Results 11 to 20 of about 11,478,693 (361)

Development and Validation of a Clinical Risk Score to Predict the Occurrence of Critical Illness in Hospitalized Patients With COVID-19.

JAMA Internal Medicine, 2020
Importance Early identification of patients with novel corona virus disease 2019 (COVID-19) who may develop critical illness is of great importance and may aid in delivering proper treatment and optimizing use of resources.
W. Liang, Hengrui Liang, Limin Ou, Binfeng Chen, Ailan Chen, Caichen Li, Yimin Li, W. Guan, L. Sang, Jiatao Lu, Yuan-da Xu, Guoqiang Chen, Haiyan Guo, Jun Guo, Zisheng Chen, Yi Zhao, Shiyue Li, Nuofu Zhang, N. Zhong, Jianxing He   +19 more
semanticscholar   +1 more source

A Risk Score to Detect Subclinical Rheumatoid Arthritis–Associated Interstitial Lung Disease

Arthritis & Rheumatology, 2022
Patients at high risk of rheumatoid arthritis–associated interstitial lung disease (RA‐ILD) would benefit from being identified before the onset of respiratory symptoms; this can be done by screening patients with the use of chest high‐resolution ...
Pierre-Antoine Juge, B. Granger, M. Debray, E. Ebstein, F. Louis-Sidney, J. Kędra, T. Doyle, R. Borie, A. Constantin, B. Combe, R. Flipo, X. Mariette, O. Vittecoq, A. Saraux, G. Carvajal Alegria, J. Sibilia, F. Berenbaum, C. Kannengiesser, C. Boileau, J. Sparks, B. Crestani, B. Fautrel, P. Dieudé   +22 more
semanticscholar   +1 more source

Development of a clinical polygenic risk score assay and reporting workflow

Nature Medicine, 2022
Implementation of polygenic risk scores (PRS) may improve disease prevention and management but poses several challenges: the construction of clinically valid assays, interpretation for individual patients, and the development of clinical workflows and ...
Limin Hao, P. Kraft, G. Berriz, Elizabeth D. Hynes, C. Koch, Prathik Korategere V Kumar, Shruti S Parpattedar, Marcie A. Steeves, Wanfeng Yu, Ashley A. Antwi, Charles A. Brunette, Morgan E. Danowski, M. Gala, Robert C. Green, Natalie E. Jones, A. Lewis, S. Lubitz, P. Natarajan, J. Vassy, Matthew S. Lebo   +19 more
semanticscholar   +1 more source

Tutorial: a guide to performing polygenic risk score analyses

bioRxiv, 2018
A polygenic score (PGS) or polygenic risk score (PRS) is an estimate of an individual’s genetic liability to a trait or disease, calculated according to their genotype profile and relevant genome-wide association study (GWAS) data.
S. Choi, Timothy Shin Heng Mak, P. O’Reilly   +2 more
semanticscholar   +2 more sources

A novel prognostic tool to predict mortality in patients with atrial fibrillation: The BASIC-AF risk scoreKey messages

Hellenic Journal of Cardiology, 2021
Background: This study sought to develop and validate a risk score to predict mortality in patients with atrial fibrillation (AF) after a hospitalization for cardiac reasons.
Athanasios Samaras, Anastasios Kartas, Evangelos Akrivos, George Fotos, George Dividis, Dimitra Vasdeki, Eleni Vrana, Georgios Rampidis, Haralambos Karvounis, George Giannakoulas, Apostolos Tzikas   +10 more
doaj   +1 more source

Polygene Risk Scores

Philosophy of Medicine, 2023
This paper explores the interpretation and use of polygenic risk scores (PRSs). We argue that PRSs generally do not directly embody causal information. Nonetheless, they can assist us in tracking other causal relationships concerning genetic effects.
James Woodward, Kenneth Kendler
openaire   +3 more sources

A polygenic risk score predicts atrial fibrillation in cardiovascular disease.

European Heart Journal, 2022
AIMS Interest in targeted screening programmes for atrial fibrillation (AF) has increased, yet the role of genetics in identifying patients at highest risk of developing AF is unclear.
N. Marston, Amanda C Garfinkel, Frederick K. Kamanu, G. Melloni, C. Roselli, P. Jarolím, D. Berg, Deepak L. Bhatt, Marc P. Bonaca, C. Cannon, R. Giugliano, M. O’Donoghue, I. Raz, B. Scirica, E. Braunwald, D. Morrow, P. Ellinor, S. Lubitz, M. Sabatine, C. Ruff   +19 more
semanticscholar   +1 more source

A Novel DNA Replication-Related Signature Predicting Recurrence After R0 Resection of Pancreatic Ductal Adenocarcinoma: Prognostic Value and Clinical Implications

Frontiers in Cell and Developmental Biology, 2021
The aim of any surgical resection for pancreatic ductal adenocarcinoma (PDAC) is to achieve tumor-free margins (R0). R0 margins give rise to better outcomes than do positive margins (R1).
Zengyu Feng, Zengyu Feng, Zengyu Feng, Kexian Li, Kexian Li, Jianyao Lou, Mindi Ma, Yulian Wu, Chenghong Peng, Chenghong Peng   +9 more
doaj   +1 more source

Development and validation of composite risk score to assess risks of major noncommunicable diseases in Northern Indian populations: A research protocol

International Journal of Noncommunicable Diseases, 2020
Background: Noncommunicable diseases (NCDs) which mainly consist of cardiovascular diseases, diabetes, cancer, and chronic respiratory diseases account for 38 million deaths out of the 56 million deaths globally and 54% of healthy life years lost in 2012.
Ria Nangia, J S Thakur, Anil Kumar Bhalla, Ajay Duseja   +3 more
doaj   +1 more source

Identification of Risk Factors and Development of Predictive Risk Score Model for Mortality after Open Ruptured Abdominal Aortic Aneurysm Repair

Medicina, 2022
Background and Objectives: Despite the relatively large number of publications concerning the validation of these models, there is currently no solid evidence that they can be used with absolute precision to predict survival. The goal of this study is to
Ivan Tomic, Petar Zlatanovic, Miroslav Markovic, Milos Sladojevic, Perica Mutavdzic, Ranko Trailovic, Ksenija Jovanovic, David Matejevic, Biljana Milicic, Lazar Davidovic   +9 more
doaj   +1 more source