Results 31 to 40 of about 16,956 (222)

Inhibition of telomerase activity by HDV ribozyme in cancers

Journal of Experimental & Clinical Cancer Research, 2011
Background Telomerase plays an important role in cell proliferation and carcinogenesis and is believed to be a good target for anti-cancer drugs. Elimination of template function of telomerase RNA may repress the telomerase activity.
Gao Yanjing, Jin Dachuan, Gu Junchao, Lu Yingying, Yuan Mengbiao   +4 more
doaj   +1 more source

Toward Multi(radio)metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates

Angewandte Chemie, Volume 138, Issue 27, 1 July 2026.
This work presents the first enzymatic polymerization of defined metal‐chelator‐modified nucleotides that leverage polymerase fidelity for uniform (radio)metal loading with successful incorporation of five different metals: Ga, In, Tb, Lu, and Y.
Antonio A. W. L. Wong, François Bénard, David M. Perrin   +2 more
wiley   +2 more sources

The Hammerhead Ribozyme: A Long History for a Short RNA

Molecules, 2017
Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner.
Marcos de la Peña, Inmaculada García-Robles, Amelia Cervera   +2 more
doaj   +1 more source

Ribozyme activity modulates the physical properties of RNA–peptide coacervates

eLife, 2023
Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay, Elia Salibi, Basusree Ghosh, TY Dora Tang, Hannes Mutschler   +4 more
doaj   +1 more source

Trans-splicing with the group I intron ribozyme from Azoarcus [PDF]

, 2014
Group I introns are ribozymes (catalytic RNAs) that excise themselves from RNA primary transcripts by catalyzing two successive transesterification reactions.
Dolan, Gregory F, Müller, Ulrich F
core   +1 more source

Identification of selective hepatitis delta virus ribozyme inhibitors by high-throughput screening of small molecule libraries

JHEP Reports, 2023
Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka, Stéphanie Conzelmann, Yves Cambet, Tifany Schaer, Francesco Negro, Sophie Clément   +5 more
doaj   +1 more source

Ribozyme-Mediated Cleavage of a Substrate Analogue Containing an Internucleotide-Bridging 5‘-Phosphorothioate:  Evidence for the Single-Metal Model^†

, 2016
An oligonucleotide substrate containing a 5‘-bridging phosphorothioate linkage adjacent to a ribonucleotide has been used to investigate the cleavage mechanism of the hammerhead ribozyme and to probe the catalytic role of the metal cofactor(s ...
Robert G. Kuimelis (2948322), Larry W. McLaughlin (10778)   +1 more
core   +1 more source

Factorization Machine with Iterative Quantum Reverse Annealing: A Python Package for Batch Black‐Box Optimization With Reverse Quantum Annealing

Advanced Intelligent Discovery, EarlyView.
Factorization machine with iterative quantum reverse annealing (FMIRA) leverages quantum reverse annealing to perform batch black‐box optimization. Factorization machine with quantum annealing (FMQA) is a widely used python package for solving black‐box optimization problems using D‐Wave quantum annealers.
Andrejs Tučs, Ryo Tamura, Koji Tsuda
wiley   +1 more source

RATEX: A Scalable RNA‐Based Platform for Logical and Multi‐Layered Cellular Programming

Angewandte Chemie, Volume 138, Issue 26, 22 June 2026.
RATEX integrated ribosome‐mediated transcription control with synthetic RNA regulators, enabling simultaneous processing of RNA, metabolite, and small‐molecule inputs through complex logic operations within a single transcript. The platform achieves up to 1,492‐fold gene regulation, multi‐input hybrid logic gates, RNA‐programmed signaling cascades, and
Hyunseop Goh, Hansol Kang, Chaeri Kim, Jongmin Kim   +3 more
wiley   +2 more sources

An RNA Triangle with Six Ribozyme Units Can Promote a Trans-Splicing Reaction through Trimerization of Unit Ribozyme Dimers

Applied Sciences, 2021
Ribozymes are catalytic RNAs that are attractive platforms for the construction of nanoscale objects with biological functions. We designed a dimeric form of the Tetrahymena group I ribozyme as a unit structure in which two ribozymes were connected in a ...
Junya Akagi, Takahiro Yamada, Kumi Hidaka, Yoshihiko Fujita, Hirohide Saito, Hiroshi Sugiyama, Masayuki Endo, Shigeyoshi Matsumura, Yoshiya Ikawa   +8 more
doaj   +1 more source