Gene-carried hepatoma targeting complex induced high gene transfection efficiency with low toxicity and significant antitumor activity [PDF]
International Journal of Nanomedicine, 2012 Qing-Qing Zhao,1,2 Yu-Lan Hu,1 Yang Zhou,3 Ni Li,1 Min Han,1 Gu-Ping Tang,4 Feng Qiu,2 Yasuhiko Tabata,5 Jian-Qing Gao,11Institute of Pharmaceutics, Zhejiang University, Hangzhou, China; 2Department of Pharmacy, The First Affiliated Hospital of Chongqing
Zhao QQ +8 more
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RNA-based gene targeting therapies for human papillomavirus driven cancers [PDF]
, 2021 While platinum-based chemotherapy, radiation therapy and or surgery are effective in reducing human papillomavirus (HPV) driven cancer tumours, they have some significant drawbacks, including low specificity for tumour, toxicity, and severe adverse ...
Supramaniam, Aroon +3 more
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Designing gRNAs targeting oil palm phytoene desaturase (EgPDS) gene and construction of vectors for oil palm CRISPR/Cas9 study [PDF]
, 2022 The CRISPR/Cas9 system is a precise and versatile genetic tool used to induce site-specific manipulation in the targeted gene. This study elaborates on the strategy to select the gRNAs targeting the oil palm phytoene desaturase (EgPDS) gene, which ...
Shaharuddin, Noor Azmi +6 more
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Efficient gene targeting and foreign DNA removal by homologous recombination in the picoeukaryote Ostreococcus [PDF]
, 2014 With fewer than 8000 genes and a minimalist cellular organization, the green picoalga Ostreococcus tauri is one of the simplest photosynthetic eukaryotes. Ostreococcus tauri contains many plant-specific genes but exhibits a very low gene redundancy.
Bouget, Francois-Yves +8 more
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The magnetofection method: Using magnetic force to enhance gene delivery [PDF]
, 2003 In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles.
Remy, J. (Jean-Serge) +17 more
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Journal of Lipid Research, 2000 UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi +5 more
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"In vitro" and "in vivo" drug targeting using biotinylated immunoliposomes [PDF]
, 2005 The aim of my thesis was the optimization, characterization and application of a new, innovative drug carrier system which can be used to target pharmaceuticals to diseased tissues and organs.
Schnyder, Anita
core +1 more source
Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]
Journal of Lipid Research, 2018 Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li +7 more
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Mitochondrial targeting adaptation of the hominoid-specific glutamate dehydrogenase driven by positive Darwinian selection [PDF]
, 2008 Many new gene copies emerged by gene duplication in hominoids, but little is known with respect to their functional evolution. Glutamate dehydrogenase (GLUD) is an enzyme central to the glutamate and energy metabolism of the cell.
Rosso, L. +17 more
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Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface
Nature Communications, 2017 Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang +12 more
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