Results 101 to 110 of about 819,809 (314)

Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics [PDF]

, 2018
The proteobacteria Variovorax sp. WDL1, Comamonas testosteroni WDL7, and Hyphomicrobium sulfonivorans WDL6 compose a triple-species consortium that synergistically degrades and grows on the phenylurea herbicide linuron.
Anders, Aziz, Beliaev, Bers, Bleichrodt, Boon, Breugelmans, Breugelmans, Cerqueda-Garcia, Colwell, Dealtry, Dejonghe, Dwyer, Foster, Frias-Lopez, Garbeva, Garcia, Gonzalez-Torres, Hansen, Horemans, Horemans, Horemans, Horemans, Horinouchi, Ilut, Kanehisa, Kell, Kimes, Krol, Love, MacLean, Maeyer, Nadell, Palama, Perez, Reasoner, Rickard, Rosenthal, Russell, Sabag-Daigle, Sambrook, Shimoyama, Subramoni, Suzuki, Tai, Teramoto, Ward, Wenter, West, Wu, Zerbino, Zgur-Bertok, Zhou   +52 more
core   +2 more sources

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Agnodice: indexing experimentally supported bacterial sRNA-RNA interactions

mBio
In the last decade, the immense growth in the field of bacterial small RNAs (sRNAs), along with the biotechnological breakthroughs in Deep Sequencing permitted the deeper understanding of sRNA-RNA interactions.
Vasiliki Kotsira, Giorgos Skoufos, Athanasios Alexiou, Maria Zioga, Spyros Tastsoglou, Filippos S. Kardaras, Nikos Perdikopanis, Zacharopoulou Elissavet, Vasileios Gouzouasis, Theodosia Charitou, Artemis G. Hatzigeorgiou   +10 more
doaj   +1 more source

Detecting RNA-RNA interactions in E. coli using a modified CLASH method

BMC Genomics, 2017
Background Bacterial small regulatory RNAs (sRNAs) play important roles in sensing environment changes through sRNA-target mRNA interactions. However, the current strategy for detecting sRNA-mRNA interactions usually combines bioinformatics prediction ...
Tao Liu, Kaiyu Zhang, Song Xu, Zheng Wang, Hanjiang Fu, Baolei Tian, Xiaofei Zheng, Wuju Li   +7 more
doaj   +1 more source

Computational search for UV radiation resistance strategies in Deinococcus swuensis isolated from Paramo ecosystems [PDF]

, 2019
Ultraviolet radiation (UVR) is widely known as deleterious for many organisms since it can cause damage to biomolecules either directly or indirectly via the formation of reactive oxygen species. The goal of this study was to analyze the capacity of high-
Acosta, Iván Camilo, Díaz-Riaño, Jorge, García-Castillo, Catalina, Posada, Leonardo, Reyes, Alejandro, Ruíz-Pérez, Carlos, Zambrano, María Mercedes   +6 more
core   +2 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Bacterial RNA sensing by TLR8 requires RNase 6 processing and is inhibited by RNA 2’O-methylation

EMBO Reports
TLR8 senses single-stranded RNA (ssRNA) fragments, processed via cleavage by ribonuclease (RNase) T2 and RNase A family members. Processing by these RNases releases uridines and purine-terminated residues resulting in TLR8 activation. Monocytes show high
Ivanéia V Nunes, Luisa Breitenbach, Sarah Pawusch, Tatjana Eigenbrod, Swetha Ananth, Paulina Schad, Oliver T Fackler, Falk Butter, Alexander H Dalpke, Lan-Sun Chen   +9 more
doaj   +1 more source

Microbial residence time is a controlling parameter of the taxonomic composition and functional profile of microbial communities. [PDF]

, 2019
A remaining challenge within microbial ecology is to understand the determinants of richness and diversity observed in environmental microbial communities.
Achermann, Stefan, Fenner, Kathrin, Johnson, David R, Joss, Adriano, Mansfeldt, Cresten, Men, Yujie, Villez, Kris, Walser, Jean-Claude   +7 more
core   +3 more sources

Liquid Crystalline Inverted Lipid Phases and Reverse Micelles in Drug Delivery: From Molecular Design to Therapeutic Potential

Advanced Functional Materials, EarlyView.
Liquid crystalline inverted lipid phases and reverse micelles are self‐assembled lipid nanostructures that enhance the solubility, stability, and delivery of diverse therapeutics. This review integrates their physicochemical principles, formulation strategies, drug loading mechanisms, and biomedical applications, highlighting their growing ...
Numan Eczacioglu, Mulazim Hussain Asim, Soheil Haddadzadegan, Andreas Bernkop‐Schnürch   +3 more
wiley   +1 more source

Illuminating Messengers: An Update and Outlook on RNA Visualization in Bacteria

Frontiers in Microbiology, 2017
To be able to visualize the abundance and spatiotemporal features of RNAs in bacterial cells would permit obtaining a pivotal understanding of many mechanisms underlying bacterial cell biology.
Lieke A. van Gijtenbeek, Jan Kok
doaj   +1 more source