Results 191 to 200 of about 13,059,962 (346)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Biodiversity risks and corporate innovation: Evidence from China. [PDF]

PLoS One
Lin Y, Song Z.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Environmental Risks of Pesticide Residues in the Lake Tana Sub-basin, Ethiopia: A Review. [PDF]

Environ Manage
Admasu BG, Yao K, Yemer GG, Van den Brink PJ.   +3 more
europepmc   +1 more source

Climate change and interconnected risks to sustainable development in the Mediterranean

Nature Climate Change, 2018
W. Cramer, J. Guiot, Marianela Fader, J. Garrabou, Jean-Pierre Gattuso, A. Iglesias, M. Lange, P. Lionello, M. Llasat, S. Paz, J. Peñuelas, M. Snoussi, A. Toreti, M. Tsimplis, E. Xoplaki   +14 more
semanticscholar   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Risk? What Risk? [PDF]

The Annals of Occupational Hygiene, 1998
openaire   +2 more sources

Determinants of proactive health behaviors in individuals at high risks of stroke: a structural equation model analysis. [PDF]

Front Public Health
Wang M, Pan Y, Hou L, Su X, Yu B, Li N, Zhang L, Li X, Chen M, Zhang L.   +9 more
europepmc   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Hidden middle governance reduces antibiotic residue health risks and food loss in aquatic supply chains. [PDF]

iScience
Jin C, Wang Z, Zhou W, Fu S.
europepmc   +1 more source