Results 191 to 200 of about 8,656,301 (259)

Alzheimer's disease polygenic risk score associates with hippocampal subfield atrophy and immune-related genetic mechanism. [PDF]

Front Aging Neurosci
Olivé C, de Rojas I, Zhang L, Sotolongo-Grau O, Quintela I, García-González P, Puerta R, Montrreal L, Bayón P, Rovira M, Valenzuela A, Capdevila-Bayo M, Muñoz Á, Miguel A, Calm B, Calero M, Rábano A, Belén Pastor A, Del Ser T, Medina M, Carracedo Á, Ramírez A, Molina-Porcel L, Montalbán X, Cano A, Valero S, Marquié M, Sanz P, Sánchez-Juan P, Boada M, Strange B, Fernández MV, Ruiz A.   +32 more
europepmc   +1 more source

Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants

Annals of Clinical and Translational Neurology, EarlyView.
Multiple Sclerosis Relapse Activity After Ozanimod Discontinuation in DAYBREAK Trial Participants. ABSTRACT Objective Return of disease activity is expected when patients discontinue disease‐modifying therapy (DMT) for multiple sclerosis (MS). Some MS DMTs are associated with higher‐than‐expected disease activity (rebound) after discontinuation.
Ralf Gold, Krzysztof W. Selmaj, Regina Berkovich, Jeffrey A. Cohen, Giancarlo Comi, Eva K. Havrdová, James K. Sheffield, Hetal Desai, Chun‐Yen Cheng, Jon V. Riolo, Andrew Thorpe, Erik DeBoer, Bruce A. C. Cree   +12 more
wiley   +1 more source

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change. [PDF]

Genome Med
Lu T, Stalter LN, Lauer KV, Hanlon BM, Zhang W, Funk LM.   +5 more
europepmc   +1 more source

The Role of Calcitonin Gene‐Related Peptide in High‐Altitude Headache: A Prospective Field Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐altitude headache (HAH) is a common neurological condition associated with rapid ascent to high altitude. The pathophysiological mechanisms underlying HAH remain incompletely understood. Calcitonin gene‐related peptide (CGRP), a neuropeptide implicated in migraine pathophysiology, may play a key role in the pathophysiology of ...
Roman Schniepp, Ludwig Karrasch, Helena Breitenstein, Andreas Straube, Katharina Kamm   +4 more
wiley   +1 more source

Risk score roulette: A cautionary tale of polygenic risk score reliability. [PDF]

J Alzheimers Dis
Xue D, Blue EE, Wood AC, Rotter JI, Fohner AE.   +4 more
europepmc   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

Multidimensional Structural Echocardiographic Patterns and Risk Score for Prognostic Stratification in Ischemic Cardiomyopathy. [PDF]

J Clin Med
Tang R, Xu Y, Zong X, Pan R, Jia S, Xi R, Tao R, Fan Q.   +7 more
europepmc   +1 more source

High‐Resolution MRI Revealed Different Etiology‐Specific Associations With Cerebral Infarction in Adult Moyamoya Vasculopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective High‐resolution MRI enables detailed assessment of intracranial vessel wall pathology in moyamoya vasculopathy. We aimed to classify adult moyamoya vasculopathy etiologies using high‐resolution MRI and to examine subtype‐specific associations between high‐resolution MRI features and ischemic infarction.
Guangsong Han, Jiachun Pan, Yuehui Hong, Xiaoyuan Fan, Ming Yao, Lixin Zhou, Yicheng Zhu, Feng Feng, Jun Ni   +8 more
wiley   +1 more source

Development and Validation of a Clinical Prognostic Risk Score for Stillbirth in Ethiopia: A Cohort Study Using PMA Data. [PDF]

Health Sci Rep
Mulugeta C, Emagneneh T, Susu B, Yetwale A, Yesuf A, Bililign Yimer N, Alamrew A.   +6 more
europepmc   +1 more source