Results 131 to 140 of about 2,869,940 (329)

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration

Advanced Functional Materials, EarlyView.
Eco‐friendly nanowave‐textured implants produced via femtosecond laser fabrication enhance bone regeneration by orchestrating a precise mechanotransduction cascade. This nanotopography directs mesenchymal stem cell alignment and cytoskeletal organization, triggering changes in nuclear shape and chromatin acetylation that prime cells for osteogenesis ...
Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee   +15 more
wiley   +1 more source

Metatranscriptomic profiling reveals pathogen and host response signatures of pediatric acute sinusitis and upper respiratory infection

Genome Medicine
Background Acute sinusitis (AS) is a frequent cause of antibiotic prescriptions in children. Distinguishing bacterial AS from common viral upper respiratory infections (URIs) is crucial to prevent unnecessary antibiotic use but is challenging with ...
Andrew C. Doxey, Nooran Abu Mazen, Max Homm, Vivian Chu, Manjot Hunjan, Briallen Lobb, Sojin Lee, Marcia Kurs-Lasky, John V. Williams, William MacDonald, Monika Johnson, Jeremy A. Hirota, Nader Shaikh   +12 more
doaj   +1 more source

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Modular Architecture of Bacterial RNase P Ribozymes as a Structural Platform for RNA Nanostructure Design

CHIMIA, 2018
Ribonuclease P (RNase P) is a class of enzymes involved in the processing of precursor tRNAs to remove their 5'-leader sequences. Ribonuclease P enzymes are classified into two completely distinct classes, i.e.
Yuri Nozawa, Megumi Hagihara, Shigeyoshi Matsumura, Yoshiya Ikawa   +3 more
doaj   +1 more source

An optimised saliva collection method to produce high-yield, high-quality RNA for translational research.

PLoS ONE, 2020
Saliva represents an ideal matrix for diagnostic biomarker development as it is readily available and requires no invasive collection procedures. However, salivary RNA is labile and rapidly degrades.
Roisin Sullivan, Susan Heavey, David G Graham, Rachel Wellman, Saif Khan, Sri Thrumurthy, Benjamin S Simpson, Tina Baker, Sarah Jevons, Jose Ariza, Victor Eneh, Hayley Pye, Hayley Luxton, Rifat Hamoudi, Hayley Whitaker, Laurence B Lovat   +15 more
doaj   +1 more source

Microrna response of primary human macrophages to Arcobacter Butzleri infection [PDF]

, 2016
The role of microRNAs (miRNAs) in infectious diseases is becoming more and more apparent, and the use of miRNAs as a diagnostic tool and their therapeutic application has become the major focus of investigation.
Alter, Thomas, Backes, Christina, Bruegge, Jennifer zur, Einspanier, Ralf, Franke, Andre, Gölz, Greta, Hemmrich-Stanisak, Georg, Keller, Andreas, Scharek-Tedin, Lydia, Sharbati, Soroush   +9 more
core   +3 more sources

Microbubble‐Controlled Delivery of Biofilm‐Targeting Nanoparticles to Treat MRSA Infection

Advanced Functional Materials, EarlyView.
Here, an effective strategy using microbubble (MB)‐controlled delivery of biofilm‐targeting nanoparticles (BTNs) for removal and therapy of methicillin‐resistant Staphylococcus aureus (MRSA) biofilm infections is introduced. In vivo delivery of MB with BTN is demonstrated to silence key bacterial genes involved in biofilm formation (icaA), bacterial ...
Ju Yeon Chung, Yujin Ahn, Joo Hun Lee, Seungju Yang, Seung Cheol Lee, Hyunjoon Kong, Hyun Jung Chung   +6 more
wiley   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +1 more source

RNA-guided DNA insertion with CRISPR-associated transposases

Science, 2019
Beyond adaptive immunity Prokaryotic CRISPR-Cas systems defend bacterial cells from phage and plasmid infection. Strecker et al. characterized a CRISPR-Cas system that functions beyond adaptive immunity (see the Perspective by Hou and Zhang).
Jonathan Strecker, Alim Ladha, Zachary Gardner, Jonathan L. Schmid-Burgk, K. Makarova, E. Koonin, Feng Zhang   +6 more
semanticscholar   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source