Results 111 to 120 of about 1,671,595 (300)

Targeting Tex10 Overcomes Oxaliplatin Resistance by Competitively Disrupting the Non‐Canonical BAF Complex in Colorectal Cancer

Advanced Science, EarlyView.
This study reveals that Tex10 drives oxaliplatin resistance in colorectal cancer by competitively binding BRD9 to disrupt the ncBAF complex, thereby suppressing AMBRA1 transcription and ULK1‐mediated autophagy. Gemcitabine is identified as a direct Tex10 inhibitor that restores autophagy and overcomes resistance.
Ping Xu, Jie Huang, Xiaojin Gao, Lin Deng, Yanheng Deng, Denglu Wang, Chunlei Yu, Yunxiang Zhang, Jingdong Li, Xiaocong Xiang   +9 more
wiley   +1 more source

Research Progress of River Ecological Restoration

Shuitu baochi yanjiu, 2012
The ecological restoration of river ecosystem has become a research hotspot because the river ecosystems were generally severely damaged.On the basis of broad access to the information of the domestic and international ecological restoration,the ...
YANG Jun-peng1, WANG Tie-liang2, FAN Hao-ming2, SU Zi-long2   +3 more
doaj  

Interspecific Differences in Carbon and Nitrogen Metabolism and Leaf Epiphytic Bacteria among Three Submerged Macrophytes in Response to Elevated Ammonia Nitrogen Concentrations

Plants
Submerged macrophytes in eutrophic aquatic environments adapt to changes in ammonia nitrogen (NH4-N) levels by modifying their levels of free amino acids (FAAs) and soluble carbohydrates (SCs).
Heyun Wang, Kuang Chen, Hui Jin, Rui Hu
doaj   +1 more source

USP5 Stabilizes TGFBR1 to Drive Vascular Smooth Muscle Cell Senescence and Atherosclerosis

Advanced Science, EarlyView.
This study reveals that USP5 drives vascular smooth muscle cell senescence and atherosclerosis by stabilizing TGFBR1, suppressing IDH2, and promoting glycolytic reprogramming, identifying the USP5‐TGFBR1‐IDH2 axis as a potential therapeutic target. ABSTRACT Vascular smooth muscle cell (VSMC) senescence contributes importantly to atherosclerotic plaque ...
Xinhai Cui, Yuanlong Hu, Lin Lin, Lei Zhang, Chao Li, Yunlun Li   +5 more
wiley   +1 more source

Paradigm innovation and key technologies for ecohydrological regulation on the Loess Plateau

Shui kexue jinzhan
As an important region underpinning ecological security and water-resource balance in Northern China，the Loess Plateau’s ecohydrological regulation plays a pivotal and strategic role in ensuring water security across the Yellow River Basin.
Xizhi LYU, Hengshuo ZHANG, Tianling QIN, Denghua YAN   +3 more
doaj   +1 more source

The third dimension in river restoration: how anthropogenic disturbance changes boundary conditions for ecological mitigation. [PDF]

Sci Rep, 2020
Guzelj M, Hauer C, Egger G.
europepmc   +1 more source

AN EVALUATION OF RIVER RESTORATION EFFECTIVENESS IN A HOUSING LAND DEVELOPMENT AREA [PDF]

, 2013
River restoration is the act of working with a degraded river or stream in order to\ud return it to a pre-disturbed condition. Restoration of urban rivers is a new endeavor in\ud the world.
Tahir Lopa, Rita
core  

Synergistic p53 Pathway Activation Through Sono‐Gene Therapy Induced by Ultrasound‐Triggered Theranostic Mesoporous Nanoparticles

Advanced Science, EarlyView.
Schematic representation of ultrasound‐mediated ICG/siCD24@MSN‐LCD from nanostructure to synergistic sono‐gene therapy. This nanoplatform targets ASGPR via the LCD shell, which dissociates to release loaded ICG and siCD24. The core mechanism involves ultrasound‐guided sonodynamic therapy by ICG and CD24 knockdown by siCD24, both activating the p53 axis
Yading Zhao, Lu Guo, Dandan Shi, Xiao Sun, Mengmeng Shang, Song Ning, Shuting Huang, Xiaoxuan Wang, Rui Liu, Yuye Fu, Suyun Li, Jie Li   +11 more
wiley   +1 more source

#lovetordino: the Tordino River Contract geoblog

, 2014
Poster ammesso alla conferenza "European River Restoration Conference 2014" organizzata nelle date 27-29/10/2014 da European Center for River Restoration, SEE River c/o Vienna Il poster illustra le caratteristiche del Geoblog #lovetordino, organizzano ...
Di Berardo Mara
core  

Toward Personalized Theranostics: A Modular PET Platform for Antibody‐Based Imaging and Therapy

Advanced Science, EarlyView.
This modular, site‐specific antibody platform enables customizable conjugates for PET imaging and therapy. Interchangeable payloads – including radiometals, cytotoxics, and fluorophores – support adaptable, multimodal applications with limited off‐target effects. In vivo, the DFO/DOTAGA bischelate immunoconjugate provided clear tumor delineation in PET/
Delphine Vivier, Megane Grah Kple, Julen Ariztia, Marion Leroux, Mathieu Moreau, Michael Claron, Maxime Cheveau, Adam Laouafa, Agnieszka Kownacka, Camille Petitot, John Simonet, Alexandre M. M. Dias, Sophie Poty, Charles Truillet, Bertrand Collin, Alexandra Oudot, Franck Denat   +16 more
wiley   +1 more source