Results 171 to 180 of about 388,782 (280)

TET dioxygenases localize at splicing speckles and promote RNA splicing. [PDF]

Nucleus
Hastert FD, Weber J, Bauer C, Zhadan A, Singh DND, Dix TC, Arnold R, Bessonov S, Soller M, Leonhardt H, Cardoso MC, Arroyo M.   +11 more
europepmc   +1 more source

A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions. [PDF]

Cell, 2016
Gerson-Gurwitz A, Wang S, Sathe S, Green R, Yeo GW, Oegema K, Desai A.   +6 more
europepmc   +1 more source

Tumor Extracellular Vesicles Aggravate Mitochondrial Damage in Myocardial Ischemia/Reperfusion Injury

Advanced Science, EarlyView.
This study reveals a novel mechanistic connection between cancer and ischemia/reperfusion (I/R)‐induced cardiac injury. The meta‐analysis demonstrates significantly higher incidence ratios of both all‐cause mortality and cardiovascular mortality in cancer patients undergoing percutaneous coronary intervention (PCI) compared to non‐cancer patients.
Zhongting Mei, Qian Liu, Guoxin Liu, Manjie Zhang, Jiaxin Fang, Xuting He, Xueqi He, Zhengwei Qin, Ronghua Liu, Chuang Liu, Hongyu Ji, Yuechao Dong, Ye Yuan, Baofeng Yang, Weijie Du   +14 more
wiley   +1 more source

The PAZ pocket and dimerization drive CpAgo's guide-independent and DNA-guided dual catalysis. [PDF]

Nat Commun
Liu Y, Zhang J, Liu J, Zhang S, An L, Xie W, Zhang K, Li S.   +7 more
europepmc   +1 more source

Targeting Intratumoral Copper Inhibits Tumor Progression via p62‐Mediated EZH2 Degradation and Potentiates Anti‐PD‐1 Immunotherapy in Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin, Wanling Chen, Bo Li, Zhang Zhao, Zhonglin Yu, Xu‐Yun Zhao, Xuan Zhou, Zhien Feng, Chengzhong Lin, Wei Cao   +9 more
wiley   +1 more source

CryoEM structure of the SLFN14 endoribonuclease reveals insight into RNA binding and cleavage. [PDF]

Nat Commun
Van Riper J, Martinez-Claros AO, Wang L, Schneiderman HE, Maheshwari S, Pillon MC.   +5 more
europepmc   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Human CCR4 deadenylase homolog Angel1 is a non-stop mRNA decay factor. [PDF]

RNA
Nicholson-Shaw T, Dowdle ME, Ajaj Y, Perelis M, Fulzele A, Yeo GW, Bennett EJ, Lykke-Andersen J.   +7 more
europepmc   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Next-Generation Protein-Ligand Interaction Networks: APEX as a Powerful Technology. [PDF]

Proteomes
Quintero-Ferrer JM, de Oliveira LS, Goulart PMV, Campos TAS, Martin C, Grellier P, Bastos IMD, Charneau S.   +7 more
europepmc   +1 more source