Results 131 to 140 of about 488,336 (199)

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

From Methylomes to CRISPR Epigenetic Editing: New Paths in Antibiotic Resistance. [PDF]

Pathogens
Nass NM, Zaher KA.
europepmc   +1 more source

Ratoon Season Rice Reduces Methane Emissions by Limiting Acetic Acid Transport to the Rhizosphere and Inhibiting Methanogens

Advanced Science, EarlyView.
This study finds that the interaction between ABA‐OsCIPK2‐OsSWEET1A reduces the allocation of methane producing bacteria carbon source (acetic acid) content to the rhizosphere soil of ratoon season rice, thereby reducing methane emissions. Abstract Rice paddies are a major, persistent source of atmospheric methane (CH4), emission rates depend on the ...
Jingnan Zou, Hailong Xu, Bin Qin, Chaojie Lan, Jinying Li, Bianhong Zhang, Huabin Zhang, Chunlin Guo, Hongfei Chen, Zhongming Fang, Quanzhi Zhao, Wenfei Wang, Changxun Fang, Zhixing Zhang, Wenxiong Lin   +14 more
wiley   +1 more source

YhfH functions as a tri-function RNA in Bacillus thuringiensis BMB171. [PDF]

Nucleic Acids Res
Qin J, Cai X, Zhang Y, Wang Z, Pan F, Yan B, Cai J.   +6 more
europepmc   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, EarlyView.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations. [PDF]

Nat Commun
McElderry JP, Zhang T, Zhao W, Hoang PH, Anyaso-Samuel S, Sang J, Khandekar A, Hartman C, Colón-Matos FJ, Miraftab M, Saha M, Lee O, Sharma S, Jones KM, Zhu B, Díaz-Gay M, Mas L, Arrieta O, Edell ES, Santamaría JM, Schabath MB, Yendamuri S, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Janout V, Mates D, Ognjanovic S, Savic M, Kontic M, Bossé Y, Gould Rothberg BE, Christiani DC, Gaborieau V, Brennan P, Liu G, Hofman P, Wong MP, Leung KC, Chen CY, Hsiung CA, Rothman N, Leduc C, Baine MK, Travis WD, Sholl LM, Joubert P, Homer R, Yang SR, Lan Q, Nowak MA, Wedge DC, Alexandrov LB, Chanock SJ, Vogtmann E, Abnet CC, Shi J, Landi MT.   +61 more
europepmc   +1 more source

Ribosome Homeostasis Regulated by SETD2 Preserves Intestinal Epithelial Barrier

Advanced Science, EarlyView.
SETD2 ablation causes dysregulation and recruitment defects of ribosome biogenesis factors, resulting in translational disorders of barrier maintenance genes, thereby compromising the intestinal barrier. These findings unveil a previously unappreciated role of ribosome biogenesis and translational regulation in preserving the intestinal epithelial ...
Hanyu Rao, Aiting Wang, Yue Xu, Wenxin Feng, Chunxiao Ma, Ziyi Wang, Wei Zhang, Wenqiong Su, Xiuying Xiao, Wei‐Qiang Gao, Xianting Ding, Li Li   +11 more
wiley   +1 more source

Developing antisense oligomer biotics "asobiotics" as precision antibacterials: designs, strategies, and considerations for future success. [PDF]

FEMS Microbiol Rev
Moustafa DA, Ghosh C, Jung J, Nanayakkara A, Sapkota M, Nagamatsu K, Geller B, Vogel J, Goldberg JB, Greenberg DE.   +9 more
europepmc   +1 more source

Metformin Impairs Breast Cancer Growth through the Inhibition of PRMT6

Advanced Science, EarlyView.
Metformin has a biological activity against breast cancer. However, it is largely unknown about its precise therapeutic targets. Here, histone arginine methyltransferase PRMT6 is identified as a new anti‐cancer target for metformin. Metformin directly binds PRMT6 and inhibits its ability to catalyze histone H3R2 asymmetric dimethylation (H3R2me2a ...
Yinsheng Wu, Xinlin Xu, Yue Tong, Min Wang, Feng Ge, Min Wu, Yunlong Wang, Gang Chen, Xilan Yu, Shanshan Li   +9 more
wiley   +1 more source

Characterising commensal and pathogenic staphylococcal interactions with neonatal and adult blood. [PDF]

Sci Rep
Joubert IA, Mullally C, Wang P, Chopra A, Strunk T, Currie A.   +5 more
europepmc   +1 more source