Results 21 to 30 of about 1,132,364 (264)

Kidney lipids in galactosylceramide synthase-deficient mice: absence of galactosylsulfatide and compensatory increase in more polar sulfoglycolipids1

Journal of Lipid Research, 2000
UDP-galactose:ceramide galactosyltransferase (CGT) catalyzes the final step in the synthesis of galactosylceramide (GalCer). It has previously been shown that CGT-deficient mice do not synthesize GalCer and its sulfated derivative GalCer I3-sulfate ...
Keiko Tadano-Aritomi, Toshiyuki Hikita, Hirokazu Fujimoto, Kunihiko Suzuki, Kohji Motegi, Ineo Ishizuka   +5 more
doaj   +1 more source

Flipping the cyclooxygenase (Ptgs) genes reveals isoform-specific compensatory functions1,2[S]

Journal of Lipid Research, 2018
Two prostaglandin (PG) H synthases encoded by Ptgs genes, colloquially known as cyclooxygenase (COX)-1 and COX-2, catalyze the formation of PG endoperoxide H2, the precursor of the major prostanoids.
Xinzhi Li, Liudmila L. Mazaleuskaya, Chong Yuan, Laurel L. Ballantyne, Hu Meng, William L. Smith, Garret A. FitzGerald, Colin D. Funk   +7 more
doaj   +1 more source

Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2017
Lysyl oxidase is able to remodel the extracellular matrix and its expression correlates with poor prognosis. Here the authors show that this protein modulates trapping of the epidermal growth factor receptor at the cell surface, causing persistent ...
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source

Disruption of the Schizosaccharomyces japonicus lig4 Disturbs Several Cellular Processes and Leads to a Pleiotropic Phenotype

Journal of Fungi, 2023
Gene targeting is a commonly used method to reveal the function of genes. Although it is an attractive tool for molecular studies, it can frequently be a challenge because its efficiency can be low and it requires the screening of a large number of ...
Lajos Acs-Szabo, Laszlo Attila Papp, Szonja Takacs, Ida Miklos   +3 more
doaj   +1 more source

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source

Production and characterization of eggs from hens with ovomucoid gene mutation

Poultry Science, 2021
Ovomucoid is a major egg white protein which is considered as the most dominant allergen in chicken eggs. Owing to the difficulty of separating ovomucoid from egg whites, researchers have adopted genetic deletion for development of hypoallergenic eggs ...
Takehiro Mukae, Kyoko Yoshii, Takuma Watanobe, Takahiro Tagami, Isao Oishi   +4 more
doaj   +1 more source

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

Viruses, 2018
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level.
Shuliang Chen, Xiao Yu, Deyin Guo
doaj   +1 more source

Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives

Frontiers in Oncology, 2023
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj   +1 more source

Targeting Epilepsy Genes [PDF]

Neuron, 1996
In medieval art it was traditional to show a demon emanating from a suffering epileptic at the conclusion of a seizure, with concern clearly evident regarding its inevitable reappearance. In this century, anticonvulsant drugs have been developed for their ability to control, rather than prevent or reverse, seizure disorders.
openaire   +2 more sources

Targeted insertion of large DNA sequences by homology‐directed repair or non‐homologous end joining in engineered tobacco BY‐2 cells using designed zinc finger nucleases

Plant Direct, 2019
Targeted integration of recombinant DNA fragments into plant genomes by DNA double‐strand break (DSB) repair mechanisms has become a powerful tool for precision engineering of crops.
Andreas Schiermeyer, Katja Schneider, Janina Kirchhoff, Thomas Schmelter, Natalie Koch, Ke Jiang, Denise Herwartz, Ryan Blue, Pradeep Marri, Pon Samuel, David R. Corbin, Steven R. Webb, Delkin O. Gonzalez, Otto Folkerts, Rainer Fischer, Helga Schinkel, W. Michael Ainley, Stefan Schillberg   +17 more
doaj   +1 more source