Results 241 to 250 of about 1,540,463 (333)

Development and Recent Advances in SLIPT‐PM: A Chemogenetic Platform for Manipulating Signaling at the Plasma Membrane

ChemBioChem, EarlyView.
SLIPT‐PM enables the translocation of tag‐fused proteins from the cytoplasm to the plasma membrane using a synthetic self‐localizing ligand. This user‐friendly system permits reversible control of diverse signaling pathways. This concept article highlights the key features and current applications of SLIPT‐PM as a powerful tool in chemical and ...
Shuya Ohira, Akinobu Nakamura, Kenta Terai, Shinya Tsukiji   +3 more
wiley   +1 more source

Docking and Molecular Dynamics Simulation‐Based Analysis of Advanced Small‐Molecule Kinase Inhibitors Identified pre‐let‐7 miRNA Binders

ChemBioChem, EarlyView.
An integrated computational approach evaluating the binding between pre‐let‐7 microRNA and small‐molecule kinase inhibitors (SMKIs) revealed varied pre‐let‐7 binding affinities among the advanced SMKIs. The results justified the characterization of potential RNA targets for kinase inhibitors and small molecules with protein targets in general.
Soma Roy, Yang Liu, Peng Wu
wiley   +1 more source

GABRINOX-2 protocol: a French, prospective, multicentre, randomised phase II trial evaluating gemcitabine/nab-paclitaxel followed by FOLFIRINOX versus FOLFIRINOX alone as first-line treatment for metastatic pancreatic cancer. [PDF]

BMJ Open
Portales F, Gourgou S, Fiess C, Salasc F, Assenat E, Ychou M.   +5 more
europepmc   +1 more source

Investigating the Interaction Profile of Unconjugated Ubiquitin: Chemical Biology and Affinity Enrichment Mass Spectrometric Approaches

ChemBioChem, EarlyView.
This mini review provides insights into the synergistic power of chemical biology techniques for generating defined ubiquitin (Ub) variants and the use of affinity enrichment mass spectrometry to decipher the Ub code. It focuses on unconjugated Ub variants, which have emerged as additional signaling molecules in the Ub lexicon. Furthermore, it outlines
Simon Maria Kienle, Katrin Stuber
wiley   +1 more source

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

EnsembleDesign: messenger RNA design minimizing ensemble free energy via probabilistic lattice parsing. [PDF]

Bioinformatics
Dai N, Zhou T, Tang WY, Mathews DH, Huang L.   +4 more
europepmc   +1 more source

Advancing Predictions of Oral Drug Absorption, CYP3A4 Induction, and Transporter‐Mediated Interactions Using a Human Primary Intestinal 3D Model (EpiIntestinal™)

Clinical Pharmacology &Therapeutics, EarlyView.
Accurate prediction of oral drug absorption in humans is essential for early drug development; however, physiologically relevant human models are lacking. This study aims to comprehensively assess the EpiIntestinal™, a human primary intestinal 3D model, for its ability to predict oral absorption (Fa), intestinal availability (Fg), CYP3A4 induction, and
Paresh P. Chothe, Andrea Whitcher‐Johnstone, Aniruddha Karve, Diane Ramsden, Niresh Hariparsad   +4 more
wiley   +1 more source

Effects of Modified Messenger RNA of Adiponectin Delivered by Lipid Nanoparticles on Adipogenesis and Bone Metabolism In Vitro and In Vivo. [PDF]

Cells
Xie Y, Ma Q, Wang J, Zhu ZX, El-Araby RE, Tu M, Li Z, Xu X, Tu Q, Chen J.   +9 more
europepmc   +1 more source

Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real‐World Data Utilization

Clinical Pharmacology &Therapeutics, EarlyView.
Clinical trials with pragmatic elements can capture diverse patient populations, enable efficient follow‐up, and reflect routine clinical practices; yet there is limited understanding of their design features, characteristics, and use of real‐world data (RWD). Based on a targeted search of PubMed/EMBASE (Jan‐2016 to Jul‐2024), a review was conducted to
Le Su, Lei Chen, Seema Betigeri, Nancy Dreyer, Helga Gardarsdottir, Rachele Hendricks‐Sturrup, Mehmet Burcu   +6 more
wiley   +1 more source

Recent Advances and Constructing Strategies of Chemiluminescence‐ and Bioluminescence‐Based Photodynamic Therapy

ChemPhotoChem, EarlyView.
Photodynamic therapy (PDT) is a noninvasive therapy for cancer and many other diseases. A PDT system includes three key components: a light source, photosensitizers (PSs), and oxygen. Internal light sources, such as chemiluminescence (CL) and bioluminescence (BL), trigger PDT without external irradiation, allowing for more flexibility.
Yuqin Ge, Shuyan Xue, Zhonghua Chen
wiley   +1 more source