Results 201 to 210 of about 14,156,764 (395)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Plasma carotenoids and risk of breast cancer over 20 y of follow-up [PDF]

, 2015
A. Heather Eliassen, Xiaomei Liao, Bernard Rosner, Rulla M. Tamimi, Shelley S. Tworoger, Susan E. Hankinson   +5 more
openalex   +1 more source

Self-Medication as an Important Risk Factor for Antibiotic Resistance: A Multi-Institutional Survey among Students [PDF]

, 2022
Shah Zeb, Mariam Mushtaq, Muneeb Ahmad, Waqas Saleem, Ali A. Rabaan, Bibi Salma Zahid Naqvi, Mohammed Garout, Mohammed Aljeldah, Basim R. Al Shammari, Nehad J. Al Faraj, Nisreen A. Al-Zaki, Mona J. Al Marshood, Thuria Y. Al Saffar, Khadija A. Alsultan, Shamsah H. Al-Ahmed, Jeehan H. Alestad, Muhammad Naveed, Naveed Ahmed   +17 more
openalex   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Metabolic abnormalities and obesity’s impact on the risk for developing preeclampsia [PDF]

, 2016
Frank T. Spradley
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Female sex, early-onset hypertension, and risk of dementia

, 2017
Paola Gilsanz, Elizabeth Rose Mayeda, M. Maria Glymour, Charles P. Quesenberry, Dan Mungas, Charles DeCarli, Alexander Dean, Rachel A. Whitmer   +7 more
openalex   +2 more sources

Tobacco Smoking Increases the Risk of High-Grade Dysplasia and Cancer Among Patients With Barrett's Esophagus [PDF]

, 2011
Helen G. Coleman, Shivaram Bhat, Brian T. Johnston, Damian McManus, Anna Gavin, Liam Murray   +5 more
openalex   +1 more source

Pubertal timing and breast cancer risk in the Sister Study cohort [PDF]

, 2020
Mandy Goldberg, Aimee A. D’Aloisio, Katie M. O’Brien, Shanshan Zhao, Dale P. Sandler   +4 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source