Results 31 to 40 of about 392,849 (239)
Journal of Cell Science, 2003 Small RNAs have burst on the scene as ubiquitous, versatile repressors of gene expression in plants, animals and many fungi. These tiny RNAs (∼21-26 nt), which induce silencing through homologous sequence interactions, come in many guises: short interfering (si) RNAs ([Elbashir et al., 2001][1]),
E Jean, Finnegan, Marjori A, Matzke
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Annual Review of Plant Biology, 2023 My research career started with an ambition to work out how genes are regulated in plants. I tried out various experimental systems—artichoke tissue culture in Edinburgh; soybean root nodules in Montreal; soybean hypocotyls in Athens, Georgia; and cereal aleurones in Cambridge—but eventually I discovered plant viruses.
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The Origins of the RNA World [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 The general notion of an "RNA World" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA and genetically encoded proteins were not involved as catalysts. There is now strong evidence indicating that an RNA World did indeed exist before DNA- and protein-based life. However, arguments regarding
Michael P, Robertson, Gerald F, Joyce
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Lipid-Assisted Polymerization of Nucleotides
Life, 2019 In addition to being one of the proponents of the “Lipid World hypothesis”, David Deamer, together with other colleagues, pioneered studies involving formation of RNA-like oligomers from their ‘non-activated’, prebiotically ...
Felix Olasagasti, Sudha Rajamani
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Life, 2023 How functional peptides may have arisen is a significant problem for the scenario of the RNA world. An attractive idea, the direct RNA template (DRT) hypothesis, proposes that RNA molecules can bind amino acids specifically and promote the synthesis of ...
Yu Shi, Chunwu Yu, Wentao Ma
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Genetics and Molecular Biology, 2014 One of the major developments that resulted from the human genome sequencing projects was a better understanding of the role of non-coding RNAs (ncRNAs). NcRNAs are divided into several different categories according to size and function; however, one shared feature is that they are not translated into proteins. In this review, we will discuss relevant
Dogini, Danyella Barbosa +5 more
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Methanol in the RNA world: An astrochemical perspective
Frontiers in Astronomy and Space Sciences, 2022 The role and relevance of methanol in the origin and structure of the RNA world is discussed. Methanol is a pivotal, renewable, and regenerable source from which almost all chemical materials, simple or complex, can be accessed.
Thomas Mathew +2 more
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Reflections on the RNA world [PDF]
RNA, 2015 The authors of these reflections are a generation apart, yet their career paths have much in common. After training in medicine, they both followed the call of “real science” to discover a passion for the world of RNAs, a little corner of which they are now exploring jointly. This is a brief account of these meanderings.
Zavolan, Mihaela, Keller, Walter
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Acta Societatis Botanicorum Poloniae, 2014 Among the numerous hypotheses offering a scenario for the origin of life on Earth, the one called “The RNA World” has gained the most attention. According to this hypothesis RNA acted as a genetic information storage material, as a catalyst of all ...
Zofia Szweykowska-Kulińska
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The new world of RNA diagnostics and therapeutics
Journal of Experimental & Clinical Cancer Research, 2023 The 5th Workshop IRE on Translational Oncology was held in Rome (Italy) on 27–28 March at the IRCCS Regina Elena National Cancer Institute. This meeting entitled “The New World of RNA diagnostics and therapeutics” highlightes the significant progress in ...
Giovanni Blandino +18 more
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