Results 51 to 60 of about 169,665 (258)

Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering.

PLoS ONE, 2019
3' downstream inhibitory stem plays a crucial role in locking rpoS mRNA 5' untranslated region in a self-inhibitory state. Here, we used optical tweezers to study the unfolding/refolding of rpoS inhibitory stem in the absence and presence of Mg2+.
Xinyao Hu, Xuanling Li, Lingna Yang, Yilin Zhu, Yunyu Shi, Yinmei Li, Haowei Wang, Qingguo Gong   +7 more
doaj   +1 more source

Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.

PLoS Pathogens, 2011
RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5' and 3' untranslated regions, antisense transcripts, and intergenic small RNA (sRNA) molecules ...
Kristine B Arnvig, Iñaki Comas, Nicholas R Thomson, Joanna Houghton, Helena I Boshoff, Nicholas J Croucher, Graham Rose, Timothy T Perkins, Julian Parkhill, Gordon Dougan, Douglas B Young   +10 more
doaj   +1 more source

Cloning and expression of porcine β1,4 N-acetylgalactosaminyl transferase encoding a new xenoreactive antigen [PDF]

, 2014
Xenograft rejection of pigs organs with an engineered mutation in the GGTA-1 gene (GTKO) remains a predominantly antibody mediated process which is directed to a variety of non-Gal protein and carbohydrate antigens.
Byrne, GW, Du, Z, Kogelberg, H, McGregor, CG, Stalboerger, P   +4 more
core   +2 more sources

Discovery of DNA viruses in wild-caught mosquitoes using small RNA high throughput sequencing.

PLoS ONE, 2011
BackgroundMosquito-borne infectious diseases pose a severe threat to public health in many areas of the world. Current methods for pathogen detection and surveillance are usually dependent on prior knowledge of the etiologic agents involved.
Maijuan Ma, Yong Huang, Zhengda Gong, Lu Zhuang, Cun Li, Hong Yang, Yigang Tong, Wei Liu, Wuchun Cao   +8 more
doaj   +1 more source

RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

Genomics, Proteomics & Bioinformatics, 2023
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control of non-small cell lung cancer (NSCLC). Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful treatment.
Boyang Shi, Ke An, Yueqin Wang, Yuhan Fei, Caixia Guo, Qiangfeng Cliff Zhang, Yun-Gui Yang, Xin Tian, Quancheng Kan   +8 more
doaj   +1 more source

Genome-wide analysis of 30 -untranslated regions supports the existence of post-transcriptional regulons controlling gene expression in trypanosomes [PDF]

, 2013
In eukaryotic cells, a group of messenger ribonucleic acids (mRNAs) encoding functionally interrelated proteins together with the trans-acting factors that coordinately modulate their expression is termed a post-transcriptional regulon, due to their ...
Agüero, Fernan Gonzalo, Carmona, Santiago Javier, de Gaudenzi, Javier Gerardo, Frasch, Alberto Carlos C.   +3 more
core   +3 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Long noncoding RNAs in prostate cancer: overview and clinical implications. [PDF]

, 2016
Prostate cancer is the second most common cause of cancer mortality among men in the United States. While many prostate cancers are indolent, an important subset of patients experiences disease recurrence after conventional therapy and progresses to ...
Feng, Felix Y, Malik, Bhavna
core   +3 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The fungal natural product azaphilone-9 binds to HuR and inhibits HuR-RNA interaction in vitro. [PDF]

PLoS ONE, 2017
The RNA-binding protein Hu antigen R (HuR) binds to AU-rich elements (ARE) in the 3'-untranslated region (UTR) of target mRNAs. The HuR-ARE interactions stabilize many oncogenic mRNAs that play important roles in tumorigenesis. Thus, small molecules that
Kawaljit Kaur, Xiaoqing Wu, James K Fields, David K Johnson, Lan Lan, Miranda Pratt, Amber D Somoza, Clay C C Wang, John Karanicolas, Berl R Oakley, Liang Xu, Roberto N De Guzman   +11 more
doaj   +1 more source