Results 181 to 190 of about 11,478,693 (361)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

IHD risk score. [PDF]

Circulation, 1980
H S, Rosman, B A, Blumenstein
openaire   +2 more sources

PB1015 Venous Thromboembolism in Patients with Newly Diagnosed Lymphoma and Its Association with ThroLy and Khorana Risk Scores

, 2023
W. Wan Mohd Zohdi, Sivakumar Palaniappan, C. Guang Yong, Wonjae Lee, Nor Rafeah Tumian   +4 more
openalex   +1 more source

A Cardiovascular Risk Score for Use in Occupational Medicine [PDF]

, 2021
Giuseppina Affinito, Pasquale Arpaïa, Francesco Barone‐Adesi, Luca Fontana, Raffaele Palladino, Maria Triassi   +5 more
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Risk score roulette: A cautionary tale of polygenic risk score reliability. [PDF]

J Alzheimers Dis
Xue D, Blue EE, Wood AC, Rotter JI, Fohner AE.   +4 more
europepmc   +1 more source

Personalized Risk Scoring for Critical Care Prognosis using Mixtures of Gaussian Processes [PDF]

, 2016
Ahmed M. Alaa, Jinsung Yoon, Scott Hu, Mihaela van der Schaar   +3 more
openalex   +1 more source

Predicting Survival in Patients With Pulmonary Arterial Hypertension: The REVEAL Risk Score Calculator 2.0 and Comparison With ESC/ERS-Based Risk Assessment Strategies.

Chest, 2019
R. Benza, M. Gomberg-Maitland, C. G. Elliott, H. Farber, A. Foreman, A. Frost, M. McGoon, D. Pasta, M. Selej, C. Burger, R. Frantz   +10 more
semanticscholar   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in European Hypertensive Adults. [PDF]

J Cardiovasc Dev Dis
Shen S, Wang Y, Hu YQ.
europepmc   +1 more source