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RNA World with Inhibitors [PDF]
EntropyDuring the evolution of the RNA World, compartments, which were fragments of space surrounded by a primitive lipid membrane, had to have emerged. These led eventually to the formation of modern cellular membranes.
Jaroslaw Synak +3 more
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From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution [PDF]
Cells, 2021 The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are ...
Zachary W. Kockler, Dmitry A. Gordenin
doaj +5 more sources
Kin Selection in the RNA World [PDF]
Life, 2017 Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions.
Samuel R. Levin, Stuart A. West
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Order and Complexity in the RNA World [PDF]
Life, 2023 The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution.
Christian Mayer
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RNA World Modeling: A Comparison of Two Complementary Approaches [PDF]
Entropy, 2022 The origin of life remains one of the major scientific questions in modern biology. Among many hypotheses aiming to explain how life on Earth started, RNA world is probably the most extensively studied.
Jaroslaw Synak +2 more
doaj +2 more sources
Rethinking the tools of the RNA world [PDF]
eLife, 2018 An artificially evolved ribozyme can catalyse the synthesis of RNA by using trinucleotide triphosphates as building blocks.
Antony Crisp, Thomas Carell
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The RNA world of fungal pathogens. [PDF]
PLoS Pathogens, 2023 Srimeenakshi Sankaranarayanan +3 more
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RNA Synthesis by in Vitro Selected Ribozymes for Recreating an RNA World
Life, 2015 The RNA world hypothesis states that during an early stage of life, RNA molecules functioned as genome and as the only genome-encoded catalyst. This hypothesis is supported by several lines of evidence, one of which is the in vitro selection of catalytic
Lyssa L. Martin +2 more
doaj +3 more sources
Reviving the RNA world: An insight into the appearance of RNA methyltransferases
Frontiers in Genetics, 2016 RNA, the earliest genetic and catalytic molecule, has a relatively delicate and labile chemical structure, when compared to DNA. It is prone to be damaged by alkali, heat, nucleases or stress conditions. One mechanism to protect RNA or DNA from damage is
Ajay Kumar Rana, Serge eAnkri
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Transitioning to DNA genomes in an RNA world [PDF]
eLife, 2017 The unexpected ability of an RNA polymerase ribozyme to copy RNA into DNA has ramifications for understanding how DNA genomes evolved.
Razvan Cojocaru, Peter J Unrau
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