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The structure of pre-messenger RNA and messenger RNA from erythroid cells
1977Pre-mRNA fractions (greater than 45 S) were characterized by electron microscopy. High salt concentrations (0.2 M ammonium acetate, pH 8) yield linear molecules of different length (0.5--17 micrometer). In 10% of the molecules a compact-nonlinear contour (cn-contour) is detectable at one end.
A M, Ladhoff +3 more
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Radiation sensitivity of messenger RNA
Molecular and General Genetics MGG, 1979Messenger RNA function is inactivated by irradiation with ultraviolet light. A unit length mRNA (in bases) is 2-3 times more sensitive than a unit length of DNA (in base pairs) with respect to the inactivation of template function. These data stem from four experimental systems all of which do not repair DNA: the translation of E.
Ponta, H. +4 more
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The Decay of Bacterial Messenger RNA
1996Publisher Summary The many demonstrations that the Escherichia coli (E. coli ) rne gene product (RNase E) is involved in messenger RNA (mRNA) decay have given real impetus to the study of this unusual protein's properties and role. The recent attention given to the polyadenylylation of bacterial mRNAs and the discovery that polyadenylylation ...
George J. Murakawa, Donald P. Nierlich
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Monocistronic messenger RNA in yeast
Journal of Molecular Biology, 1973Abstract We have determined the rate of polypeptide chain synthesis on different size polysomes in yeast. The completion time for the average polypeptide chain in vivo at 23 °C is two minutes by this technique and is in good agreement with values we have determined by other independent methods.
Calvin S. McLaughlin, Nancy S. Petersen
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2018
The correct interpretation — that this RNA played the role of a messenger between the inserted phage DNA and the appearance of viral proteins in the bacterial cell — was provided by Jacob and Monod. Nevertheless, understanding regulation of important eukaryotic proteins requires that messenger RNAs (mRNAs) be isolated from higher organisms.
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The correct interpretation — that this RNA played the role of a messenger between the inserted phage DNA and the appearance of viral proteins in the bacterial cell — was provided by Jacob and Monod. Nevertheless, understanding regulation of important eukaryotic proteins requires that messenger RNAs (mRNAs) be isolated from higher organisms.
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2011
Twenty years after the seminal observation of Wolff et al. that injection of naked RNA and DNA vectors results in protein expression in vivo, messenger RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been ...
Jochen Probst +5 more
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Twenty years after the seminal observation of Wolff et al. that injection of naked RNA and DNA vectors results in protein expression in vivo, messenger RNA (mRNA) vaccines have found entry into clinical development. Through improved vector design, formulation, and delivery, mRNA, initially perceived as unstable and difficult to manipulate, has been ...
Jochen Probst +5 more
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Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction.
Science, 1992Peng Liang, A. Pardee
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Nuclear Export of Messenger RNA
2002Messenger RNAs (mRNAs) exist in the cell in dynamic association with multiple distinct proteins. The mRNA export cargo is therefore a ribonucleoprotein particle (mRNP). The most striking example of this are the Balbiani ring (BR) mRNPs of Chironomus tentans which are composed of an RNA molecule of 35–40 kb in length associated with about 500 protein ...
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