Results 111 to 120 of about 31,287 (242)

Decoding IGLL5 Mutation‐Mediated BCR Signaling: A Novel Mechanism of CD8+ T Cell Exhaustion and Ocular MALT Lymphoma Progression

Advanced Science, EarlyView.
OAML harbors recurrent IGLL5 mutations that reinforce CD79A/CD79B‐associated BCR signaling. Mechanistic analysis of the S47G and A54G variants reveals induction of CXCL10/CXCL11, enhanced CD8+ T‐cell recruitment, and exhaustion‐associated dysfunction, supporting an immune‐tolerant niche.
Andi Zhao, Haoyu Wei, Chenyu Zhou, Xinping Sun, Shuyan Da, Haiyu Liu, Zijin Wang, Hui Zhu, Shiya Shen, Qing Shao, Qi Gong, Hu Liu, Xuejuan Chen   +12 more
wiley   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Rituximab for the treatment of patients with chronic lymphocytic leukemia

, 2010
M Gentile, E Vigna, C Mazzone, E Lucia, AG Recchia, L Morabito2, MG Bisconte, C Gentile, F Morabito1UOC di Ematologia, Azienda Ospedaliera di Cosenza, Italy; 2Servicio de Hematología y Hemoterapia, Hospital Universitario de Canarias, La Laguna,
C Mazzone, M Gentile, et al, E Vigna
core  

Anti-CD20 (rituximab) treatment improves atopic eczema

, 2008
BACKGROUND: Atopic eczema (AE) is a chronic inflammatory skin disorder characterized by eczematous skin lesions, pruritus, and typical histopathologic features.
Simon, Hans-Uwe, Nikhil Yawalkar, Kostylina, Ganna, Hans-Uwe Simon, Hösli, Susanne, Dagmar Simon, Susanne Hösli, Simon, Dagmar, Yawalkar, Nikhil, Ganna Kostylina   +9 more
core   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Intralesional rituximab injections for orbital granulomatosis with polyangiitis: a case series and literature review

Therapeutic Advances in Ophthalmology
Rituximab, an anti-CD-20 monoclonal antibody, has garnered increasing interest as a therapeutic option in orbital inflammatory disease (OID). We report our institutional experience with intralesional rituximab injections in two cases of orbital ...
Terence Ang, Jessica Y. Tong, Dinesh Selva   +2 more
doaj   +1 more source

Rituximab Administration in Third Trimester of Pregnancy Suppresses Neonatal B-Cell Development

Clinical and Developmental Immunology, 2008
We describe the effect on the neonate of administration of rituximab to a woman with idiopathic thrombocytopenic purpura (ITP). Rituximab, an anti-CD20 antibody, was given weekly for 4 weeks to a woman with ITP in her third trimester of pregnancy.
D. T. Klink, R. M. van Elburg, M. W. J. Schreurs, G. T. J. van Well   +3 more
doaj   +1 more source

Reconstitution of the lymphocyte population in patients with pemphigus subjected to ''ultra low'' doses of rituximab

reserved1. Background: Il rituximab, un anticorpo monoclonale anti-CD20, si è rivelato una terapia efficace nel trattamento del pemfigo volgare, una grave patologia caratterizzata dal punto di vista patogenetico dalla presenza di autoanticorpi, e dal ...
MICELLO, GIUSEPPE
core  

Exploring the Burden on Patients Living With and Receiving Treatment for Immune Thrombocytopenia (ITP): Patient and Physician Perceptions From the ITP World Impact Survey (I‐WISh) 2.0

American Journal of Hematology, EarlyView.
ABSTRACT Limited data exist on how patients and physicians perceive immune thrombocytopenia (ITP) symptoms and treatment‐related burden. I‐WISh (ITP World Impact Survey) 2.0 surveyed 1018 patients and 431 physicians in 15 countries to characterize the impact of ITP and its treatments on patients.
Nichola Cooper, James Bussel, Waleed Ghanima, Drew Provan, Yoshiaki Tomiyama, Ming Hou, Donald M. Arnold, Cristina Santoro, Francesco Zaja, Barbara Lovrencic, Mervyn Morgan, Michal Winograd, Jennifer DiRaimo, Danielle Boyle, Olivera Rajkovic‐Hooley, Meritxell Vendranas, Susan Frade, Caroline Kruse   +17 more
wiley   +1 more source

Rituximab en glomeruloesclerosis focal y segmentaria

, 2016
Introducción: El síndrome nefrótico es un trastorno renal multifactorial. Es la manifestación clínica de las alteraciones bioquímicas producidas por una lesión glomerular que altera la permeabilidad de la pared capilar glomerular.
Velasco Paredes, Margarita Maria, Urrego Lozano, Ntalia, Vacca Orrego, Luisa Maria, Pedraza García, Nedier, Salcedo Libreros, Luis Felipe   +4 more
core   +1 more source