Results 1 to 10 of about 50 (50)
RNA-based therapeutics to treat human fungal infections [PDF]
Trends in Microbiology, 2022 In recent decades, RNA-based therapeutics have transitioned from a near impossibility to a compelling treatment alternative for genetic disorders and infectious diseases. The mRNA vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are truly groundbreaking, and new adaptations are already being proposed to fight other microbes.
Alexander Bruch +2 more
openaire +3 more sources
The RNA world of fungal pathogens
PLOS Pathogens, 2023 Jürgen Manchot Stiftung http://dx.doi.org/10.13039 ...
Sankaranarayanan, Srimeenakshi +4 more
openaire +4 more sources
A fungal Argonaute interferes with RNA interference [PDF]
Nucleic Acids Research, 2018 Small RNA (sRNA)-mediated gene silencing phenomena, exemplified by RNA interference (RNAi), require a unique class of proteins called Argonautes (AGOs). An AGO protein typically forms a protein-sRNA complex that contributes to gene silencing using the loaded sRNA as a specificity determinant. Here, we show that MoAGO2, one of the three AGO genes in the
Nguyen, Quyet +8 more
openaire +6 more sources
RNA-Based Control of Fungal Pathogens in Plants
International Journal of Molecular Sciences, 2023 Our duty to conserve global natural ecosystems is increasingly in conflict with our need to feed an expanding population. The use of conventional pesticides not only damages the environment and vulnerable biodiversity but can also still fail to prevent crop losses of 20–40% due to pests and pathogens.
Christopher W. G. Mann +5 more
openaire +2 more sources
Extracellular vesicle-mediated export of fungal RNA [PDF]
Scientific Reports, 2015 Extracellular vesicles (EVs) play an important role in the biology of various organisms, including fungi, in which they are required for the trafficking of molecules across the cell wall. Fungal EVs contain a complex combination of macromolecules, including proteins, lipids and glycans.
Samuel Goldenberg +9 more
openaire +3 more sources
Fungal RNA editing: who, when, and why? [PDF]
Applied Microbiology and Biotechnology, 2020 Abstract RNA editing occurs in all kingdoms of life and in various RNA species. The editing of nuclear protein-coding transcripts has long been known in metazoans, but was only recently detected in fungi. In contrast to many metazoan species, fungal editing sites occur mostly in coding regions, and therefore, fungal editing can change protein ...
openaire +4 more sources
The common ancestral core of vertebrate and fungal telomerase RNAs [PDF]
Nucleic Acids Research, 2012 Telomerase is a ribonucleoprotein with an intrinsic telomerase RNA (TER) component. Within yeasts, TER is remarkably large and presents little similarity in secondary structure to vertebrate or ciliate TERs. To better understand the evolution of fungal telomerase, we identified 74 TERs from Pezizomycotina and Taphrinomycotina subphyla, sister clades to
Steve Hoffmann +9 more
openaire +3 more sources
FairBase: a comprehensive database of fungal A-to-I RNA editing [PDF]
Database, 2019 Frequent A-to-I RNA editing has recently been identified in fungi despite the absence of recognizable homologues of metazoan ADARs ("Adenosine Deaminases Acting on RNA"). In particular, there is emerging evidence showing that A-to-I editing is involved in sexual reproduction of filamentous fungi. Here, we report on the creation of FairBase - a fungal A-
Shuiqing Huang +7 more
openaire +3 more sources
RNA Biology in Fungal Phytopathogens
PLoS Pathogens, 2013 RNA-dependent processes are essential to determine when, where, and how much of a protein is synthesized. In eukaryotes, these processes start with transcription in the nucleus and end with mRNA translation at distinct cytoplasmic sites followed by mRNA degradation [1].
Carl Haag +2 more
openaire +5 more sources
Journal of Fungi, 2022 Fungal plant pathogens use proteinaceous effectors as well as newly identified secondary metabolites (SMs) and small non-coding RNA (sRNA) effectors to manipulate the host plant’s defense system via diverse plant cell compartments, distinct organelles, and many host genes.
Johannes Mapuranga +4 more
openaire +3 more sources