Results 1 to 10 of about 4,362,156 (310)

Gene Targeting in Disease Networks [PDF]

Frontiers in Genetics, 2021
Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for the characterization of clinical phenotypes and the identification of disease subtypes. Analyses of these data are becoming ever more sophisticated
Deborah Weighill, Marouen Ben Guebila, Kimberly Glass, Kimberly Glass, Kimberly Glass, John Platig, John Platig, Jen Jen Yeh, John Quackenbush, John Quackenbush   +9 more
doaj   +6 more sources

Therapeutic gene targeting [PDF]

Gene Therapy, 1998
Gene targeting is the use of homologous recombination to make defined alterations to the genome. One of the possible outcomes of gene targeting is the accurate correction of genetic defects, and this would make it the ideal method of gene therapy for single gene disorder.
A C Porter
exaly   +3 more sources

Gene-carried hepatoma targeting complex induced high gene transfection efficiency with low toxicity and significant antitumor activity

International Journal of Nanomedicine, 2012
Qing-Qing Zhao,1,2 Yu-Lan Hu,1 Yang Zhou,3 Ni Li,1 Min Han,1 Gu-Ping Tang,4 Feng Qiu,2 Yasuhiko Tabata,5 Jian-Qing Gao,11Institute of Pharmaceutics, Zhejiang University, Hangzhou, China; 2Department of Pharmacy, The First Affiliated Hospital of Chongqing
Zhao QQ, Hu YL, Zhou Y, Li N, Han M, Tang GP, Qiu F, Tabata Y, Gao JQ   +8 more
doaj   +1 more source

Gene targeting in plants [PDF]

The EMBO Journal, 1987
Although the generation of transgenic plants is now routine, the integration of foreign genetic information has so far been at random sites in the genome. We now present evidence for directed integration into a predicted location in the host plant genome.
J, Paszkowski, M, Baur, A, Bogucki, I, Potrykus   +3 more
openaire   +2 more sources

CRISPR/Cas9-Mediated Multi-Allelic Gene Targeting in Sugarcane Confers Herbicide Tolerance

Frontiers in Genome Editing, 2021
Sugarcane is the source of 80% of the sugar and 26% of the bioethanol produced globally. However, its complex, highly polyploid genome (2n = 100 – 120) impedes crop improvement. Here, we report efficient and reproducible gene targeting (GT) in sugarcane,
Mehmet Tufan Oz, Mehmet Tufan Oz, Angelika Altpeter, Ratna Karan, Aldo Merotto, Fredy Altpeter, Fredy Altpeter   +6 more
doaj   +1 more source

Leucine-Rich Repeats and Transmembrane Domain 2 Controls Protein Sorting in the Striatal Projection System and Its Deficiency Causes Disturbances in Motor Responses and Monoamine Dynamics

Frontiers in Molecular Neuroscience, 2022
The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency causes ...
Misato Ichise, Misato Ichise, Kazuto Sakoori, Kei-ichi Katayama, Naoko Morimura, Kazuyuki Yamada, Hiroki Ozawa, Hayato Matsunaga, Minoru Hatayama, Minoru Hatayama, Jun Aruga, Jun Aruga   +11 more
doaj   +1 more source

Constitutive and conditional gene knockout mice for the study of intervertebral disc degeneration: Current status, decision considerations, and future possibilities

JOR Spine, 2023
There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu, Peng‐Bo Chen, Qing‐Yin Xu, Bo Li, Sheng‐Dan Jiang, Lei‐Sheng Jiang, Xin‐Feng Zheng   +6 more
doaj   +1 more source

KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility

FASEB BioAdvances, 2021
Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic modifier that ...
Takeshi Ueda, Akinori Kanai, Akiyoshi Komuro, Hisayuki Amano, Kazushige Ota, Masahiko Honda, Masahito Kawazu, Hitoshi Okada   +7 more
doaj   +1 more source

Rhes depletion promotes striatal accumulation and aggregation of mutant huntingtin in a presymptomatic HD mouse model

Frontiers in Aging Neuroscience, 2023
IntroductionHuntington’s disease (HD) is caused by CAG trinucleotide repeats in the HTT gene. Selective neurodegeneration in the striatum is prominent in HD, despite widespread expression of mutant HTT (mHTT).
Yongcheng Pan, Yongcheng Pan, Beisha Tang, Beisha Tang, Beisha Tang, Xiao-Jiang Li, Shihua Li, Shihua Li, Qiong Liu, Qiong Liu   +9 more
doaj   +1 more source

Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]

, 2014
With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves, Verge, Valerie, Carré, Isabelle A., Schatt, Philippe, Botebol, Hugo, Blain, Stephane, Lozano, Jean-Claude, Lesuisse, Emmanuel, Carré, Isabelle A   +8 more
core   +1 more source