Results 81 to 90 of about 2,082,862 (311)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

APEX2 proximity labeling of RNA in bacteria

Cell Reports: Methods
Summary: Rapid, spatially controlled methods are needed to investigate RNA localization in bacterial cells. APEX2 proximity labeling was shown to be adaptable to rapid RNA labeling in eukaryotic cells and, through the fusion of APEX2 to different ...
Hadi Yassine, Elizabeta Sirotkin, Omer Goldberger, Vincent A. Lawal, Daniel B. Kearns, Orna Amster-Choder, Jared M. Schrader   +6 more
doaj   +1 more source

An optimised method for the extraction of bacterial mRNA from plant roots infected with Escherichia coli O157:H7

Frontiers in Microbiology, 2014
Analysis of microbial gene expression during host colonisation provides valuable information on the nature of interaction, beneficial or pathogenic, and the adaptive processes involved.
Ashleigh eHolmes, Louise eBirse, Robert Wilson Jackson, Nicola eHolden   +3 more
doaj   +1 more source

Identification of an ortholog of the eukaryotic RNA polymerase III subunit RPC34 in Crenarchaeota and Thaumarchaeota suggests specialization of RNA polymerases for coding and non-coding RNAs in Archaea. [PDF]

, 2009
Contains fulltext : 80405.pdf (Publisher’s version ) (Open Access)One of the hallmarks of eukaryotic information processing is the co-existence of 3 distinct, multi-subunit RNA polymerase complexes that are dedicated to the ...
Makarova, K.S., Siebers Bettina, Koonin Eugene V, Bettina Siebers, Siebers, B.G., Kira S Makarova, Blombach Fabian, Fabian Blombach, Makarova Kira S, John Oost, Koonin, E.V., Oost, J., van der, Siebers, B., Marrero, J., Oost John, van der Oost, J., Blombach, F., Oost, J. van der, Marrero Jeannette, Jeannette Marrero, Eugene V Koonin   +20 more
core   +2 more sources

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Single-Cell RNA Sequencing of Plant-Associated Bacterial Communities

Frontiers in Microbiology, 2019
Plants in soil are not solitary, hence continually interact with and obtain benefits from a community of microbes (“microbiome”). The meta-functional output from the microbiome results from complex interactions among the different community members with ...
Qin Ma, Heike Bücking, Jose L. Gonzalez Hernandez, Jose L. Gonzalez Hernandez, Senthil Subramanian, Senthil Subramanian   +5 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Purification of Bacterial RNA from Infected Macrophages

Bio-Protocol, 2015
Studying the transcriptome of bacterial pathogens during infection is a very informative and effective tool for discovering genes that contribute to successful infection.
Lior Lobel, Nadejda Sigal, Anna Pasechnek, Anat Herskovits   +3 more
doaj   +1 more source

Global snapshots of bacterial RNA networks [PDF]

The EMBO Journal, 2016
While bacteria were long thought to rely primarily on transcriptional control, it is now well established that they also use numerous small RNAs to regulate mRNA translation and stability. There has recently been a surge in studies, including one by Waters et al ([2017][1]) in this issue of The EMBO Journal , that have used clever variations of the RNA‐
Hör, Jens, Vogel, Jörg
openaire   +3 more sources

L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy [PDF]

, 2006
Ribosomal proteins are assumed to stabilize specific RNA structures and promote compact folding of the large rRNA. The conformational dynamics of the protein between the bound and unbound state play an important role in the binding process.
Wöhnert, Jens, Hendrik R. A. Jonker, Harald Schwalbe, Ilin, Serge, S. Kaspar Grimm, Grimm, Steffen Kaspar, Jens Wöhnert, Jonker, Hendrik R. A., Schwalbe, Harald (Prof. Dr.), Serge Ilin   +9 more
core   +2 more sources