Results 81 to 90 of about 532,169 (312)

Small RNAs in Bacterial Virulence and Communication

Microbiology Spectrum, 2016
ABSTRACT Bacterial pathogens must endure or adapt to different environments and stresses during transmission and infection. Posttranscriptional gene expression control by regulatory RNAs, such as small RNAs and riboswitches, is now considered central to adaptation in many bacteria, including pathogens.
Sarah L, Svensson, Cynthia M, Sharma
openaire   +2 more sources

Combined 5‐aminolevulinic acid and ferric ammonium citrate treatment promotes hair follicle growth by activating dermal papilla cells

FEBS Open Bio, EarlyView.
5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley   +1 more source

New RNA-seq approaches for the study of bacterial pathogens.

, 2017
Understanding how bacteria cause disease requires knowledge of which genes are expressed and how they are regulated during infection. While RNA-seq is now a routine method for gene expression analysis in bacterial pathogens, the past years have also ...
Vogel, Jörg, Saliba, Antoine-Emmanuel, Jörg Vogel, C Santos, Sara, Antoine-Emmanuel Saliba, Sara C Santos   +5 more
core   +1 more source

Synthesis of empty bacterial microcompartments, directed organelle protein incorporation, and evidence of filament-associated organelle movement [PDF]

, 2010
Compartmentalization is an important process, since it allows the segregation of metabolic activities and, in the era of synthetic biology, represents an important tool by which defined microenvironments can be created for specific metabolic functions ...
Prentice, M.B., Mulvihill, D.P., Frank, S., Bhella, D., Frank, Stefanie, Parsons, J.B., Bhella, David, Prentice, Michael B., Liang, M., Mulvihill, Daniel P., Warren, Martin J., Parsons, Joshua B., Warren, M.J., Liang, Mingzhi   +13 more
core   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A comparison of rpoB and 16S rRNA as markers in pyrosequencing studies of bacterial diversity [PDF]

, 2012
Background: The 16S rRNA gene is the gold standard in molecular surveys of bacterial and archaeal diversity, but it has the disadvantages that it is often multiple-copy, has little resolution below the species level and cannot be readily interpreted in ...
Kowalchuk, GA, Quince, Christopher, Christopher Quince, de Hollander, M, Quince Christopher, Vos, M., Pijl, Agata S., Vos Michiel, Michiel Vos, Vos, M, Pijl, A.S., Agata S. Pijl (183429), Quince, C., Pijl Agata S., Kowalchuk, G.A., Mattias de Hollander, Hollander, M. de, Michiel Vos (63922), Mattias de Hollander (183437), Vos, Michiel, Quince, C, George A Kowalchuk, Kowalchuk George A., Pijl, AS, de Hollander, Mattias, George A. Kowalchuk (183442), Agata S Pijl, Kowalchuk, George A., Christopher Quince (178494), de Hollander, M., de Hollander Mattias   +30 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

An improved bacterial mRNA enrichment strategy in dual RNA sequencing to unveil the dynamics of plant-bacterial interactions

Plant Methods
Background Dual RNA sequencing is a powerful tool that enables a comprehensive understanding of the molecular dynamics underlying plant-microbe interactions.
Jayabalan Shilpha, Junesung Lee, Ji-Su Kwon, Hyun-Ah Lee, Jae-Young Nam, Hakgi Jang, Won-Hee Kang   +6 more
doaj   +1 more source

RNA-Binding Proteins Driving the Regulatory Activity of Small Non-coding RNAs in Bacteria

Frontiers in Molecular Biosciences, 2020
Small non-coding RNAs (sRNAs) are critical post-transcriptional regulators of gene expression. Distinct RNA-binding proteins (RBPs) influence the processing, stability and activity of bacterial small RNAs.
Ana P. Quendera, André F. Seixas, Ricardo F. dos Santos, Inês Santos, João P. N. Silva, Cecília M. Arraiano, José M. Andrade   +6 more
doaj   +1 more source

Analyses of the archaeal transcription cycle reveal a mosaic of eukaryotic RNA polymerase II and III-like features

, 2009
Novel mechanistic properties of the archaeal transcription system that reveal similarities especially to the eukaryotic RNA polymerase II and III systems were presented in thesis.
Spitalny, Patrizia
core   +1 more source