Results 31 to 40 of about 4,362,156 (310)
G3: Genes, Genomes, Genetics, 2019 Precise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context.
Aaron J. Storey +4 more
doaj +1 more source
Enhancing HR Frequency for Precise Genome Editing in Plants
Frontiers in Plant Science, 2022 Gene-editing tools, such as Zinc-fingers, TALENs, and CRISPR-Cas, have fostered a new frontier in the genetic improvement of plants across the tree of life.
Hao Chen +4 more
doaj +1 more source
Journal of Lipid Research, 1999 In subjects with familial hypobetalipoproteinemia heterozygous for truncated forms of apolipoprotein B, both apoB-100 and the truncated forms are produced at lower than expected rates.
Rai Ajit K. Srivastava +4 more
doaj +1 more source
An Engineering Approach to Cancer Therapy Using Systemically Delivered siRNA [PDF]
, 2007 The next generation of cancer therapeutics will specifically target processes responsible for the growth and survival of cancer cells. Among the most promising of these molecularly targeted therapeutics are small interfering RNAs (siRNAs). These siRNAs
Bartlett, Derek William
core +1 more source
RNA-based gene targeting therapies for human papillomavirus driven cancers
, 2021 While platinum-based chemotherapy, radiation therapy and or surgery are effective in reducing human papillomavirus (HPV) driven cancer tumours, they have some significant drawbacks, including low specificity for tumour, toxicity, and severe adverse ...
Supramaniam, Aroon +3 more
core +1 more source
Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]
, 2012 In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610) +8 more
core +1 more source
Association of the AFF3 gene and IL2/IL21 gene region with juvenile idiopathic arthritis [PDF]
, 2010 Recent genetic studies have led to identification of numerous loci that are associated with susceptibility to autoimmune diseases. The strategy of using information from these studies has facilitated the identification of novel juvenile idiopathic ...
S Eyre +21 more
core +1 more source
Frontiers in Microbiology, 2018 Lipophosphoglycan (LPG) is the major surface glycoconjugate of metacyclic Leishmania promastigotes and is associated with virulence in various species of this parasite.
Milena Lázaro-Souza +18 more
doaj +1 more source
Targeting in Gene Therapy for Gliomas [PDF]
Archives of Neurology, 1999 Cancer is a disease of a series of genes. Thus, theoretically, brain tumors could be treated by targeting their fundamental molecular defects. Currently, most of the approved clinical protocols for gene therapy involve cancer patients. Several of these protocols are designed to improve the treatment of brain tumors. In this brief report, we analyze the
Fueyo, J. +3 more
openaire +3 more sources
, 2022 The CRISPR/Cas9 system is a precise and versatile genetic tool used to induce site-specific manipulation in the targeted gene. This study elaborates on the strategy to select the gRNAs targeting the oil palm phytoene desaturase (EgPDS) gene, which ...
Shaharuddin, Noor Azmi +6 more
core +1 more source