Results 11 to 20 of about 4,362,156 (310)

Gene targeting in livestock [PDF]

Bioscientifica Proceedings, 2019
The development of nuclear transfer from tissue culture cells in livestock made it possible in principle to produce animals with subtle, directed genetic changes by in vitro modification of nuclear donor cells. In the short period since nuclear transfer was first performed, gene targeting in livestock has become a reality.
A J, Thomson, M M, Marques, J, McWhir
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RNase P Ribozyme Effectively Inhibits Human CC-Chemokine Receptor 5 Expression and Human Immunodeficiency Virus 1 Infection

Zoonotic Diseases, 2023
Developing novel antiviral agents and approaches is essential for the treatment against human and zoonotic viruses. We had previously produced RNase P-based ribozyme variants capable of efficiently cleaving mRNA in vitro.
Bin Yan, Yujun Liu, Yuan-Chuan Chen, Isadora Zhang, Fenyong Liu   +4 more
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The magnetofection method: Using magnetic force to enhance gene delivery [PDF]

, 2003
In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles.
Remy, J. (Jean-Serge), Lausier, J. (Jim), Schillinger, U. (Ulrike), Scherer, F., Rosenecker, J., Anton, M. (Marina), Plank, C., Schillinger, U., Rémy, J.-S., Rosenecker, J. (Joseph), Krötz, F. (Florian), Lausier, J., Scherer, F. (Franz), Bergemann, C., Plank, C. (Christian), Anton, M., Krötz, F., Bergemann, C. (Christian)   +17 more
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"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]

, 2005
The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
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Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids1

Journal of Lipid Research, 2000
UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Hirokazu Fujimoto, Kunihiko Suzuki, Kohji Motegi, Ineo Ishizuka   +5 more
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Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]

Journal of Lipid Research, 2018
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk   +7 more
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Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection [PDF]

, 2008
Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell.
Rosso, L., Kaessmann, H., Marques, A.C., Reichert, A.S., Ana C. Marques, Lia Rosso, Reichert, Andreas, Kaessmann, Henrik, Kaessmann, H, Marques, AC, Henrik Kaessmann, Marques, Ana C., Andreas S. Reichert, Rosso, Lia, Reichert, AS, Ana C Marques, Andreas S Reichert, Rosso, L   +17 more
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2017
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
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Disruption of the Schizosaccharomyces japonicus lig4 Disturbs Several Cellular Processes and Leads to a Pleiotropic Phenotype

Journal of Fungi, 2023
Gene targeting is a commonly used method to reveal the function of genes. Although it is an attractive tool for molecular studies, it can frequently be a challenge because its efficiency can be low and it requires the screening of a large number of ...
Lajos Acs-Szabo, Laszlo Attila Papp, Szonja Takacs, Ida Miklos   +3 more
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Targeting Epilepsy Genes [PDF]

Neuron, 1996
In medieval art it was traditional to show a demon emanating from a suffering epileptic at the conclusion of a seizure, with concern clearly evident regarding its inevitable reappearance. In this century, anticonvulsant drugs have been developed for their ability to control, rather than prevent or reverse, seizure disorders.
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