Results 1 to 10 of about 708,746 (292)
RNA secondary structure prediction with pseudoknots: Contribution of algorithm versus energy model. [PDF]
PLoS ONE, 2018 RNA is a biopolymer with various applications inside the cell and in biotechnology. Structure of an RNA molecule mainly determines its function and is essential to guide nanostructure design.
Hosna Jabbari +2 more
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Talanta Open, 2023 The complexity of procedures, concentration dependency, and time consumption associated with traditional microRNA analysis platforms render them unsuitable for point-of-care (POC) diagnostics.
Zahra Sahafnejad +5 more
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Composing RNA Nanostructures from a Syntax of RNA Structural Modules [PDF]
Nano Letters, 2017 Natural stable RNAs fold and assemble into complex three-dimensional architectures by relying on the hierarchical formation of intricate, recurrent networks of noncovalent tertiary interactions. These sequence-dependent networks specify RNA structural modules enabling orientational and topological control of helical struts to form larger self-folding ...
Cody Geary +4 more
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RNA-Peptide Conjugation through an Efficient Covalent Bond Formation
Applied Sciences, 2020 Many methods for modification of an oligonucleotide with a peptide have been developed to apply for the therapeutic and diagnostic applications or for the assembly of nanostructure.
Shun Nakano +3 more
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Advanced Science, 2020 Glioma initiating cells (GICs) function as the seed for the propagation and relapse of glioma. Designing a smart and efficient strategy to target the GICs and to suppress the multiple signaling pathways associated with stemness and chemoresistance is ...
Gan Jiang +15 more
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Nanomaterials, 2021 A variety of nanostructured diagnostic tools have been developed for the precise detection of known genetic variants. Molecular beacon systems are very promising tools due to their specific selectivity coupled with relatively lower cost and time ...
Jeonghun Kim, So Yeon Ahn, Soong Ho Um
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Preparation of Chemically Modified RNA Origami Nanostructures [PDF]
Chemistry – A European Journal, 2014 AbstractIn nucleic acid nanotechnology, designed RNA molecules are widely explored because of their usability originating from RNA’s structural and functional diversity. Herein, a method to design and prepare RNA nanostructures by employing DNA origami strategy was developed.
Endo, Masayuki +4 more
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Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant
Pharmaceutics, 2019 Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene expression and pathways. Although some adjuvants have been approved for commercial use in human vaccines (e.g., Alum, MF59, and AS03), they might elicit adverse side ...
Hyeong-Jun Park +8 more
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DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy
Frontiers in Pharmacology, 2020 Immunotherapy has received increasing attention due to its low potential side effects and high specificity. For instance, cancer immunotherapy has achieved great success.
Qingjia Chi +5 more
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Assembly of RNA nanostructures on supported lipid bilayers [PDF]
Nanoscale, 2015 The assembly of nucleic acid nanostructures with controlled size and shape has large impact in the fields of nanotechnology, nanomedicine and synthetic biology.
Aleksandra P, Dabkowska +7 more
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