Results 41 to 50 of about 392,849 (239)
The RNA Worlds in Context [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 There are two RNA worlds. The first is the primordial RNA world, a hypothetical era when RNA served as both information and function, both genotype and phenotype. The second RNA world is that of today's biological systems, where RNA plays active roles in catalyzing biochemical reactions, in translating mRNA into proteins, in regulating gene expression,
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Traversing the RNA world. [PDF]
J Biol Chem, 2017 An invitation to write a "Reflections" type of article creates a certain ambivalence: it is a great honor, but it also infers the end of your professional career. Before you vanish for good, your colleagues look forward to an interesting but entertaining account of the ups-and-downs of your past research and your views on science in general, peppered ...
Filipowicz W.
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Evolution in an RNA World [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2009 A long-standing research goal has been to develop a self-sustained chemical system that is capable of undergoing Darwinian evolution. The notion of primitive RNA-based life suggests that this goal might be achieved by constructing an RNA enzyme that catalyzes the replication of RNA molecules, including the RNA enzyme itself.
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The RNA World: 4,000,000,050 years old
Life, 2015 The RNA World is now some four billion years behind us, but only recently turned 50 as a human hypothesis. [...]
Niles Lehman
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RNA, 2015 My research entered the RNA world when I joined the EMBL Heidelberg. During my doctoral and postdoctoral research I had focused on developing and applying solution NMR methods and studied protein structure and dynamics of the Bcl family proteins, which are important regulators of apoptosis.
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Os semimetais na origem e evolução da vida
Química Nova, 2012 Metalloids have characteristics between metals and non-metals which give them, in some cases, specific properties. At least two of this chemical elements, boron and silicon, are essential to a significant number of living organisms and since some years ...
Manuel Aureliano +3 more
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Key steps from the “RNA World” to the “DNA World”
BIO Web of Conferences, 2014 In the « RNA World » hypothesis of the origin of life, RNAs are assumed to be the central macromolecules able to self-replicate, conserve information and catalyze the reactions necessary for a primitive metabolism and many enzymatic cofactors may be ...
Renard B.-L. +3 more
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RNA, 2013 Following the naming of the RNA World for the hypothetical biochemical world during very early life forms, the current world was named the Protein World. However, the astonishing high level of transcripts from virtually all chromosomes in an organism now found in eucaryotes, as well as their extensive roles in regulating gene expression, suggests that ...
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Riboswitches and the RNA World [PDF]
Cold Spring Harbor Perspectives in Biology, 2010 Riboswitches are structured noncoding RNA domains that selectively bind metabolites and control gene expression (Mandal and Breaker 2004a; Coppins et al. 2007; Roth and Breaker 2009). Nearly all examples of the known riboswitches reside in noncoding regions of messenger RNAs where they control transcription or translation.
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Pediatric Blood &Cancer, EarlyView.ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider +15 more
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