Results 111 to 120 of about 936,141 (267)

White River Railway photograph album [PDF]

, 1903
This collection consists of a photograph album containing primarily photographs of the building of the White River Railway from Cotter, Ark., to near the Missouri State Line in Boone County ...
White River Railway (1901-1905)
core  

Study of meteorological‐hydrological drought propagation under reservoir regulation using a Copula‐Bayesian network in the Hanjiang River Basin

River
Reservoir operations play a pivotal role in modifying drought propagation processes, particularly by influencing the transition from meteorological to hydrological drought.
Yanping Qu, Cheng Li, Yachao Zhang, Siyu Zhao, Tianliang Jiang, Qinghua Ye   +5 more
doaj   +1 more source

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Geospatial technology based evaluation of recent morphodynamic changes and flow patterns in the upper Jhelum River

River
This study was conducted to address the concerns over the changes in river morphology and their implications for sustainable river management. It investigates the morphological dynamics of the Upper Jhelum River between 2018 and 2023, using high ...
Sumaira Javaid, Pervez Ahmed, Akhtar Alam, Mohd Wasit Manhas, Srija Roy   +4 more
doaj   +1 more source

NAD+ Metabolism Licenses Zygotic Genome Activation via PARP7‐Mediated ADP‐Ribosylation of UHRF1 in Mouse Early Embryos

Advanced Science, EarlyView.
This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Guangyi Cao, Ziqi Zhang, Anqi Chen, Yanbo Liu, Yuling Lin, Lina Yu, Ruixin Shi, Aolei Guo, Yan Mao, Ganggui Lou, Chaojun Li, Luhong Wen, Guijun Yan, Haixiang Sun   +13 more
wiley   +1 more source

Flood forecast and inundation mapping using a combined hydrologic and hydraulic model on Muga River Abay Basin, Ethiopia

River
This study presents an integrated flood forecasting and inundation mapping framework using coupled SWAT, HEC‐HMS, and HEC‐RAS models for the Muga River basin in the Abay Basin, Ethiopia.
Yikeber Ayenew Zeleke, Otoma Orkaido Garo, Yohannes Mehari Andiye   +2 more
doaj   +1 more source

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, EarlyView.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Global crisis in water management: Can a second UN Water Conference help?

River, 2023
Asit K. Biswas, Cecilia Tortajada
doaj   +1 more source

Assessment of the hydraulic performance of water supply distribution system in Gidole Town, Ethiopia

River
The majority of water utilities, particularly public service providers such as Gidole town, are struggling to deliver a sufficient and consistent supply of water in Ethiopia's developing towns.
Lemita Berisha Urto, Tewaso Harneso Shoke, Otoma Orkaido Garo   +2 more
doaj   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source