Results 21 to 30 of about 5,544 (121)
Arginine cofactors on the polymerase ribozyme. [PDF]
PLoS ONE, 2011 The RNA world hypothesis states that the early evolution of life went through a stage in which RNA served both as genome and as catalyst. The central catalyst in an RNA world organism would have been a ribozyme that catalyzed RNA polymerization to ...
Chengguo Yao +4 more
doaj +1 more source
Structure-based insights into self-cleavage by a four-way junctional twister-sister ribozyme
Nature Communications, 2017 Twister-sister is a self-cleaving ribozyme. Here, the authors report the 2.0 Å crystal structure of the four-way junctional twister-sister ribozyme in the pre-catalytic state and discuss mechanistic implications based on their mutagenesis experiments and
Luqian Zheng +7 more
doaj +1 more source
The Kiss Switch Brings Inactive R3C Ligase Ribozyme Back to Life
Biology, 2018 R3C ligase ribozyme catalyzes the nucleophilic attack by a 3′-hydroxyl on a 5′-α-phosphorus of triphosphates to form a 3′-5′-phosphodiester bond. In the present study, although the truncation of R3C ribozyme was accompanied by a large reduction in ...
Kana Tanizawa +4 more
doaj +1 more source
Inhibition of telomerase activity by HDV ribozyme in cancers
Journal of Experimental & Clinical Cancer Research, 2011 Background Telomerase plays an important role in cell proliferation and carcinogenesis and is believed to be a good target for anti-cancer drugs. Elimination of template function of telomerase RNA may repress the telomerase activity.
Gao Yanjing +4 more
doaj +1 more source
Intracellular Immunization against SIVmacUtilizing a Hairpin Ribozyme [PDF]
, 1996 A hairpin ribozyme targeting the 3′ LTR region (9456) of SIVmac239was cloned into a murine retroviral vector. This target sequence is conserved among various SIV, as well as most HIV-2, strains.
WONG-STAAL, FLOSSIE +3 more
core +1 more source
, 2021 The lariat capping ribozyme (LCrz) constitutes an independent class of ribozymes. It is the defining feature of twin-ribozyme group I introns found in eukaryotic microorganisms.
Steinar Daae Johansen +8 more
core +1 more source
Ribozyme activity modulates the physical properties of RNA–peptide coacervates
eLife, 2023 Condensed coacervate phases are now understood to be important features of modern cell biology, as well as valuable protocellular models in origin-of-life studies and synthetic biology.
Kristian Kyle Le Vay +4 more
doaj +1 more source
The Hammerhead Ribozyme: A Long History for a Short RNA
Molecules, 2017 Small nucleolytic ribozymes are a family of naturally occurring RNA motifs that catalyse a self-transesterification reaction in a highly sequence-specific manner.
Marcos de la Peña +2 more
doaj +1 more source
JHEP Reports, 2023 Background & Aims: Chronic hepatitis delta is the most severe form of chronic viral hepatitis and is associated with faster progression towards cirrhosis, liver decompensation, and hepatocellular carcinoma.
Eirini D. Tseligka +5 more
doaj +1 more source
, 2016 An oligonucleotide substrate containing a 5‘-bridging phosphorothioate linkage adjacent to a ribonucleotide has been used to investigate the cleavage mechanism of the hammerhead ribozyme and to probe the catalytic role of the metal cofactor(s ...
Robert G. Kuimelis (2948322) +1 more
core +1 more source