson, M. Inouye, M. Dichgans   +9 more
semanticscholar   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

New electrocardiographic score for the prediction of atrial fibrillation: The MVP ECG risk score (morphology‐voltage‐P‐wave duration)

Annals of Noninvasive Electrocardiology, 2019
Atrial fibrillation (AF) is the most common arrhythmia and has significant morbidity. A score composed of easily measured electrocardiographic variables to identify patients at risk of AF would be of great value in order to stratify patients for ...
B. Alexander, Julia Milden, Bachar Hazim, Sohaib Haseeb, A. Bayés‐Genís, R. Elosúa, M. Martínez‐Sellés, C. Yeung, W. Hopman, A. Bayés de Luna, A. Baranchuk   +10 more
semanticscholar   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source