Results 161 to 170 of about 622,843 (190)

Advancing Therapies for Mycobacterial Diseases: From Small Molecules to Host‐Directed Strategies

Medicinal Research Reviews, EarlyView.
ABSTRACT The global burden of multidrug‐resistant tuberculosis (MDR‐TB) and the rising incidence of nontuberculous mycobacterial (NTM) infections highlight the urgent need for innovative therapeutic strategies. Current treatments are prolonged, toxic, and increasingly compromised by resistance and limited diagnostic capacity.
Tânia Silva, Alessandra Aiello, Tonino Alonzi, M. Alice Carvalho, Vladimir Finger, Delia Goletti, Sven Hoffner, Yousra Kherabi, Jan Korabecny, Julia Kulczyńska, Agnieszka Kyzioł, Alicia Lacoma, Filomena Martins, Zorica Nanovic, Sepideh Hosseiniporgham, Martina Hrast Rambaher, Leonardo Antonio Sechi, Daria Smalchuk, Grażyna Stochel, Lydia Tabernero, Nancy L. Tateosian, Violeta Valcheva, Anamarija Zega, Mafalda Sarraguça   +23 more
wiley   +1 more source

Clinical Pharmacogenetics Implementation Consortium Guideline for NAT2 Genotype and Hydralazine Therapy. [PDF]

Clin Pharmacol Ther
Eadon MT, Hein DW, Andersen MA, Chapman AB, Cooper-DeHoff RM, Desta Z, Duarte JD, Elchynski AL, Gaedigk A, Karol SE, Limdi NA, Lteif C, Sosinski L, Zubiaur P, Whirl-Carrillo M, Klein TE, Caudle KE, Donnelly RS, Agúndez JAG.   +18 more
europepmc   +1 more source

Correlating Pulmonary Hemodynamics With HP 129Xe Dissolved‐Phase MRSI in a Controlled Porcine Intervention Study

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose Pulmonary hypertension is related to a 1‐year mortality ranging from < 5% to > 20% in low‐ and high‐risk groups. Right heart catheterization is the diagnostic gold standard, associated with a 1.1% rate of severe adverse events, posing the need for a non‐invasive diagnostic tool.
Markus Phillip Andersen, Mattias Hedegaard Kristensen, Esben Søvsø Szocska Hansen, Rolf F. Schulte, Mohsen Redda, Uffe Kjærgaard, Michael Vaeggemose, Christoffer Laustsen   +7 more
wiley   +1 more source

CYP2C19 Polymorphism and Platelet Aggregation-Associated Risks in Atrial Fibrillation Patients Undergoing PCI. [PDF]

Clin Transl Sci
Gjermeni D, Szabó S, Anfang V, Vetter H, Juelch C, Rademacher S, Li T, Leggewie S, Hesselbarth D, Duerschmied D, Trenk D, Westermann D, Olivier CB.   +12 more
europepmc   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, EarlyView.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Low-intervention clinical trials in Spain: Do they progress? [PDF]

Br J Clin Pharmacol
Delgado-Espinoza CE, Cortés Pestana MJ, Amaro K, Antonijoan RM, Pontes C.   +4 more
europepmc   +1 more source

Diagnosis of Portal Hypertension: Advancing Towards Non‐Invasive Solutions

Portal Hypertension &Cirrhosis, EarlyView.
This review systematically summarizes a full spectrum of non‐invasive diagnostic approaches for portal hypertension (PH), including imaging modalities, elastography, serum biomarkers, composite scoring systems and endoscopic ultrasound‐guided portal pressure gradient (EUS‐PPG), and analyzes their performance across different liver disease etiologies ...
Lijia Yin, Huikuan Chu, Ling Yang
wiley   +1 more source

LPA/LPAR signaling drives temporomandibular disorders-like pain through regulating the expression and sensitization of PIEZO2. [PDF]

Sci Adv
Zhang Q, Su S, Liang P, Chen Y, Kim M, Baldi R, Wang P, Dias FC, Jang M, Gonzalez Torres MA, Lim P, Moreira RWF, Chun J, Guilak F, Yang H, Liedtke W, Nackley A, Chen Y.   +17 more
europepmc   +1 more source

Biocontrol and plant growth‐promoting potential of Streptomyces strains against fungal pathogens of tomato and wheat for a sustainable agriculture

Pest Management Science, EarlyView.
This study highlights the biocontrol potential of Streptomyces strain Strep_22. In vitro, it inhibits key fungal pathogens by 91.52%. In vivo, it significantly reduces disease incidence in wheat and tomato while enhancing biomass, shoot, and root development, offering a highly promising, sustainable ecological alternative to chemical pesticides ...
Thomas Conte, Maria Grazia Morea, Gaetana Ricciardi, Angelo Pastino, Francesco Lops, Maria Luisa Raimondo, Antonia Carlucci   +6 more
wiley   +1 more source

Correlation Between Renal Biomarkers, Glomerular Filtration Rate, and Meropenem Clearance in Pediatric Septic Shock. [PDF]

J Pediatr Pharmacol Ther
Vo B, Huynh J, Mak RH, Momper JD, Avedissian SN, Capparelli EV, Harvey H, Bradley E, Ramchandar N, Kim SJ, Yang EM, Bradley JS, Le J.   +12 more
europepmc   +1 more source