Results 31 to 40 of about 883,773 (191)
Advanced Science, 2020 Glioma initiating cells (GICs) function as the seed for the propagation and relapse of glioma. Designing a smart and efficient strategy to target the GICs and to suppress the multiple signaling pathways associated with stemness and chemoresistance is ...
Gan Jiang +15 more
doaj +1 more source
Comprehensive Analysis of the Safety Profile of a Single-Stranded RNA Nano-Structure Adjuvant
Pharmaceutics, 2019 Adjuvants enhance the efficacy of vaccines by stimulating immune response-related gene expression and pathways. Although some adjuvants have been approved for commercial use in human vaccines (e.g., Alum, MF59, and AS03), they might elicit adverse side ...
Hyeong-Jun Park +8 more
doaj +1 more source
Crystal structure of Schmallenberg orthobunyavirus nucleoprotein-RNA complex reveals a novel RNA sequestration mechanism [PDF]
, 2013 Schmallenberg virus (SBV) is a newly emerged orthobunyavirus (family Bunyaviridae) that has caused severe disease in the offspring of farm animals across Europe.
Richard M. Elliott +16 more
core +1 more source
Nanomaterials, 2021 A variety of nanostructured diagnostic tools have been developed for the precise detection of known genetic variants. Molecular beacon systems are very promising tools due to their specific selectivity coupled with relatively lower cost and time ...
Jeonghun Kim, So Yeon Ahn, Soong Ho Um
doaj +1 more source
, 2021 Robust methods are critical for testing the in vivo regulatory mechanism of RNA binding proteins. Here we report improvement of a protein–mRNA tethering assay to probe the function of an RNA binding protein in its natural context within the C.
Kimble, Judith +7 more
core +1 more source
RNA Nanoparticles for Brain Tumor Treatment [PDF]
, 2020 The presently-disclosed subject matter relates to an artificial RNA nanostructure molecule and method to treat brain tumor in a subject. More particularly, the presently disclosed subject matter relates to a RNA nanostructure containing a multiple ...
Croce, Carlo M. +4 more
core +1 more source
Preparation of Chemically Modified RNA Origami Nanostructures [PDF]
Chemistry – A European Journal, 2014 AbstractIn nucleic acid nanotechnology, designed RNA molecules are widely explored because of their usability originating from RNA’s structural and functional diversity. Herein, a method to design and prepare RNA nanostructures by employing DNA origami strategy was developed.
Endo, Masayuki +4 more
openaire +2 more sources
DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy
Frontiers in Pharmacology, 2020 Immunotherapy has received increasing attention due to its low potential side effects and high specificity. For instance, cancer immunotherapy has achieved great success.
Qingjia Chi +5 more
doaj +1 more source
Trim25 is an RNA-specific activator of Lin28a/TuT4-mediated uridylation [PDF]
, 2014 RNA binding proteins have thousands of cellular RNA targets and often exhibit opposite or passive molecular functions. Lin28a is a conserved RNA binding protein involved in pluripotency and tumorigenesis that was previously shown to trigger TuT4-mediated
Roy Choudhury, Nila +11 more
core +1 more source
Assembly of RNA nanostructures on supported lipid bilayers [PDF]
Nanoscale, 2015 The assembly of nucleic acid nanostructures with controlled size and shape has large impact in the fields of nanotechnology, nanomedicine and synthetic biology.
Aleksandra P, Dabkowska +7 more
openaire +2 more sources