Results 41 to 50 of about 883,773 (191)

Detection of genome-scale ordered RNA structure (GORS) in genomes of positive-stranded RNA viruses:Implications for virus evolution and host persistence [PDF]

, 2004
Discrete RNA secondary and higher-order structures, typically local in extent, play a fundamental role in RNA virus replication. Using new bioinformatics analysis methods, we have identified genome-scale ordered RNA structure (GORS) in many genera and ...
Evans, David J, Simmonds, Peter, Tuplin, Andrew, Tuplin, A, Evans, DJ, Simmonds, P, Evans, DJ; id_orcid   +6 more
core   +1 more source

Structures of Artificially Designed RNA Nanoarchitectures at Near-Atomic Resolution [PDF]

, 2020
Though advances in nanotechnology have enabled the construction of synthetic nucleic acid based nanoarchitectures with ever-increasing complexity for various applications, high-resolution structures are lacking due to the difficulty of obtaining good ...
Yossi, Weizmann, Yaming, Shao, Joseph A., Piccirilli, Di, Liu   +3 more
core   +2 more sources

Nanostructured RNA for RNA Intereference

YAKUGAKU ZASSHI, 2013
RNA interference (RNAi) is a potent and highly specific gene-silencing phenomenon which is initiated or triggered by double-stranded RNAs (dsRNAs). Shortly after the development of RNAi, small interfering RNAs (siRNAs) that are 21 nucleotides in length with a 3' nucleotide overhang were shown to be very effective in mammalian cells.
openaire   +3 more sources

Formamide significantly enhances the efficiency of chemical adenylation of RNA sequencing ligation adaptors [PDF]

, 2023
Preadenylated single-stranded DNA ligation adaptors are essential reagents in many next generation RNA sequencing library preparation protocols. These oligonucleotides can be adenylated enzymatically or chemically.
Watts, Jonathan K, Hildebrand, Samuel R, Hedger, Adam K, Khvorova, Anastasia, Yamada, Ken   +4 more
core   +1 more source

A hepatitis C virus cis-acting replication element forms a long-range RNA-RNA interaction with upstream RNA sequences in NS5B [PDF]

, 2008
The genome of hepatitis C virus (HCV) contains cis-acting replication elements (CREs) comprised of RNA stem-loop structures located in both the 5' and 3' non-coding regions (NCR), and in the NS5B coding sequence.
Diviney, Sinéad, Elliot, R., Evans, David John, Evans, D., Armstrong, V, Tuplin, Andrew, Evans, D.J., Struthers, Madeleine, Struthers, M., Elliott, Richard M., Diviney, S., Tuplin, A., Armstrong, V., Struthers, M, Simmonds, Peter, Elliott, Richard Michael, Armstrong, Victoria, Tuplin, A, Evans, David J., Simmonds, P., Diviney, S, Elliott, R.M., Simmonds, P, Evans, David John; id_orcid   +23 more
core   +1 more source

Adjuvanted RNA Origami—A Tunable Peptide Assembly Platform for Constructing Cancer Nanovaccines

Vaccines
Background/Objectives: Cancer peptide vaccines represent a promising strategy to develop targeted and personalized treatments for cancer patients.
Theresa Yip, Xinyi Tu, Xiaodong Qi, Hao Yan, Yung Chang   +4 more
doaj   +1 more source

Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy

Bioactive Materials, 2022
CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool, that relies on Cas9 protein and single guided RNA (sgRNA) to edit target DNA.
Chunhui Li, Tongren Yang, Yuhua Weng, Mengjie Zhang, Deyao Zhao, Shuai Guo, Bo Hu, Wanxuan Shao, Xiaoxia Wang, Abid Hussain, Xing-Jie Liang, Yuanyu Huang   +11 more
doaj   +1 more source

RNA Nanoparticle for Treatment of Gastric Cancer [PDF]

, 2020
The presently-disclosed subject matter relates to RNA-based composition and method to treat gastric cancer in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure and composition containing a multiple ...
Shu, Dan, Shu, Yi, Cui, Daxiang, Zhang, Chunlei, Guo, Peixuan   +4 more
core   +1 more source

Co-Delivery of mRNA and pDNA Using Thermally Stabilized Coacervate-Based Core-Shell Nanosystems

Pharmaceutics, 2021
Co-delivery of different species of protein-encoding polynucleotides, e.g., messenger RNA (mRNA) and plasmid DNA (pDNA), using the same nanocarrier is an interesting topic that remains scarcely researched in the field of nucleic acid delivery.
Sarah S. Nasr, Sangeun Lee, Durairaj Thiyagarajan, Annette Boese, Brigitta Loretz, Claus-Michael Lehr   +5 more
doaj   +1 more source

Hybrid DNA/RNA nanostructures with 2′-5′ linkages [PDF]

Nanoscale, 2020
We report here the first instance of nucleic acid nanostructures that contain 2′-5′ linkages and characterize structures of different complexities: a simple duplex to a 4-arm junction, a double crossover (DX) motif and a tensegrity triangle motif.
Arun Richard Chandrasekaran, Johnsi Mathivanan, Parisa Ebrahimi, Javier Vilcapoma, Alan A. Chen, Ken Halvorsen, Jia Sheng   +6 more
openaire   +2 more sources