Results 31 to 40 of about 320,267 (265)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Underground mining impact on groundwater in Kuye River Basin, China: A coupling model study

River
The Kuye River Basin has experienced a rapid depletion of groundwater due to the increased coal production. In this study, by introducing the empirical equations derived from the three zone theory in the coal mining industry in China as a boundary ...
Shu Li, Yi Jing, Xiangyu Zhang, Fengran Zhang, Qingsong Qi, Ningbo Li, Le Bai   +6 more
doaj   +1 more source

Panama City Fisheries Resources Office: FY 2003 Annual Report [PDF]

, 2004
HIGHLIGHTS FOR FY 2003 1. Continued a 3-year threatened Gulf sturgeon population estimate in the Escambia River, Florida and conducted presence-absence surveys in 4 other Florida river systems and 1 bay. 2. Five juvenile Gulf sturgeon collected, near

core  

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Spatial–temporal evolution of economic-ecological benefits and their driving factors in Yellow River irrigation areas

Ecological Indicators
Understanding the spatial–temporal variations in the economic-ecological benefits and driving factors within the Yellow River irrigation areas (YRIA) is crucial for ensuring high-quality socioeconomic development and ecological environment health of the ...
Chang Liu, Enhui Jiang, Bo Qu, Lingqi Li, Lingang Hao, Wei Zhang   +5 more
doaj   +1 more source

Feeding the Future with the Past: Incorporating Local Ecological Knowledge in River Restoration

Resources, 2020
Despite many years of experience in the river restoration field, which has become one of the most promising areas of water resources management, significant challenges and problems remain.
Ewelina Szałkiewicz, Joanna Sucholas, Mateusz Grygoruk   +2 more
doaj   +1 more source

Diadromous Fish Investigations, 2016: Anadromous Alosid Restoration and Evaluation [PDF]

, 2017
Eight fishways on six New Hampshire (NH) coastal rivers were operated during the spring of 2016 to facilitate the passage of river herring (Alewife Alosa pseudoharengus and Blueback Herring Alosa aestivalis), American Shad Alosa sapidissima, and other ...
NH Fish & Game
core   +1 more source

Cost-benefit analysis of ecological networks assessed through spatial analysis of ecosystem services [PDF]

, 2012
1.The development of ecological networks could enhance the ability of species to disperse across fragmented landscapes and could mitigate against the negative impacts of climate change.
Balmford, Birch, Boitani, Brenman, Bullock, Cantarello, Crossman, Davies, de Groot, DECC, Egoh, Eycott, Fahrig, Fisher, Fuller, Jones-Walters, Jongman, Kareiva, Lawton, Naidoo, Naidoo, Nelson, Newell, Opdam, Rayment, Rouquette, Sutherland, TEEB, TEEB, The Wildlife Trusts, Treasury, Woodward   +31 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

The influence of in-stream structures on temperature dynamics via induced hyporheic exchange

Journal of Freshwater Ecology
In-stream restoration structures, such as woody weirs, are intended to enhance hyporheic exchange, thus altering temperature dynamics in restored reaches. However, the relative effects of various in-stream structure types and streambed settings (i.e. the
Jinghong Feng, Junxiong Luo, Ying Liu, Liu Defu, Linlin Li, Ziyan Lu, Xunchuan Song, Weiping Jiang   +7 more
doaj   +1 more source