Artificial RNA Motifs Expand the Programmable Assembly between RNA Modules of a Bimolecular Ribozyme Leading to Application to RNA Nanostructure Design [PDF]
Biology, 2017 A bimolecular ribozyme consisting of a core ribozyme (ΔP5 RNA) and an activator module (P5abc RNA) has been used as a platform to design assembled RNA nanostructures.
Md. Motiar Rahman +2 more
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Development of Triangle RNA Nanostructure for Enhancing RNAi-Mediated Control of Botrytis cinerea Through Spray-Induced Gene Silencing Without Extra Nanocarrier [PDF]
BiologyBotrytis cinerea, a necrotrophic fungal pathogen responsible for gray mold, poses a severe threat to over 1400 plant species, causing significant pre- and postharvest losses worldwide.
Ya Chen +4 more
doaj +2 more sources
Development of an RNA Nanostructure for Effective Botrytis cinerea Control through Spray-Induced Gene Silencing without an Extra Nanocarrier [PDF]
Journal of FungiSpray-induced gene silencing represents an eco-friendly approach for crop protection through the use of double-stranded RNA (dsRNA) to activate the RNA interference (RNAi) pathway, thereby silencing crucial genes in pathogens.
Fangli Wu +4 more
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CHIMIA, 2018 Ribonuclease P (RNase P) is a class of enzymes involved in the processing of precursor tRNAs to remove their 5'-leader sequences. Ribonuclease P enzymes are classified into two completely distinct classes, i.e.
Yuri Nozawa +3 more
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ATP-fueled autonomous pathway-selective signal transduction on DNA-nanostructure tracks [PDF]
Nature CommunicationsChemically fueled non-equilibrium self-assemblies offer a promising route toward constructing artificial living systems, yet current strategies lack molecular-level control over where such artificial non-equilibrium assemblies occur.
Xingyu Liu, Yan Liu, Jie Deng
doaj +2 more sources
Base modifications shift tertiary structure and activity in synthetic RNA origami and a natural ribozyme [PDF]
Nature CommunicationsModified nucleotide bases like 5-methylcytosine (m5C) and N1-methyl-pseudouridine (m1Ψ) are widely used to enhance stability and reduce immunogenicity in therapeutic RNAs, yet their impact on RNA tertiary structure remains unclear.
Deepak Kumar Yadav +3 more
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Tetrahedral DNA dendritic nanostructure-enhanced FISH for high-speed, sensitive spatial transcriptomics [PDF]
Nature CommunicationsUnderstanding where genes are active within tissues is essential to explain how cells build and maintain organs, yet many spatial RNA assays are slow and weak, limiting short-transcript detection and masking cellular diversity.
Yi-Fan Wang +5 more
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A polyphenol-assisted IL-10 mRNA delivery system for ulcerative colitis
Acta Pharmaceutica Sinica B, 2022 With the development of synthesis technology, modified messenger RNA (mRNA) has emerged as a novel category of therapeutic agents for a broad of diseases.
Zhejie Chen +8 more
doaj +1 more source
Molecules, 2023 The multimolecular assembly of three-dimensionally structured proteins forms their quaternary structures, some of which have high geometric symmetry. The size and complexity of protein quaternary structures often increase in a hierarchical manner, with ...
Mst. Ayesha Siddika +6 more
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Catalytic RNA Oligomers Formed by Co-Oligomerization of a Pair of Bimolecular RNase P Ribozymes
Molecules, 2022 Naturally occurring ribozymes with a modular architecture are promising platforms for construction of RNA nanostructures because modular redesign enables their oligomerization.
Mst. Ayesha Siddika +7 more
doaj +1 more source