Results 1 to 10 of about 18,960 (170)
Split intron-exon system for circular RNA synthesis [PDF]
Nature CommunicationsRibozyme-based approaches have been extensively employed for in vitro circular RNA (circRNA) synthesis. However, several critical challenges are impeding the progress in this field, including the relatively low ribozyme utilization efficiency, limited ...
Lei Wang +11 more
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Exonuclease Ribozyme Encoded in a Circular Genome: On the Initiation of the RNA World [PDF]
LifeThe “RNA World” hypothesis posits a reasonable scenario for the origin of life. A question central to this scenario is: which RNA species may have emerged as the first ribozyme, thereby initiating the earliest stage of life?
Minglun Liang +3 more
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Molecules, 2023 The multimolecular assembly of three-dimensionally structured proteins forms their quaternary structures, some of which have high geometric symmetry. The size and complexity of protein quaternary structures often increase in a hierarchical manner, with ...
Mst. Ayesha Siddika +6 more
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Zoonotic Diseases, 2023 Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro.
Bin Yan +4 more
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eLife, 2021 Ribozyme switches are a class of RNA-encoded genetic switch that support conditional regulation of gene expression across diverse organisms. An improved elucidation of the relationships between sequence, structure, and activity can improve our capacity ...
Calvin M Schmidt, Christina D Smolke
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Effective inhibition of human immunodeficiency virus 1 replication by engineered RNase P ribozyme. [PDF]
PLoS ONE, 2012 Using an in vitro selection procedure, we have previously isolated RNase P ribozyme variants that efficiently cleave an mRNA sequence in vitro. In this study, a variant was used to target the HIV RNA sequence in the tat region.
Wenbo Zeng +7 more
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Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
Molecules, 2022 Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization.
Mst. Ayesha Siddika +7 more
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A cell-based ribozyme reporter system employing a chromosomally-integrated 5′ exonuclease gene
BMC Molecular and Cell Biology, 2021 Background Bioinformatic genome surveys indicate that self-cleaving ribonucleic acids (ribozymes) appear to be widespread among all domains of life, although the functions of only a small number have been validated by biochemical methods.
Aiyada Aroonsri +4 more
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Molecular Therapy: Nucleic Acids, 2021 Hepatocellular carcinoma (HCC) has high fatality rate and limited therapeutic options. Here, we propose a new anti-HCC approach with high cancer-selectivity and efficient anticancer effects, based on adenovirus-mediated Tetrahymena group I trans-splicing
Seung Ryul Han +12 more
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Viruses, 2014 RNase P ribozyme can be engineered to be a sequence-specific gene-targeting agent with promising application in both basic research and clinical settings.
Zhu Yang +7 more
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