Results 31 to 40 of about 7,103,681 (193)

First observation of edge impurity behavior with n = 1 RMP application in EAST L-mode plasma

Nuclear Fusion
High-Z impurity accumulation suppression and mitigation in core plasma is frequently observed in EAST edge localized mode mitigation experiments by using resonant magnetic perturbations (RMP) coils.
Wenmin Zhang, Ling Zhang, Yunxin Cheng, Shigeru Morita, Hui Sheng, Darío Mitnik, Youwen Sun, Zhengxiong Wang, Yuqi Chu, Ailan Hu, Yinxian Jie, Haiqing Liu   +11 more
doaj   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Suppression of sawtooth oscillations by m/n = 2/2 resonant magnetic perturbation

Nuclear Fusion
Significant extension of sawtooth control toward higher electron density ( n _e ) and edge safety factor ( q _a ) ranges has been achieved by m / n = 2/2 resonant magnetic perturbation (RMP), which is ∼8 times stronger than the previous RMP generated by ...
Jianchao Li, Yu Zhang, Xiaoqing Zhang, Nengchao Wang, Yangbo Li, Zhengkang Ren, Chuanxu Zhao, Zhipeng Chen, Zhoujun Yang, Song Zhou, Wei Yan, Donghui Xia, Yonghua Ding, Chen Zhongyong, the J-TEXT Team   +14 more
doaj   +1 more source

Effective control of intrinsic impurities using n = 1 resonant magnetic perturbation (RMP) in EAST H-mode plasma

Nuclear Materials and Energy
Since 2021, EAST tokamak has been operated with full tungsten divertors. Tungsten accumulation has been frequently observed in NBI-heated H-mode discharges, resulting in the degradation of plasma confinement performance.
Wenmin Zhang, Ling Zhang, Shigeru Morita, Yunxin Cheng, Hui Sheng, Chengxi Zhou, Huihui Wang, Youwen Sun, Yuqi Chu, Ning Sun, Ailan Hu, Darío Mitnik, Yinxian Jie, Haiqing Liu   +13 more
doaj   +1 more source

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

Advanced Science, EarlyView.
CB1R and ASIC3 are co‐expressed in CGRP+ nociceptors of mouse DRG. Plantar incision triggers an upregulation of ASIC3 and activation of ASIC3+ neurons, driving mechanical allodynia. CB1R activation suppresses ASIC3 function and downstream ERK1/2 phosphorylation, thereby braking nociceptive signaling and accelerating pain resolution.
Kangtai Xu, Luyao Ji, Haoyi Yang, Xiying Chen, Qiaodan Hu, Haimei He, Jiawei Wu, Leyan Shan, Shihui Feng, Yingzhi Li, Xiongchang Tan, Hao Wang, Zilong Wang, Chaoran Wu   +13 more
wiley   +1 more source

Research Mentorship Program (RMP) to Enhance the Research Productivity in a Psychiatric Hospital: First Report [PDF]

Electronic Physician, 2011
Background: Despite rapid movement in student research in recent years, there is still little evidence that shows the impact of students' activities on research productivity.
Zhila Afshar, Younes Ebrahimzadeh, Seyed Hamzeh Seddigh, Javad Golmirzaei, Hamidreza Mahboobi, Mohammad Esmaeil Shahrzad, Tahereh Khorgoei   +6 more
doaj  

Decoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe

British Journal of Clinical Pharmacology, EarlyView.
Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...
Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin   +4 more
wiley   +1 more source

Tailoring resonant magnetic perturbation to optimize fast-ion confinement during ELM control in KSTAR

Nuclear Fusion, 2023
3D resonant magnetic perturbation (RMP) is one promising way to control edge localized modes that can cause excessive material erosion of tokamak first walls.
S.M. Yang, J.-K. Park, H.S. Kim, M. Podesta, J.S. Kang, T. Rhee   +5 more
doaj   +1 more source

Effects of RMP-induced changes of radial electric fields on microturbulence in DIII-D pedestal top

Nuclear Fusion, 2019
Gyrokinetic simulations of DIII-D tokamak with axisymmetric equilibrium show that the reduction in the radial electric field shear at the top of the pedestal during edge localized mode (ELM) suppression with the n = 2 resonant magnetic perturbations (RMPs) leads to enhanced drift-wave turbulence and extended turbulence spreading to the top of the ...
S. Taimourzadeh, L. Shi, Z. Lin, R. Nazikian, I. Holod, D. Spong   +5 more
openaire   +2 more sources

Cell and Gene Therapies Manufacturing Challenges and Integrated Good Manufacturing Practices Solutions: A Lifecycle Perspective

Biotechnology and Bioengineering, EarlyView.
Lifecycle perspective on cell and gene therapy manufacturing challenges and enabling GMP solutions. ABSTRACT Cell and gene therapies (CGTs) are revolutionizing modern medicine; however, making these advanced medicines scalable and readily available to commercial manufacturers worldwide is a major challenge. The number of approved CGT products continues
Rajath Samaga, Udisha Singh, Sachin Dattram Pawar   +2 more
wiley   +1 more source