Results 1 to 10 of about 2,554,989 (200)

RITA plus 3-MA overcomes chemoresistance of head and neck cancer cells via dual inhibition of autophagy and antioxidant systems

Redox Biology, 2017
Reactivation of p53 and induction of tumor cell apoptosis (RITA) is a small molecule that blocks p53–MDM2 interaction, thereby reactivating p53 in tumors.
Daiha Shin, Eun Hye Kim, Jaewang Lee, Jong-Lyel Roh   +3 more
doaj   +2 more sources

Use of Software as a Medical Device to Improve Therapeutic Adherence in Patients With Hematological Malignancies: Prospective Interventional MargheRITA Study [PDF]

JMIR mHealth and uHealth
BackgroundHematological malignancies are a global health challenge, with a substantial number of deaths each year. Treatment adherence is crucial for improving patient outcomes in patients with hematological malignancies, but ...
Serena Camilla Dalto, Antonella Romanelli, Martina Violati, Carlotta Galeone, Davide Gaudesi, Francesca Sacchi, Massimo Beccaria, Mauro Moroni, Alessandro Ferri, Vittorio Montefusco   +9 more
doaj   +2 more sources

Therapeutic targeting of ARID1A-deficient cancer cells with RITA (Reactivating p53 and inducing tumor apoptosis)

Cell Death and Disease
ARID1A, a component of the SWI/SNF chromatin-remodeling complex, is frequently mutated in various cancer types and has emerged as a potential therapeutic target.
Zihuan Wang, Xu Zhang, Yuchen Luo, Yijiang Song, Cheng Xiang, Yilin He, Kejin Wang, Yingnan Yu, Zhen Wang, Wenxuan Peng, Yi Ding, Side Liu, Changjie Wu   +12 more
doaj   +2 more sources

Reactivating p53 and Inducing Tumor Apoptosis (RITA) Enhances the Response of RITA-Sensitive Colorectal Cancer Cells to Chemotherapeutic Agents 5-Fluorouracil and Oxaliplatin

Neoplasia: An International Journal for Oncology Research, 2017
Colorectal carcinoma (CRC) is the most common cancer of the gastrointestinal tract with frequently dysregulated intracellular signaling pathways, including p53 signaling.
Armin Wiegering, Niels Matthes, Bettina Mühling, Monika Koospal, Anne Quenzer, Stephanie Peter, Christoph-Thomas Germer, Michael Linnebacher, Christoph Otto   +8 more
doaj   +2 more sources

RITA modulates cell migration and invasion by affecting focal adhesion dynamics

Molecular Oncology, 2019
RITA, the RBP‐J interacting and tubulin‐associated protein, has been reported to be related to tumor development, but the underlying mechanisms are not understood.
Samira Catharina Hoock, Andreas Ritter, Kerstin Steinhäuser, Susanne Roth, Christian Behrends, Franz Oswald, Christine Solbach, Frank Louwen, Nina‐Naomi Kreis, Juping Yuan   +9 more
doaj   +2 more sources

Santa Rita, Rita, Rita. Saberes salvajes y memorias feministas.

Re-visiones
Al calor de la última ola de los feminismos se ha dado una emergencia de memorias feministas. Entre ellas, me interesa la recuperación de ciertas historias que encuentran en las maldiciones, las estampitas o las fantasmas la forma de expresión de sus ...
Lidia Mateo Leivas
doaj   +3 more sources

RITA Is Expressed in Trophoblastic Cells and Is Involved in Differentiation Processes of the Placenta

Cells, 2019
Preeclampsia (PE) remains a leading cause of maternal and perinatal mortality and morbidity worldwide. Its pathogenesis has not been fully elucidated and no causal therapy is currently available.
, Lukas Jennewein, Andreas Ritter
exaly   +3 more sources

Study on Therapeutic Action and Mechanism of TMZ Combined with RITA Against Glioblastoma

Cellular Physiology and Biochemistry, 2018
Background/Aims: Glioblastoma multiforme (GBM) is a malignant and aggressive central nervous system (CNS) tumor with high mortality and low survival rate. Effective treatment of GMB is a challenge worldwide. Temozolomide (TMZ) is a drug used to treat GBM,
Qinghua Wu, Zhongxu Cao, Weiwei Xiao, Li Zhu, Qian Xie, Ling Li, Bao  Zhang, Wei Zhao   +7 more
doaj   +2 more sources

Towards European harmonisation of healthcare for patients with rare immune disorders: outcome from the ERN RITA registries survey

Orphanet Journal of Rare Diseases, 2020
The Rare Immunodeficiency, AutoInflammatory and AutoImmune Disease (RITA) network is a European Research Network (ERN) that brings together the leading centres for rare immune disorders.
Riccardo Papa, Andrew Cant, Christoph Klein, Mark A. Little, Nico M. Wulffraat, Marco Gattorno, Nicolino Ruperto, on behalf of ERN RITA Council   +7 more
doaj   +2 more sources

RITA: a Study on Scaling Up Generative Protein Sequence Models [PDF]

arXiv.org, 2022
In this work we introduce RITA: a suite of autoregressive generative models for protein sequences, with up to 1.2 billion parameters, trained on over 280 million protein sequences belonging to the UniRef-100 database.
Daniel Hesslow, Niccoló Zanichelli, Pascal Notin, Iacopo Poli, D. Marks   +4 more
semanticscholar   +1 more source