Results 151 to 160 of about 622,843 (190)

Prognostic Implication of CYP2C19 Genotype According to Clinical Risk Stratification After Drug-Eluting Stent Implantation. [PDF]

Clin Pharmacol Ther
Park HW, Lee JH, Jeong JO, Gorog DA, Tantry US, Kim BK, Joo HJ, Chang K, Hwang JY, Song YB, Ahn SG, Suh JW, Choi WG, Cho JR, Kang J, Lee SY, Kim HS, Kim MH, Lim DS, Shin ES, Gurbel PA, Jeong YH, PTRG‐DES Consortium Investigators.   +22 more
europepmc   +1 more source

Chronic Kidney Disease‐Associated Pruritus Is Linked to Selective Enrichment of Taurine‐Conjugated Bile Acid Subspecies

JEADV Clinical Practice, EarlyView.
Chronic kidney disease‐associated pruritus (CKDaP) is a frequent complication of advanced CKD with an incompletely understood pathophysiology. We identified a significantly altered glycine‐to‐taurine conjugated bile acid ratio in patients with CKDaP despite unchanged total serum bile acid concentrations.
Miriam M. Düll, Manfred Rauh, Peter Dietrich, Marcel Vetter, Jonas Schmid, Thomas Mettang, Andreas E. Kremer   +6 more
wiley   +1 more source

Identification of a large <i>DPYD</i> gene deletion undetected by standard genotyping in a patient with severe capecitabine-related toxicity: a case report. [PDF]

Front Pharmacol
Delcuratolo MD, Rodriquenz MG, Morelli F, Latiano TP, Muscarella LA, Caporilli S, Pasqualini L, De Santis E, Giambra V, Rinaldi A, Ciavarella G, Floris M, Murru R, Mascia A, De Mattia E, Canil G, Fania G, Pop A, Carella M, van Kuilenburg A, Cecchin E, Miscio G.   +21 more
europepmc   +1 more source

Therapeutic JAK Inhibition in Idiopathic Subglottic Stenosis

The Laryngoscope, EarlyView.
Three patients with idiopathic subglottic stenosis and rheumatoid arthritis began JAK inhibitor therapy, after which the mean surgical‐free interval between endoscopic dilations rose from 317 to 631 days and the annualized dilation rate fell from 1.24 to 0.38 per patient‐year. Figure 2 shows this as a per‐patient timeline.
Riley M. Larkin, Ioan Lina, Julianna Kostas, Caroline Christmann, Kevin Byram, Alexander Gelbard   +5 more
wiley   +1 more source

Paediatric developmental safety and the ICH E11A extrapolation of safety. [PDF]

Br J Clin Pharmacol
Burckart GJ, Abdel-Rahman SM, Abulwerdi G, Racz R, Samuels S, Green DJ, Yao LP.   +6 more
europepmc   +1 more source

Progressive Supranuclear Palsy in India: Insights from a Large Multicenter Clinical Cohort (Project PAIR‐PSP)

Movement Disorders Clinical Practice, EarlyView.
Background Progressive supranuclear palsy (PSP) is a rare and devastating tauopathy with limited global data. Given India's large population, genetic diversity, and clinical heterogeneity, large multicenter datasets are crucial to enrich global understanding of PSP. Objective To characterize the demographic, clinical, and phenotypic profiles of a large
Prashanth Lingappa Kukkle, Divyani Garg, Jacky Ganguly, Soaham Desai, Rukmini Mridula Kandadai, Sahil Mehta, Pettarusp Murzban Wadia, Deepika Joshi, Lulup Sahoo, Vijayashankar Paramanandam, Taallapalli Ashok Vardhan Reddy, Adreesh Mukherjee, Syam Krishnan, Kuldeep Shetty, Charulata Sankhla, Pankaj Agarwal, Heli S. Shah, Suvorit Bhowmick, Mitesh Chandarana, Malini Venkata, Thenral S. Geetha, Ramesh Menon, Sandeep Charugulla, Sakthivel Murugan, Ravi Gupta, Niraj Kumar, Atanu Biswas, Hrishikesh Kumar, Rupam Borgohain, Huw Morris, Vedam. L Ramprasad, Parkinson's Research Alliance of India (PRAI) and the Global Parkinson's Genetic Program (GP2)   +31 more
wiley   +1 more source

Rationale of renewed efforts in developing MC4R modulators to treat metabolic disorders. [PDF]

Acta Pharm Sin B
Feng W, Zhou Q, Wang MW.
europepmc   +1 more source

Driving Cerebellar Theta Oscillations Interferes With Voluntary Neck Movements in Cervical Dystonia

Movement Disorders, EarlyView.
Abstract Background Cervical dystonia (CD) is a movement disorder with a complex pathophysiology, including cerebellar abnormalities. Transcranial alternating current stimulation (tACS), a noninvasive neuromodulation technique capable of entraining brain oscillations, can transiently modulate neuronal activity and enhance resonant rhythms.
Davide Costa, Andrea Guerra, Daniele Birreci, Massimiliano Passaretti, Martina De Riggi, Anna Sofia Grandolfo, Valentina D'Onofrio, Luca Angelini, Giulia Paparella, Matteo Bologna   +9 more
wiley   +1 more source

Effect of Individual and Combined Cytochrome P450 Activity Scores on Symptom Improvement and Side Effects in Youth Treated With Sertraline. [PDF]

Clin Transl Sci
Gerlach S, Maruf AA, Shaheen SM, McCloud R, Heintz M, McAusland L, Arnold PD, Bousman CA.   +7 more
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source