Results 21 to 30 of about 11,478,693 (361)

Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs a Clinical Risk Score for Coronary Artery Disease.

Journal of the American Medical Association (JAMA), 2020
Importance The incremental value of polygenic risk scores in addition to well-established risk prediction models for coronary artery disease (CAD) is uncertain. Objective To examine whether a polygenic risk score for CAD improves risk prediction beyond
J. Elliott, B. Bodinier, T. Bond, M. Chadeau-Hyam, E. Evangelou, K. Moons, A. Dehghan, D. Muller, P. Elliott, I. Tzoulaki   +9 more
semanticscholar   +1 more source

Genetic Risk Scores

Current Protocols in Human Genetics, 2019
AbstractGenome‐wide variation data with millions of genetic markers have become commonplace. However, the potential for interpretation and application of these data for clinical assessment of outcomes of interest, and prediction of disease risk, is currently not fully realized.
Robert P, Igo, Tyler G, Kinzy, Jessica N, Cooke Bailey   +2 more
openaire   +3 more sources

PRSice: Polygenic Risk Score software [PDF]

Bioinformatics, 2014
Abstract Summary: A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS ...
Euesden, Jack, Lewis, Cathryn M, O'Reilly, Paul F   +2 more
openaire   +5 more sources

PRSice-2: Polygenic Risk Score software for biobank-scale data

GigaScience, 2019
Background Polygenic risk score (PRS) analyses have become an integral part of biomedical research, exploited to gain insights into shared aetiology among traits, to control for genomic profile in experimental studies, and to strengthen causal inference,
S. Choi, P. O’Reilly
semanticscholar   +1 more source

Validity of TIMI Risk Score and HEART Score for Risk Assessment of Patients with Unstable Angina/Non-ST Elevation Myocardial Infarction Presented to an Emergency Department in Jordan

Open Access Emergency Medicine, 2023
Muhannad J Ababneh,1 Mahmoud Mustafa Smadi,2 Abdullah Al-Kasasbeh,1 Qutaiba Ali Jawarneh,3 Mohammad Nofal,3 Mohanad El-Bashir,4 Mohamad Ismail Jarrah,1 Liqaa A Raffee5 1Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Jordan ...
Ababneh MJ, Smadi MM, Al-Kasasbeh A, Jawarneh QA, Nofal M, El-Bashir M, Jarrah MI, Raffee LA   +7 more
doaj  

Development of a prognostic model for children with neuroblastoma based on necroptosis-related genes

Frontiers in Genetics, 2022
Background: Neuroblastoma (NBL) is a rare malignant tumor of the peripheral sympathetic nervous system in children with a low overall survival rate. Recent studies have revealed the important role of necroptosis in the occurrence and development of many ...
Jing Chu
doaj   +1 more source

Host susceptibility to severe COVID-19 and establishment of a host risk score: findings of 487 cases outside Wuhan

Critical Care, 2020
No abstract available Keywords: COVID-2019; Disease severity; Host susceptibility; Risk factors.
Yu Shi, Xia Yu, Hong Zhao, Hao Wang, Ruihong Zhao, J. Sheng   +5 more
semanticscholar   +1 more source

Adapting Diabetes Risk Scores for Jordan

International Journal of General Medicine, 2021
Amjad Al Shdaifat,1 Yousef Khader,2 Muwafag Al Hyari,3 Omar Shatnawi,1 Mus’ab Banat1 1Department of Medicine and Family Medicine, Faculty of Medicine, Hashemite University, Zarqa, Jordan; 2Department of Public Health, Faculty of Medicine, Jordan ...
Shdaifat AA, Khader Y, Al Hyari M, Shatnawi O, Banat M   +4 more
doaj  

Predictive Accuracy of a Polygenic Risk Score Compared With a Clinical Risk Score for Incident Coronary Heart Disease.

Journal of the American Medical Association (JAMA), 2020
Importance Polygenic risk scores comprising millions of single-nucleotide polymorphisms (SNPs) could be useful for population-wide coronary heart disease (CHD) screening.
J. Mosley, D. Gupta, Jingyi Tan, Jie Yao, Q. Wells, C. Shaffer, S. Kundu, C. Robinson-Cohen, B. Psaty, S. Rich, W. Post, Xiuqing Guo, J. Rotter, D. Roden, R. Gerszten, Thomas J. Wang   +15 more
semanticscholar   +1 more source

Development and Validation of TACE Refractoriness-Related Diagnostic and Prognostic Scores and Characterization of Tumor Microenvironment Infiltration in Hepatocellular Carcinoma

Frontiers in Immunology, 2022
BackgroundTranscatheter arterial chemoembolization LIHC, Liver hepatocellular carcinoma; (TACE) is a valid therapeutic method for hepatocellular carcinoma (HCC). However, many patients respond poorly to TACE, thus leading to an adverse outcome. Therefore,
Qifan He, Jian Yang, Yonghai Jin
doaj   +1 more source