Results 131 to 140 of about 3,483,721 (310)

Myeloid‐Derived Grancalcin Promotes Periodontal Inflammation and Pathological Bone Remodeling in Periodontitis

Advanced Science, EarlyView.
Grancalcin (GCA), a myeloid‐derived protein, is enriched in gingival tissues of periodontitis patients and mouse models. Through interactions with CD44 and activation of MYH9, GCA promotes NF‐κB signaling and exacerbates periodontal inflammation and bone loss.
Min Zhou, Yao Xiao, Ziyue Xu, Chengyu Yang, Jiang Li, Ya Liu, Ping Yin   +6 more
wiley   +1 more source

The grain size distribution function of suspended load in the lower Yellow River

River
The log‐normal distribution function (LNDF) and Weibull cumulative density function (WCDF) represent two prevalent approaches for characterizing sediment grain size distributions.
Zipu Ma
doaj   +1 more source

Rivers and rivers [PDF]

Scottish Geographical Magazine, 1885
openaire   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Spatiotemporal variability of aerosol optical depth and climatic coupling over Jaipur city based on multi‐spectral satellite analysis

River
Aerosol dynamics in semi‐arid cities are key to understanding air quality and climate interactions. This study examines the spatiotemporal variability of Aerosol Optical Depth (AOD) over Jaipur, India, from 2018 to 2024 using MODIS observations at 470 ...
Aman Yadav, A. S. Jethoo, Kaushlandra Bairwa   +2 more
doaj   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Source analysis of nitrate pollution in a typical tributary of the upper Yellow River using a combined approach of stable isotopes and DOM fluorescence characteristics

River
Identifying the sources and characteristics of water pollution is essential for the protection and management of water environments. Nitrate (NO3−) is a key pollutant affecting water quality in the Qingshui River, a typical semi‐arid tributary in the ...
Bin Xu, Duo Zhang, Ziyang Wang, Jie Li, Zhiling Du, Longmian Wang, Qingqing Pang, Xiang Zhu, Lei Xie, Ran Tao, Huili Meng, Dongyan Pei, Fuquan Peng   +12 more
doaj   +1 more source

Ecological Adaptation Mechanisms Underlying Successful Plant Reproduction

Advanced Science, EarlyView.
During floral induction, various environmental and endogenous signals converge to regulate the florigen protein, which is transported from leaves to the SAM to initiate flowering. Within the SAM, a complex network of receptor kinases and small peptides orchestrates floral development with high spatiotemporal precision.
Hang Zhao, Shenghui Huo, Yue Xing, Shuxin Zhang, Guilin Li, Yihui Liu, Chongyang Jin, Fuguang Li, Xiaoyang Ge   +8 more
wiley   +1 more source

Seasonal dynamics and environmental drivers of dissolved organic matter distribution in heterogeneous river terrains

River
Dissolved organic matter (DOM) in rivers plays a key role in the global carbon cycle and aquatic ecosystems, yet its spatiotemporal dynamics across complex terrains remains inadequately characterized.
Kun Shi, Jiafeng Zhang, Yuting Zhao, Chenbin Wu, Xiao Luo, Shilei Zhou   +5 more
doaj   +1 more source

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source