Results 1 to 10 of about 27,058 (211)

Inhibition of telomerase activity by HDV ribozyme in cancers

Journal of Experimental & Clinical Cancer Research, 2011
Background Telomerase plays an important role in cell proliferation and carcinogenesis and is believed to be a good target for anti-cancer drugs. Elimination of template function of telomerase RNA may repress the telomerase activity.
Gao Yanjing, Jin Dachuan, Gu Junchao, Lu Yingying, Yuan Mengbiao   +4 more
doaj   +1 more source

The Hammerhead Ribozyme: A Long History for a Short RNA

Molecules, 2017
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner.
Marcos de la Peña, Inmaculada García-Robles, Amelia Cervera   +2 more
doaj   +1 more source

Ribozyme activity modulates the physical properties of RNA–peptide coacervates

eLife, 2023
Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay, Elia Salibi, Basusree Ghosh, TY Dora Tang, Hannes Mutschler   +4 more
doaj   +1 more source

Equilibrium properties and force-driven unfolding pathways of RNA molecules

, 2009
The mechanical unfolding of a simple RNA hairpin and of a 236--bases portion of the Tetrahymena thermophila ribozyme is studied by means of an Ising--like model.
A. Imparato, A. Pelizzola, M. Müller, M. Zamparo   +3 more
core   +1 more source

Large Phenotypic Enhancement of Structured Random RNA Pools. [PDF]

, 2020
Laboratory evolution of functional RNAs has applications in many areas of chemical and synthetic biology. In vitro selections critically depend on the presence of functional molecules, such as aptamers and ribozymes, in the starting sequence pools.
Chizzolini, Fabio, Dingilian, Armine I, Lupták, Andrej, Oumais, Mona, Passalacqua, Luiz FM, Szostak, Jack W   +5 more
core  

Functional identification of catalytic metal ion binding sites within RNA. [PDF]

PLoS Biology, 2005
The viability of living systems depends inextricably on enzymes that catalyze phosphoryl transfer reactions. For many enzymes in this class, including several ribozymes, divalent metal ions serve as obligate cofactors.
James L Hougland, Alexander V Kravchuk, Daniel Herschlag, Joseph A Piccirilli   +3 more
doaj   +2 more sources

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries

JHEP Reports, 2023
Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka, Stéphanie Conzelmann, Yves Cambet, Tifany Schaer, Francesco Negro, Sophie Clément   +5 more
doaj   +1 more source

Distribution of graph-distances in Boltzmann ensembles of RNA secondary structures [PDF]

, 2013
Large RNA molecules often carry multiple functional domains whose spatial arrangement is an important determinant of their function. Pre-mRNA splicing, furthermore, relies on the spatial proximity of the splice junctions that can be separated by very ...
A. Kobitski, A.M. Yoffe, A.P. Baraniak, A.X. Li, C.J. McManus, C.M. Reidys, D. Dufour, D. Leipply, D. Mathews, D.H. Mathews, H.S. Han, J.S. McCaskill, K. Darty, L.T. Fang, M. Müller, P. Clote, P. Schuster, R. Das, R. Giegerich, R. Lorenz, R. Lorenz, R. Roy, R.A. Forties, T.R. Einert, U. Gerland, U. Gerland, Y. Ding   +26 more
core   +1 more source

Factorization Machine with Iterative Quantum Reverse Annealing: A Python Package for Batch Black‐Box Optimization With Reverse Quantum Annealing

Advanced Intelligent Discovery, EarlyView.
Factorization machine with iterative quantum reverse annealing (FMIRA) leverages quantum reverse annealing to perform batch black‐box optimization. Factorization machine with quantum annealing (FMQA) is a widely used python package for solving black‐box optimization problems using D‐Wave quantum annealers.
Andrejs Tučs, Ryo Tamura, Koji Tsuda
wiley   +1 more source

Molecular Anatomy of the Class I Ligase Ribozyme for Elucidation of the Activity-Generating Unit

Biology, 2023
The class I ligase ribozyme consists of 121 nucleotides and shows a high catalytic rate comparable to that found in natural proteinaceous polymerases. In this study, we aimed to identify the smaller active unit of the class I ligase ribozyme comprising ...
Miho Kasuga, Hiromi Mutsuro-Aoki, Tadashi Ando, Koji Tamura   +3 more
doaj   +1 more source