Results 31 to 40 of about 5,544 (121)
Investigation of the role of LRP in multidrug resistance [PDF]
, 1998 There have been many reports linking the overexpression of the lung resistance-related protein (LRP) with cross-resistance to chemotherapeutic drugs.
Byrne, Daragh
core +2 more sources
Long Noncoding RNAs in Aortic Dissection: Mechanistic Roles and Therapeutic Potential
AGING MEDICINE, EarlyView.Aortic dissection (AD) involves vascular inflammation, VSMC dysfunction, and ECM degradation. LncRNAs regulate AD progression via ceRNA networks, with great potential as diagnostic biomarkers and therapeutic targets, while further clinical validation is needed.
Chao Chang +5 more
wiley +1 more source
Advanced Intelligent Discovery, EarlyView.Factorization machine with iterative quantum reverse annealing (FMIRA) leverages quantum reverse annealing to perform batch black‐box optimization. Factorization machine with quantum annealing (FMQA) is a widely used python package for solving black‐box optimization problems using D‐Wave quantum annealers.
Andrejs Tučs, Ryo Tamura, Koji Tsuda
wiley +1 more source
In vitro Evolution and Engineering for Improved Ribozyme Polymerase Production [PDF]
, 2011 According to the "RNA World Hypothesis" the first self replicating molecule formed from the prebiotic chemicals is the ribozyme. A model compartmentalized self replicating system for ribozyme polymerases is designed and used to improve activity,
Muhammad Waheed Akktar +2 more
core
Hairpin Ribozyme Structure and Dynamics
, 1997 A wide range of experimental methods have been used to explore the structure and function of the hairpin ribozyme. In vitro selection methods has provided comprehensive information on RNA secondary structure and the identity of essential bases within the
Banerjee, Aloke Raj +17 more
core +1 more source
Trans-splicing with the group I intron ribozyme from Azoarcus [PDF]
, 2014 Group I introns are ribozymes (catalytic RNAs) that excise themselves from RNA primary transcripts by catalyzing two successive transesterification reactions.
Dolan, Gregory F, Müller, Ulrich F
core +1 more source
Time-resolved and static NMR characterization of the structure and folding kinetics of the Diels-Alder ribozyme [PDF]
, 2009 Despite the well-known importance of ribonucleic acids (RNA) in cell biology, it is astounding to realize the pace at which new fundamental functions of RNAs have been discovered.
Manoharan, Vijayalaxmi
core
Nucleobase Participation in Ribozyme Catalysis
, 2016 We constructed a modified form of the VS ribozyme containing an imidazole ring in place of adenine at position 756. The novel ribozyme is active in both cleavage and ligation reactions. The reaction is efficient, although relatively slow. The results are
Zheng-yun Zhao (587046) +6 more
core +1 more source
Applied Sciences, 2021 Ribozymes are catalytic RNAs that are attractive platforms for the construction of nanoscale objects with biological functions. We designed a dimeric form of the Tetrahymena group I ribozyme as a unit structure in which two ribozymes were connected in a ...
Junya Akagi +8 more
doaj +1 more source
Molecular studies on plant glycerol-s-phosphate acyltransferases [PDF]
, 2000 The main objective of this research is to advance our understanding of the biochemical properties and the structure-function relationships of the chloroplast glycerol-3-phosphate acyltransferases in plants.
Kroon, Johannes Theodorus Maria
core