Results 1 to 10 of about 392,849 (239)
What RNA World? Why a Peptide/RNA Partnership Merits Renewed Experimental Attention
Life, 2015 We review arguments that biology emerged from a reciprocal partnership in which small ancestral oligopeptides and oligonucleotides initially both contributed rudimentary information coding and catalytic rate accelerations, and that the superior ...
Charles W. Carter
doaj +1 more source
Tag mechanism as a strategy for the RNA replicase to resist parasites in the RNA world. [PDF]
PLoS ONE, 2017 The idea that life may have started with an "RNA world" is attractive. Wherein, a crucial event (perhaps at the very beginning of the scenario) should have been the emergence of a ribozyme that catalyzes its own replication, i.e., an RNA replicase ...
Sanmao Wu +6 more
doaj +1 more source
tRNA Core Hypothesis for the Transition from the RNA World to the Ribonucleoprotein World
Life, 2016 Herein we present the tRNA core hypothesis, which emphasizes the central role of tRNAs molecules in the origin and evolution of fundamental biological processes.
Savio T. de Farias +2 more
doaj +1 more source
Arginine cofactors on the polymerase ribozyme. [PDF]
PLoS ONE, 2011 The RNA world hypothesis states that the early evolution of life went through a stage in which RNA served both as genome and as catalyst. The central catalyst in an RNA world organism would have been a ribozyme that catalyzed RNA polymerization to ...
Chengguo Yao +4 more
doaj +1 more source
One-Pot Formation of Pairing Proto-RNA Nucleotides and Their Supramolecular Assemblies
Life, 2023 Most contemporary theories for the chemical origins of life include the prebiotic synthesis of informational polymers, including strong interpretations of the RNA World hypothesis.
Tyler P. Roche +4 more
doaj +1 more source
Mass Spectrometry-Based Proteomics to Unveil the Non-coding RNA World
Frontiers in Molecular Biosciences, 2018 The interaction between non-coding RNAs (ncRNAs) and proteins is crucial for the stability, localization and function of the different classes of ncRNAs. Although ncRNAs, when embedded in various ribonucleoprotein (RNP) complexes, control the fundamental
Roberto Giambruno +2 more
doaj +1 more source
The Fascinating World of RNA Interference
International Journal of Biological Sciences, 2009 Micro- and short-interfering RNAs represent small RNA family that are the recognized as critical regulatory species across the eukaryotes. Recent high-throughput sequencing have revealed two more hidden players of the cellular small RNA pool. Reported in
Afsar Raza Naqvi, Md. Nazrul Islam, Nirupam Roy Choudhury, Qazi Mohd. Rizwanul Haq.
doaj
The RNA World: Piecing together the historical development of a hypothesis
Mètode Science Studies Journal: Annual Review, 2016 The concept of an RNA world is a hypothesis firmly rooted in empirical data and is part of a long and complex scientific perspective that goes back more than fifty years to the discovery of the central role RNA and ribonucleotides play in protein ...
Antonio Lazcano
doaj +1 more source
Pioneering role of RNA in the early evolution of life [PDF]
Genetics and Molecular BiologyThe catalytic, regulatory and structural properties of RNA, combined with their extraordinary ubiquity in cellular processes, are consistent with the proposal that this molecule played a much more conspicuous role in heredity and metabolism during the ...
Israel Muñoz-Velasco +6 more
doaj +1 more source
Comparative analysis of RNA families reveals distinct repertoires for each domain of life.
PLoS Computational Biology, 2012 The RNA world hypothesis, that RNA genomes and catalysts preceded DNA genomes and genetically-encoded protein catalysts, has been central to models for the early evolution of life on Earth.
Marc P Hoeppner +2 more
doaj +1 more source