Results 21 to 30 of about 1,207,125 (312)

Disruption of the Schizosaccharomyces japonicus lig4 Disturbs Several Cellular Processes and Leads to a Pleiotropic Phenotype

Journal of Fungi, 2023
Gene targeting is a commonly used method to reveal the function of genes. Although it is an attractive tool for molecular studies, it can frequently be a challenge because its efficiency can be low and it requires the screening of a large number of ...
Lajos Acs-Szabo, Laszlo Attila Papp, Szonja Takacs, Ida Miklos   +3 more
doaj   +1 more source

Progress in the use of adeno-associated viral vectors for gene therapy [PDF]

, 2004
The development of safe and efficient gene transfer vectors is crucial for the success of gene therapy trials. A viral vector system promising to meet these requirements is based on the apathogenic adeno-associated virus (AAV-2), a member of the ...
Markus Braun-Falco, Hallek, M., Michael Hallek, Buning, H., Braun-Falco, M., Hildegard Büning   +5 more
core   +1 more source

Author Correction: Lysyl oxidase drives tumour progression by trapping EGF receptors at the cell surface

Nature Communications, 2019
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
HaoRan Tang, Leo Leung, Grazia Saturno, Amaya Viros, Duncan Smith, Gianpiero Di Leva, Eamonn Morrison, Dan Niculescu-Duvaz, Filipa Lopes, Louise Johnson, Nathalie Dhomen, Caroline Springer, Richard Marais   +12 more
doaj   +1 more source

Production and characterization of eggs from hens with ovomucoid gene mutation

Poultry Science, 2021
Ovomucoid is a major egg white protein which is considered as the most dominant allergen in chicken eggs. Owing to the difficulty of separating ovomucoid from egg whites, researchers have adopted genetic deletion for development of hypoallergenic eggs ...
Takehiro Mukae, Kyoko Yoshii, Takuma Watanobe, Takahiro Tagami, Isao Oishi   +4 more
doaj   +1 more source

Targeting Epilepsy Genes [PDF]

Neuron, 1996
In medieval art it was traditional to show a demon emanating from a suffering epileptic at the conclusion of a seizure, with concern clearly evident regarding its inevitable reappearance. In this century, anticonvulsant drugs have been developed for their ability to control, rather than prevent or reverse, seizure disorders.
openaire   +2 more sources

Control of Aflatoxin Production of Aspergillus flavus and Aspergillus parasiticus Using RNA Silencing Technology by Targeting aflD (nor-1) Gene. [PDF]

, 2011
Aspergillus flavus and Aspergillus parasiticus are important pathogens of cotton, corn, peanuts and other oil-seed crops, producing toxins both in the field and during storage.
Daniel Caley, Naresh Magan, Abdel-Hadi, A, Abdel-Hadi, Ahmed, Caley, D. P., Carter, D. R., Ahmed M. Abdel-Hadi, Ahmed Abdel-Hadi, David R. F. Carter, Caley, D, Carter, D, Daniel P. Caley, Magan, Naresh, David Carter, Magan, N   +14 more
core   +1 more source

CRISPR-Cas Targeting of Host Genes as an Antiviral Strategy

Viruses, 2018
Currently, a new gene editing tool—the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) associated (Cas) system—is becoming a promising approach for genetic manipulation at the genomic level.
Shuliang Chen, Xiao Yu, Deyin Guo
doaj   +1 more source

Targeting casein kinase 1 for cancer therapy: current strategies and future perspectives

Frontiers in Oncology, 2023
Casein Kinase 1 (CK1) is a family of serine/threonine protein kinases that play a crucial role in various cellular processes, including cell proliferation, survival, and metabolism.
Ngo Hoang Long, Sook-Jeong Lee
doaj   +1 more source

Group II Intron-Based Gene Targeting Reactions in Eukaryotes [PDF]

, 2008
Background: Mobile group II introns insert site-specifically into DNA target sites by a mechanism termed retrohoming in which the excised intron RNA reverse splices into a DNA strand and is reverse transcribed by the intron-encoded protein.
Mastroianni Marta, Jamie Vernon, Wallingford, John, Travis B White, White Travis B., Wallingford John, Alan M. Lambowitz, Matsuura, Manabu, Watanabe Kazuo, Matsuura Manabu, Watanabe, Kazuo, Mastroianni, Marta, Manabu Matsuura, Lambowitz Alan M., Zhuang Fanglei, Vernon, Jamie, John Wallingford, Lambowitz, Alan M., Fanglei Zhuang, Vernon Jamie, Zhuang, Fanglei, Alan M Lambowitz, White, Travis B., Kazuo Watanabe, Travis B. White, Marta Mastroianni   +25 more
core   +2 more sources

Targeted insertion of large DNA sequences by homology‐directed repair or non‐homologous end joining in engineered tobacco BY‐2 cells using designed zinc finger nucleases

Plant Direct, 2019
Targeted integration of recombinant DNA fragments into plant genomes by DNA double‐strand break (DSB) repair mechanisms has become a powerful tool for precision engineering of crops.
Andreas Schiermeyer, Katja Schneider, Janina Kirchhoff, Thomas Schmelter, Natalie Koch, Ke Jiang, Denise Herwartz, Ryan Blue, Pradeep Marri, Pon Samuel, David R. Corbin, Steven R. Webb, Delkin O. Gonzalez, Otto Folkerts, Rainer Fischer, Helga Schinkel, W. Michael Ainley, Stefan Schillberg   +17 more
doaj   +1 more source