Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
The risk rate by ADR road transport of dangerous matters [PDF]
, 2009 The paper will be focused on the questions of ADR road transport of dangerous matters, especially on the risks estimation of transport of dangerous goods in the Czech Republic.
Brožová, Pavlína
core +1 more source
From climate change to cyber-attacks: incipient financial-stability risks for the euro area. Bruegel Policy Contribution Issue n˚2 | February 2020 [PDF]
, 2020 The European Central Bank’s November 2019 Financial Stability Review highlighted the risks to growth in an environment of global uncertainty. It also discusses sovereign-debt concerns in case interest rates increase, and risks arising from household and ...
Darvas, Zsolt +2 more
core
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Measuring Confidentiality Risks in Census Data [PDF]
, 1997 Two trends have been on a collision course over the recent past. The first is the increasing demand by researchers for greater detail and flexibility in outputs from the decennial Census of Population. The second is the need felt by the Census Offices to
Openshaw, S. +2 more
core
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
Introduction: Deterrence by Denial and the Long Journey of Addressing Biological Weapons Risks
Journal for Peace and Nuclear DisarmamentDeterrence by denial is a classic defense strategy in which the goal is to offset an adversary’s capabilities in ways that deny them success in achieving their intended military or strategic effects. If their modes of attack are unlikely to succeed – but
Christine Parthemore, Andy Weber
doaj +1 more source
The functional cytotoxic T lymphocyte–associated Protein 4 49G‐to‐A genetic variant and risk of pancreatic cancer [PDF]
, 2012 Ming Yang +12 more
openalex +1 more source