Results 91 to 100 of about 3,483,721 (310)

From Lab to Landscape: Environmental Biohybrid Robotics for Ecological Futures

Advanced Robotics Research, EarlyView.
This Perspective explores environmental biohybrid robotics, integrating living tissues, microorganisms, and insects for operation in real‐world ecosystems. It traces the leap from laboratory experiments to forests, wetlands, and urban environments and discusses key challenges, development pathways, and opportunities for ecological monitoring and ...
Miriam Filippi
wiley   +1 more source

Diadromous Fish Investigations, 2016: Anadromous Alosid Restoration and Evaluation [PDF]

, 2017
Eight fishways on six New Hampshire (NH) coastal rivers were operated during the spring of 2016 to facilitate the passage of river herring (Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis), American Shad Alosa sapidissima, and other ...
NH Fish & Game
core   +1 more source

Spatiotemporal Sequential Delivery of Chidamide Regulates Macrophage Reprogramming in Lymphoma Microenvironment Through HDACs‐STAT3 Pathway

Advanced Science, EarlyView.
Our study identifies the HDACs‐STAT3 axis as key regulator for M2 macrophage accumulation in DLBCL. We developed Chid@M2pep‐EVs/TP, a pH‐responsive drug delivery system for M2 macrophage specific chidamide administration. By coupling M2‐targeted chidamide with EVs‐mediated delivery, this system reprograms M2 to M1 via HDAC inhibition and STAT3 ...
Bo Dai, Shuo Wang, Xiaotong Peng, Kunpeng Wu, Mengyao Wu, Zhaoning Lu, Haoshu Zhong, Xiaohan Qian, Shuiyi Tan, Hui Yang, Tanlezi Sun, Jing Wang, Jie Zhang, Hua Jiang, Yin Tong, Tong Chen   +15 more
wiley   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

Development of a hazard risk map for assessing pedestrian risk in urban flash floods: A case study in Cúcuta, Colombia

River
The rapid growth of impervious areas in urban basins worldwide has increased the number of impermeable surfaces in cities, leading to severe flooding and significant economic losses for civilians.
Gerald Augusto Corzo Perez, Diego Ivan Sanchez Tapiero, Manuel Antonio Contreras Martínez, Chris Zevenbergen   +3 more
doaj   +1 more source

River Tavy SAP Final Plan [PDF]

, 2000
This is the River Tavy Salmon Action Plan Final document produced by the Environment Agency in 2000. This final Salmon Action Plan (SAP) for the River Tavy catchment has been produced after consideration of feedback from external consultation.

core  

Marburg Virus Glycoprotein Is a Remarkable Virulent Factor Linked to Hemorrhagic Pathology: Evidence from Multimodal Experimental Systems

Advanced Science, EarlyView.
By integrating data from in vitro, ex vivo, and in vivo models, our research identifies the MARV glycoprotein as a remarkable hemorrhagic factor, filling a major gap in this important field. It also provides practical experimental tools for the basic research on viral pathogenesis and applied research aimed at antiviral intervention for hemorrhagic ...
Ting Yao, Hang Liu, Yanfeng Yao, Wei Deng, Jiawen Sun, Zhenyu Kang, Ashaq Ali, Chao Shan, Zhiming Yuan, Fei Deng, Hualin Wang, Yun‐Jia Ning   +11 more
wiley   +1 more source

A real‐time flood forecasting hybrid machine learning hydrological model for Krong H'nang hydropower reservoir

River
Flood forecasting is critical for mitigating flood damage and ensuring a safe operation of hydroelectric power plants and reservoirs. This paper presents a new hybrid hydrological model based on the combination of the Hydrologic Engineering Center ...
Phuoc Sinh Nguyen, Truong Huy (Felix) Nguyen, The Hung Nguyen   +2 more
doaj   +1 more source

Social technology and human health [PDF]

human development ...
David E. Bloom, River Path Associates and Karen Fang
core