Results 31 to 40 of about 1,207,125 (312)

Tropism-modification strategies for targeted gene delivery using adenoviral vectors [PDF]

, 2010
Achieving high efficiency, targeted gene delivery with adenoviral vectors is a long-standing goal in the field of clinical gene therapy. To achieve this, platform vectors must combine efficient retargeting strategies with detargeting modifications to ...
Coughlan, L., Raul Alba, Coughlan, Lynda, Mcneish, I.A., Andrew H. Baker, Iain A. McNeish, Alba, R., Lynda Coughlan, Parker, Alan L., Nicklin, Stuart A., Bradshaw, Angela C., Bradshaw, A.C., Nicklin, S., Angela C. Bradshaw, Alan L. Parker, Stuart A. Nicklin, McNeish, Iain A., Baker, Andrew H., Parker, A.L., Alba, Raul, Baker, A.   +20 more
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Reprogramming Hansenula polymorpha for penicillin production: expression of the Penicillium chrysogenum pcl gene [PDF]

, 2007
We aim to introduce the penicillin biosynthetic pathway into the methylotrophic yeast Hansenula polymorpha. To allow simultaneous expression of the multiple genes of the penicillin biosynthetic pathway, additional markers were required.
Ida J. van der Klei, Loknath Gidijala, Kiel, Jan A. K. W., Gidijala, Loknath, Klei, Ida J. van der,, van der Klei, Ida J., Jan A.K.W. Kiel, Veenhuis, Marten,, Gidijala, Loknath,, Kiel, Jan A.K.W.,, Marten Veenhuis, Veenhuis, Marten, van der Klei, Ida J.; id_orcid   +12 more
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Targeted Forward Genetics: Population-Scale Analyses of Allele Replacements Spanning Thousands of Base Pairs in Fission Yeast

G3: Genes, Genomes, Genetics, 2019
Precise allele replacement (genome editing), without unwanted changes to the genome, provides a powerful tool to define the functions of DNA elements and encoded factors in their normal biological context.
Aaron J. Storey, Hsin-Ping Wang, Reine U. Protacio, Mari K. Davidson, Wayne P. Wahls   +4 more
doaj   +1 more source

Enhancing HR Frequency for Precise Genome Editing in Plants

Frontiers in Plant Science, 2022
Gene-editing tools, such as Zinc-fingers, TALENs, and CRISPR-Cas, have fostered a new frontier in the genetic improvement of plants across the tree of life.
Hao Chen, Hao Chen, Matthew Neubauer, Jack P. Wang, Jack P. Wang   +4 more
doaj   +1 more source

Targeting in Gene Therapy for Gliomas [PDF]

Archives of Neurology, 1999
Cancer is a disease of a series of genes. Thus, theoretically, brain tumors could be treated by targeting their fundamental molecular defects. Currently, most of the approved clinical protocols for gene therapy involve cancer patients. Several of these protocols are designed to improve the treatment of brain tumors. In this brief report, we analyze the
Fueyo, J., Gomez-Manzano, C., Yung, W. K., Kyritsis, A. P.   +3 more
openaire   +3 more sources

Molecular bases of low production rates of apolipoprotein B-100 and truncated apoB-82 in a mutant HepG2 cell line generated by targeted modification of the apolipoprotein B gene

Journal of Lipid Research, 1999
In subjects with familial hypobetalipoproteinemia heterozygous for truncated forms of apolipoprotein B, both apoB-100 and the truncated forms are produced at lower than expected rates.
Rai Ajit K. Srivastava, Neelam Srivastava, Maurizio Averna, Angelo B. Cefalu, Gustav Schonfeld   +4 more
doaj   +1 more source

An Engineering Approach to Cancer Therapy Using Systemically Delivered siRNA [PDF]

, 2007
The next generation of cancer therapeutics will specifically target processes responsible for the growth and survival of cancer cells. Among the most promising of these molecularly targeted therapeutics are small interfering RNAs (siRNAs). These siRNAs
Bartlett, Derek William
core   +1 more source

Establishing an efficient gene-targeting system in an itaconic-acid producing Aspergillus terreus strain [PDF]

, 2016
To develop an efficient gene-targeting platform in an excellent itaconic acid producing strain Aspergillus terreus CICC40205.
Huang, Xuenian, Chen, Mei, Li, Jianjun, Lu, Xuefeng   +3 more
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Gene targeting in Arabidopsis

The Plant Journal, 2001
Summary Precise modification by gene targeting (GT) provides an important tool for studies of gene function in vivo . Although routine with many organisms, only isolated examples of GT events have been reported for flowering plants.
Hanin, M., Volrath, S., Bogucki, A., Briker, M., Ward, E., Paszkowski, Jerzy   +5 more
openaire   +3 more sources

Targeting the acute promyelocytic leukemia-associated fusion proteins PML/RARα and PLZF/RARα with interfering peptides [PDF]

, 2012
In acute promyelocytic leukemia (APL), hematopoietic differentiation is blocked and immature blasts accumulate in the bone marrow and blood. APL is associated with chromosomal aberrations, including t(15;17) and t(11;17).
Sabine Beez (123610), Beez, Sabine, Philipp Demmer, Elena Puccetti (66633), Philipp Demmer (123611), Puccetti, Elena, Elena Puccetti, Sabine Beez, Demmer, Philipp   +8 more
core   +1 more source