Results 211 to 220 of about 477,009 (248)

Gene Editing of a Susceptibility LncRNA Enhances Broad‐Spectrum Disease Resistance in Rice without Developmental Trade‐Offs

Advanced Science, EarlyView.
Editing susceptibility lncRNAs offers a strategy to enhance disease resistance without yield loss. RESIS, a domestication‐acquired, pathogen‐induced lncRNA, promotes protein N‐terminal acetylation through its interaction with NatA complex. Knockout of RESIS increases translation and confers broad‐spectrum resistance to both fungal and bacterial ...
Wen‐long Zhao, Ye Cheng, Jia‐hui Huang, Jun‐jie Feng, Hui‐yin Pang, Yi‐chao Qin, Zheng‐tong Chen, Yu Cheng, Jian‐ping Lian, Yan‐fei Zhou, Rui‐rui He, Meng‐qi Lei, Zi‐qin Cao, Lu Yang, Chao Yuan, Jie Jiang, Yue‐qin Chen, Yu‐chan Zhang   +17 more
wiley   +1 more source

Host-virome associations in the weathering crust of a rapidly retreating temperate Alpine glacier. [PDF]

Microb Genom
Varliero G, Bauder A, Stierli B, Qi W, Frey B.   +4 more
europepmc   +1 more source

Biosynthesis of H2S and Siderophores Targeting Gram‐Negative Bacterial Resistance to Reactive Oxygen Species

Advanced Science, EarlyView.
Discover how Gram‐negative bacteria develop resistance to reactive oxygen species, and how scientists aim to overcome this challenge. Abstract Reactive oxygen species (ROS) are a promising alternative bactericide. However, it is questioned that bacteria can potentially develop resistance to ROS, similar to their resistance against antibiotics and ...
Congyang Mao, Wanyu Jin, Yiming Xiang, Yizhou Zhu, Jun Wu, Xiangmei Liu, Shuilin Wu, Wei Qiao, Kenneth M. C. Cheung, Kelvin Wai Kwok Yeung   +9 more
wiley   +1 more source

An uncharacterized small protein MicN mediates the transcriptional reprogramming of Salmonella through regulating the RpoS-RNA polymerase interaction. [PDF]

Commun Biol
Liu R, Wang Q, Yuan X, Yue Y, Zhang P, Yin K, Wang W, Li B.   +7 more
europepmc   +1 more source

tRNA‐Derived Fragment tRF‐22 Promotes Immunosuppression by Inhibiting HnRNPAB Ubiquitination in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
tRF‐22 fosters an immunosuppressive and pro‐oncogenic tumor microenvironment in ESCC by stabilizing hnRNPAB against TRIM25‐mediated ubiquitination and enhancing TGFβ2 expression, which increases PMN‐MDSCs infiltration and suppresses CD8+ T cells. Targeting tRF‐22 or blocking TGFβ signalling improves anti‐PD1 response, offering a promising therapeutic ...
Ling Pan, Xin Qin, Li Gong, Haining Liu, Bo Cheng, Jing Wang, Yajie Hu, Lingxing Zeng, Yiping Wang, Qingxu Song, Yufeng Cheng   +10 more
wiley   +1 more source

RNA modification is the mark and strategy for host-microbe interactions. [PDF]

Cell Mol Life Sci
Tian Y, Wang X.
europepmc   +1 more source

Guanidine aptamers are present in vertebrate RNAs associated with calcium signaling and neuromuscular function. [PDF]

Nat Commun
Kavita K, Narunsky A, Mohsen JJ, Mahadeshwar I, Mohsen MG, Chang YS, Breaker RR.   +6 more
europepmc   +1 more source

Stool shed cell transcriptomics mirrors tumor biology and enables colorectal cancer diagnosis. [PDF]

Sci Rep
Bahar Halpern K, Kent I, Yakubovsky O, Ben-Moshe S, Barkai T, Fine M, Novoselsky R, Israeli A, Nachmany I, Itzkovitz S.   +9 more
europepmc   +1 more source

Description of bacterial RNA transcripts detected in <i>Mycobacterium tuberculosis</i> - infected cells from peripheral human granulomas. [PDF]

Virulence
Moos PJ, Carey AF, Joseph J, Kialo S, Norrie J, Moyareke JM, Amof A, Nogua H, Lim AL, Barrows LR.   +9 more
europepmc   +1 more source