Results 61 to 70 of about 883,773 (191)

Engineering Fe/Mn-doped zinc oxide nanosonosensitizers for ultrasound-activated and multiple ferroptosis-augmented nanodynamic tumor suppression

Materials Today Bio, 2022
As an effective tumor-therapeutic modality, ultrasound-triggered sonodynamic therapy (SDT) has been extensively explored to induce cancer cell death by activating sonosensitizers to generate reactive oxygen species (ROS).
Zhongqian Hu, Xinran Song, Li Ding, Yu Cai, Luodan Yu, Lijuan Zhang, Yajun Zhou, Yu Chen   +7 more
doaj   +1 more source

DNA-based nanostructures for RNA delivery

Medical Review
Abstract RNA-based therapeutics have emerged as a promising approach for the treatment of various diseases, including cancer, genetic disorders, and infectious diseases. However, the delivery of RNA molecules into target cells has been a major challenge due to their susceptibility to degradation and inefficient cellular uptake.
Yuanyuan Wu, Liangzhi Luo, Ziyang Hao, Dongsheng Liu   +3 more
openaire   +3 more sources

Development of Non-Viral, Trophoblast-Specific Gene Delivery for Placental Therapy. [PDF]

PLoS ONE, 2015
Low birth weight is associated with both short term problems and the fetal programming of adult onset diseases, including an increased risk of obesity, diabetes and cardiovascular disease.
Noura Abd Ellah, Leeanne Taylor, Weston Troja, Kathryn Owens, Neil Ayres, Giovanni Pauletti, Helen Jones   +6 more
doaj   +1 more source

Identification of novel components of Trypanosoma brucei editosomes [PDF]

, 2003
The editosome is a multiprotein complex that catalyzes the insertion and deletion of uridylates that occurs during RNA editing in trypanosomatids. We report the identification of nine novel editosome proteins in Trypanosoma brucei.
Schnaufer, Achim; id_orcid, Wang, Bingbing, Salavati, Reza, Stuart, Kenneth, Carmean, Nicole, Panigrahi, Aswini K, Ernst, Nancy L   +6 more
core   +1 more source

Equine Adipose-Derived Mesenchymal Stromal Cells Release Extracellular Vesicles Enclosing Different Subsets of Small RNAs

Stem Cells International, 2019
Background. Equine adipose-derived mesenchymal stromal cells (e-AdMSC) exhibit attractive proregenerative properties strongly related to the delivery of extracellular vesicles (EVs) that enclose different kinds of molecules including RNAs. In this study,
Stefano Capomaccio, Katia Cappelli, Cinzia Bazzucchi, Mauro Coletti, Rodolfo Gialletti, Franco Moriconi, Fabrizio Passamonti, Marco Pepe, Stefano Petrini, Samanta Mecocci, Maurizio Silvestrelli, Luisa Pascucci   +11 more
doaj   +1 more source

Molecular mechanism of the RNA helicase DHX37 and its activation by UTP14A in ribosome biogenesis [PDF]

, 2019
Eukaryotic ribosome biogenesis is a highly orchestrated process involving numerous assembly factors including ATP-dependent RNA helicases. The DEAH helicase DHX37 (Dhr1 in yeast) is activated by the ribosome biogenesis factor UTP14A to facilitate ...
van den Heuvel, Jasmin, Jinek, Martin; https://orcid.org/, Boneberg, Franziska M, Kutay, Ulrike; https://orcid.org/, Kobel, Lena, Bammert, Lukas, Bargsten, Katja, Brandmann, Tobias, Kobel L, Boneberg, Franziska M., Kutay, Ulrike, van den Heuvel J, Kutay, Ulrike (author), Bargsten K, van den Heuvel, Jasmin (author), Jinek, Martin, Bammert, Lukas (author), Bargsten, Katja (author), Brandmann, Tobias (author), Boneberg, Franziska M. (author), Jinek, Martin (author), Boneberg FM, Jinek M, Bammert L, Kobel, Lena (author), Brandmann T, Kutay U   +26 more
core   +1 more source

Turing miRNA into infinite coordination supermolecule: a general and enabling nanoengineering strategy for resurrecting nuclear acid therapeutics

Journal of Nanobiotechnology, 2022
Background Clinical translation of therapeutic nuclear acid, particularly those targeting tumor progression, has been hampered by the intrinsic weaknesses of nuclear acid therapeutic including poor systemic stability, rapid clearance, low membrane ...
Liya Li, Wangxiao He, Weiming You, Jin Yan, Wenjia Liu   +4 more
doaj   +1 more source

Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs [PDF]

, 2010
Theis C, Janssen S, Giegerich R. Prediction of RNA Secondary Structure Including Kissing Hairpin Motifs. In: Moulton V, Singh M, eds. Algorithms in Bioinformatics. 10th international workshop (WABI 2010), proceedings. Lecture Notes in Bioinformatics. Vol
Corinna Theis, Theis, Corinna, Moulton, Vincent, Singh, Mona, Stefan Janssen, Janssen, Stefan ; https://orcid.org/, Robert Giegerich, Giegerich, Robert   +7 more
core   +1 more source

Single-molecule observations of RNA–RNA kissing interactions in a DNA nanostructure

Biomaterials Science, 2016
Unique complex formation of RNA molecules through specific hairpin loop interaction was visualized in a DNA origami.
Takeuchi, Yosuke, Endo, Masayuki, Suzuki, Yuki, Hidaka, Kumi, Durand, Guillaume, Dausse, Eric, Toulmé, Jean Jacques, Sugiyama, Hiroshi   +7 more
openaire   +3 more sources

A splicing-dependent transcriptional checkpoint associated with prespliceosome formation [PDF]

, 2014
There is good evidence for functional interactions between splicing and transcription in eukaryotes, but how and why these processes are coupled remain unknown.
Chathoth, Keerthi T, Webb, Shaun, Barrass, J David, Beggs, Jean D   +3 more
core   +1 more source