Self-Assembled DNA Nanostructure as a Carrier for Targeted siRNA Delivery in Glioma Cells
International Journal of Nanomedicine, 2021 Yanghao Zhou,1 Qiang Yang,1 Feng Wang,1 Zunjie Zhou,1 Jing Xu,1 Si Cheng,2 Yuan Cheng1 1Department of Neurosurgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, People’s Republic of China; 2Department of ...
Zhou Y +6 more
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Complete probabilistic analysis of RNA shapes [PDF]
, 2006 Voß B, Giegerich R, Rehmsmeier M. Complete probabilistic analysis of RNA shapes. BMC Biology. 2006;4(1): 5.Background: Soon after the first algorithms for RNA folding became available, it was recognised that the prediction of only one energetically ...
Marc Rehmsmeier +8 more
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Designer RNA nanostructures co-transcribed and self-assembled inside human cell nuclei
Nature CommunicationsThe use of nucleic acid-based nanostructures as synthetic biological tools to interface with and regulate cell processes remains challenging. A major obstacle lies in nuclear delivery and retention within live eukaryotic cells.
Xu Chang +6 more
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Therapeutic applications of RNA nanostructures
RSC AdvancesNon-immunogenic RNA nanostructures are functionalized for/with RNAi, mRNA, ribozymes, CRISPR, and small molecule drugs. Immunogenic RNA nanostructures are designed as immunostimulants and cancer vaccine platforms. Created in Biorender.com.
Theresa Yip +3 more
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Diverging affinity of tospovirus RNA silencing suppressor proteins, NSs, for various RNA duplex molecules [PDF]
, 2010 The tospovirus NSs protein was previously shown to suppress the antiviral RNA silencing mechanism in plants. Here the biochemical analysis of NSs proteins from different tospoviruses, using purified NSs or NSs containing cell extracts, is described.
Kormelink, R.J.M. +16 more
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Coarse-graining RNA nanostructures for molecular dynamics simulations [PDF]
Physical Biology, 2010 A series of coarse-grained models have been developed for the study of the molecular dynamics of RNA nanostructures. The models in the series have one to three beads per nucleotide and include different amounts of detailed structural information.
Paliy, M., Melnik, R., Shapiro, B.A.
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Programmable RNA Nanostructures Enable Nanopore Detection of Cotranscriptionally Introduced RNA Modifications. [PDF]
Nano LettTracking RNA synthesis and metabolic histories requires co-transcriptional incorporation of modified nucleotides. However, identifying the incorporation of modified nucleotides in nascent RNA remains challenging, particularly for short RNAs. Here, we developed a method utilizing solid-state nanopores and DNA:RNA nanostructures to detect modified ...
Mohora I +5 more
europepmc +3 more sources
Domain orientation in the RNA helicase YxiN and the role of conformational changes for RNA unwinding [PDF]
, 2010 The RNA helicase YxiN from Bacillus subtilis is a member of the family of DEAD box proteins. YxiN is able to unwind RNA double strands in an ATP-dependent manner. The ability to catalyse RNA rearrangement is in vivo presumably necessary for the bacterial
Karow, Anne R.
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The mutual interaction of glycolytic enzymes and RNA in post-transcriptional regulation
, 2022 Wegener M, Dietz K-J. The mutual interaction of glycolytic enzymes and RNA in post-transcriptional regulation. RNA . 2022.About three decades ago, researchers suggested that metabolic enzymes participate in cellular processes that are unrelated to their ...
Dietz, Karl-Josef +3 more
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RNA-Based Compositions and Adjuvants for Prophylactic and Therapeutic Treatment [PDF]
, 2019 The present invention is directed towards an artificial RNA nano structure comprising multiple external strands of RNA, each external strand comprising about 40-50 nucleotides; one internal strand of RNA comprising more than about 50 nucleotides; the ...
Jasinski, Daniel L. +3 more
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