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Kin Selection in the RNA World [PDF]
Life, 2017 Various steps in the RNA world required cooperation. Why did life’s first inhabitants, from polymerases to synthetases, cooperate? We develop kin selection models of the RNA world to answer these questions.
Samuel R. Levin, Stuart A. West
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RNA silencing sheds light on the RNA world. [PDF]
PLoS Biology, 2006 RNA silencing — also known as RNA interference — is an intriguing phenomenon in which short, double-stranded RNA “triggers” can prevent the expression of specific genes. First discovered in plants, RNA interference is now recognized as a widespread, if not ubiquitous, phenomenon, and it is causing great excitement as an experimental technique for ...
Rachel Jones
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EntropyDuring the evolution of the RNA World, compartments, which were fragments of space surrounded by a primitive lipid membrane, had to have emerged. These led eventually to the formation of modern cellular membranes.
Jaroslaw Synak +3 more
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Chaperna: linking the ancient RNA and protein worlds
RNA Biology, 2021 As a mental framework for the transition of self-replicating biological forms, the RNA world concept stipulates a dual function of RNAs as genetic substance and catalyst.
Ahyun Son, Scott Horowitz, Baik L. Seong
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A Polyaddition Model for the Prebiotic Polymerization of RNA and RNA-Like Polymers
Life, 2020 Implicit in the RNA world hypothesis is that prebiotic RNA synthesis, despite occurring in an environment without biochemical catalysts, produced the long RNA polymers which are essential to the formation of life.
Alex Spaeth, Mason Hargrave
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The Origins of the RNA World [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The general notion of an "RNA World" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA and genetically encoded proteins were not involved as catalysts. There is now strong evidence indicating that an RNA World did indeed exist before DNA- and protein-based life. However, arguments regarding
Michael P, Robertson, Gerald F, Joyce
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Order and Complexity in the RNA World
Life, 2023 The basic idea of the RNA world as an early step towards life relies on a molecular evolution process based on self-replicating RNA strands. It is probably the oldest and most convincing model for efficient prebiotic evolution.
Christian Mayer
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Journal of Cell Science, 2003 Small RNAs have burst on the scene as ubiquitous, versatile repressors of gene expression in plants, animals and many fungi. These tiny RNAs (∼21-26 nt), which induce silencing through homologous sequence interactions, come in many guises: short interfering (si) RNAs ([Elbashir et al., 2001][1]),
E Jean, Finnegan, Marjori A, Matzke
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From RNA World to SARS-CoV-2: The Edited Story of RNA Viral Evolution
Cells, 2021 The current SARS-CoV-2 pandemic underscores the importance of understanding the evolution of RNA genomes. While RNA is subject to the formation of similar lesions as DNA, the evolutionary and physiological impacts RNA lesions have on viral genomes are ...
Zachary W. Kockler, Dmitry A. Gordenin
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Annual Review of Plant Biology, 2023 My research career started with an ambition to work out how genes are regulated in plants. I tried out various experimental systems—artichoke tissue culture in Edinburgh; soybean root nodules in Montreal; soybean hypocotyls in Athens, Georgia; and cereal aleurones in Cambridge—but eventually I discovered plant viruses.
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