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Gene Targeting in Disease Networks [PDF]
Frontiers in Genetics, 2021 Profiling of whole transcriptomes has become a cornerstone of molecular biology and an invaluable tool for the characterization of clinical phenotypes and the identification of disease subtypes. Analyses of these data are becoming ever more sophisticated
Deborah Weighill +9 more
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Establishment of a stable transfection and gene targeting system in Babesia divergens [PDF]
Frontiers in Cellular and Infection Microbiology, 2023 Babesia divergens is an emerging tick-borne pathogen considered as the principal causative agent of bovine babesiosis in Europe with a notable zoonotic risk to human health. Despite its increasing impact, considerable gaps persist in our understanding of
Eliana F. G. Cubillos +9 more
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Therapeutic gene targeting [PDF]
Gene Therapy, 1998 Gene targeting is the use of homologous recombination to make defined alterations to the genome. One of the possible outcomes of gene targeting is the accurate correction of genetic defects, and this would make it the ideal method of gene therapy for single gene disorder.
Andrew C G Porter
exaly +3 more sources
Gene targeting in plants [PDF]
The EMBO Journal, 1987 Although the generation of transgenic plants is now routine, the integration of foreign genetic information has so far been at random sites in the genome. We now present evidence for directed integration into a predicted location in the host plant genome.
J, Paszkowski +3 more
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CRISPR/Cas9-Mediated Multi-Allelic Gene Targeting in Sugarcane Confers Herbicide Tolerance
Frontiers in Genome Editing, 2021 Sugarcane is the source of 80% of the sugar and 26% of the bioethanol produced globally. However, its complex, highly polyploid genome (2n = 100 – 120) impedes crop improvement. Here, we report efficient and reproducible gene targeting (GT) in sugarcane,
Mehmet Tufan Oz +6 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2022 The striatum is involved in action selection, and its disturbance can cause movement disorders. Here, we show that leucine-rich repeats and transmembrane domain 2 (Lrtm2) controls protein sorting in striatal projection systems, and its deficiency causes ...
Misato Ichise +11 more
doaj +1 more source
JOR Spine, 2023 There have been an increasing number of patients with degenerative disc diseases due to the aging population. In light of this, studies on the pathogenesis of intervertebral disc degeneration have become a hot topic, and gene knockout mice have become a ...
Ze‐Yu Lu +6 more
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Gene targeting in livestock [PDF]
Bioscientifica Proceedings, 2019 The development of nuclear transfer from tissue culture cells in livestock made it possible in principle to produce animals with subtle, directed genetic changes by in vitro modification of nuclear donor cells. In the short period since nuclear transfer was first performed, gene targeting in livestock has become a reality.
A J, Thomson, M M, Marques, J, McWhir
openaire +2 more sources
The effect of primer choice and short read sequences on the outcome of 16S rRNA gene based diversity studies [PDF]
, 2013 Different regions of the bacterial 16S rRNA gene evolve at different evolutionary rates. The scientific outcome of short read sequencing studies therefore alters with the gene region sequenced.
De Vos, Paul +4 more
core +6 more sources
KDM4B promotes acute myeloid leukemia associated with AML1‐ETO by regulating chromatin accessibility
FASEB BioAdvances, 2021 Epigenetic alterations of chromatin structure affect chromatin accessibility and collaborate with genetic alterations in the development of cancer. Lysine demethylase 4B (KDM4B) has been identified as a JmjC domain‐containing epigenetic modifier that ...
Takeshi Ueda +7 more
doaj +1 more source