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Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

SUMOylation of UBE2C facilitates hepatocellular carcinoma proliferation and invasion via the MAPK pathway. [PDF]

Transl Cancer Res
Kang Y, Wang J, Li Y, Yang J.
europepmc   +1 more source

TDP-43 is coming to the cottage: A new tool to study neurodegenerative diseases. [PDF]

PLoS Biol
Rayner SL, Gitler AD.
europepmc   +1 more source

Systemic mRNA vaccines elicit rapid immune activation in canine brain tumors. [PDF]

J Immunother Cancer
Carrera-Justiz S, Aghaee M, Qdaisat S, Weidert F, Garcia GA, Fagman L, Zhang D, Stover B, Moor RSF, Xie C, Goldenberg E, von Roemeling C, Doonan B, Chardon-Robles J, Elliott L, Sawyer WG, Deleyrolle LP, Sahay B, Foster TP, Seligson ND, Rahman M, Ghiaseddin A, Castillo P, Lee JH, Silver NL, Doty A, Ligon JA, Milner RJ, Mitchell D, Mendez-Gomez H, Moore H, Sayour EJ.   +31 more
europepmc   +1 more source

A DNA-Based Binding Assay for the m⁶A-RNA Reader Proteins. [PDF]

Chembiochem
Bedi RK, Caflisch A.
europepmc   +1 more source

Transient mRNA-based CD117 CAR T cells effectively target acute myeloid leukemia <i>in vitro</i> for potential use as a preconditioning strategy. [PDF]

Immunooncol Technol
Inthanachai T, Sittplangkoon C, Tashiro H, Yagyu S, Palaga T, Tawinwung S, Suppipat K.   +6 more
europepmc   +1 more source

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Messenger RNA Decay

EcoSal Plus, 2007
This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved in mRNA decay; posttranscriptional ...
openaire   +2 more sources

Hormone inducible messenger RNA

Life Sciences, 1975
Abstract Steroid hormones regulate the synthesis of specific proteins in target tissue by controlling the synthesis of the corresponding messenger RNA's. In the chick oviduct, estrogen and progesterone induce the synthesis and accumulation of the specific messenger RNA's for the hormone-induced egg-white proteins, ovalbumin and avidin, respectively ...
S L, Woo, B W, O'Malley
openaire   +2 more sources