Results 81 to 90 of about 320,267 (265)

Inhaled Angiopoietin‐Like 4 Antisense Oligonucleotide Therapy for Lung Injury and Fibrosis

Advanced Science, EarlyView.
Inhaled antisense oligonucleotides targeting ANGPTL4 attenuate inflammation, preserve barrier integrity, and reduce fibrosis in both infectious and sterile lung injury models. Integrated transcriptomic analysis reveals a conserved ANGPTL4‐regulated gene network coordinating hypoxic, inflammatory, apoptotic, and stress‐response pathways.
Haiyang Fan, Yuanyang Tan, Junhang Zhang, Xiaoya Liu, Jing Qu, Damien Chua, Hong Sheng Cheng, Joseph Han Sol Kim, Yu Xuan Liu, Changfei Qin, Yingzi Liu, Dezhi Li, Jikang Qiu, Mengshi Chi, Mingmin Bi, Qiwei Zhang, Yun Li, Masoumeh Motamedi Joibari, Stefan K Nilsson, Nguan Soon Tan, Yunping Fan, Liang Li   +21 more
wiley   +1 more source

Survival of Casuarina cunninghamiana on a recovering sand-bed stream in the Wollombi Valley of coastal New South Wales [PDF]

, 2013
The successful management and restoration of riparian corridors in Australia is currently hindered by our poor understanding of the links between hydrology, fluvial geomorphology and plant population dynamics.
Chalmers, Anita, Erskine, Fiona, Erskine, Wayne   +2 more
core   +1 more source

Pre‐Encoded IFN‐I Sensitivity Exacerbates Memory T Cell Senescence in Solid Tumors

Advanced Science, EarlyView.
Type I interferon (IFN‐I) signaling promotes p21‐dependent cell cycle arrest in senescent tumor‐specific memory T cells, resulting in poor proliferative responses and solid tumor regression during cancer vaccination. Conversely, IFNα/β receptor blockade reinvigorates T cell proliferation to regress solid tumors and is more effective with increasing ...
Andrew Nguyen, Scott R Walsh, Li Deng, Lan Chen, Yonghong Wan   +4 more
wiley   +1 more source

Public Preference Analysis and Social Benefits Evaluation of River Basin Ecological Restoration: Application of the Choice Experiments for the Shiyang River, China

Discrete Dynamics in Nature and Society, 2020
Revealing public preferences regarding the ecological restoration of a river basin and evaluating the associated social benefits provide important references for the development of related policies.
Tao Xu, Qi Ni, Liu-yang Yao, Dan Qiao, Min-juan Zhao   +4 more
doaj   +1 more source

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Attenuation of Influenza a Virus into Live Vaccines Through C‐End Degrons

Advanced Science, EarlyView.
Naturally occurring C‐end degrons are exploited to design proteolysis‐targeting live attenuated influenza vaccines. C‐end degron tagging of viral M1 protein promotes proteasome‐dependent degradation, resulting in robust attenuation in host cells while permitting scalable production in engineered cells.
Ping Wang, Le Li, Yunfang Chen, Le Tong, Zhen Li, Rong Yu, Quan Shen, Qikai Wang, Jihuan Hou, Qisi Zhang, Xu Si, Ning Wang, Demin Zhou, Wen‐xia Tian, Longlong Si   +14 more
wiley   +1 more source

Calcium‒phosphorus coprecipitation induced by Hydrilla verticillata photosynthesis: response to elevated phosphorus concentration and regulation by light intensity, inorganic carbon and calcium levels

Journal of Freshwater Ecology
To evaluate whether photosynthesis-induced calcium‒phosphorus (Ca‒P) coprecipitation in Hydrilla verticillata can be harnessed for eutrophic freshwater phytoremediation, we conducted controlled light incubator experiments to determine how key ...
Ziying Li, Heyun Wang, Yi Zhou, Min Wang
doaj   +1 more source

Rice Center focuses on restoring wetlands [PDF]

, 2016
Halfway between Richmond and Williamsburg, where Kimages Creek flows into the James River, lies the Inger and Walter Rice Center for Environmental Life Sciences. A restoration project aims to return the area to its original state as a wetland.
Rubis, Chris
core   +1 more source

Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders

Advanced Science, EarlyView.
In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang, Nan Liang, Wenbo Li, Shuai Xu, Peng Li, Wanze Ni, Na Li, Sha Han, Ningjing Ou, Haowei Bai, Yuxiang Zhang, Furong Bai, Yifan Sun, Dewei Qian, Xinjie Bu, Erlei Zhi, Ruhui Tian, Yuhua Huang, Jingpeng Zhao, Fujun Zhao, Hao Chen, Zheng Li, Chencheng Yao   +22 more
wiley   +1 more source

The Mechanical Properties of Reinforced Concrete Columns with Longitudinal Pre-Embedded Holes

Applied Sciences
While the longitudinal pre-embedded holes in a reinforced concrete column have a variety of beneficial functions during the whole life of the building, they have certain negative influences on the mechanical properties of the column.
Junzheng Zhang, Weisheng Xu, Jianjun Ye, Xuexi Liu   +3 more
doaj   +1 more source