Results 31 to 40 of about 117,080 (137)

Extensive diversity in RNA termination and regulation revealed by transcriptome mapping for the Lyme pathogen Borrelia burgdorferi

Nature Communications, 2023
Transcription termination is an essential and dynamic process that can tune gene expression in response to diverse molecular signals. Yet, the genomic positions, molecular mechanisms, and regulatory consequences of termination have only been studied ...
Emily Petroni, Caroline Esnault, Daniel Tetreault, Ryan K. Dale, Gisela Storz, Philip P. Adams   +5 more
doaj   +1 more source

Molecular Basis of Encapsidation of Hepatitis C Virus Genome

Frontiers in Microbiology, 2018
Hepatitis C virus (HCV), a major etiologic agent of human liver diseases, is a positive-sense single-stranded RNA virus and is classified in the Flaviviridae family.
Guoli Shi, Tetsuro Suzuki
doaj   +1 more source

Inhibition of SARS-CoV-2 by Targeting Conserved Viral RNA Structures and Sequences

Frontiers in Chemistry, 2021
The ongoing COVID-19/Severe Acute Respiratory Syndrome CoV-2 (SARS-CoV-2) pandemic has become a significant threat to public health and has hugely impacted societies globally.
Shalakha Hegde, Zhichao Tang, Junxing Zhao, Jingxin Wang   +3 more
doaj   +1 more source

RNA Polymerase III Subunit Mutations in Genetic Diseases

Frontiers in Molecular Biosciences, 2021
RNA polymerase (Pol) III transcribes small untranslated RNAs such as 5S ribosomal RNA, transfer RNAs, and U6 small nuclear RNA. Because of the functions of these RNAs, Pol III transcription is best known for its essential contribution to RNA maturation ...
Elisabeth Lata, Karine Choquet, Francis Sagliocco, Bernard Brais, Geneviève Bernard, Geneviève Bernard, Geneviève Bernard, Martin Teichmann   +7 more
doaj   +1 more source

Reassessing the Abundance of miRNAs in the Human Pancreas and Rodent Cell Lines and Its Implication

Non-Coding RNA, 2023
miRNAs are critical for pancreas development and function. However, we found that there are discrepancies regarding pancreatic miRNA abundance in published datasets.
Guihua Sun, Meirigeng Qi, Alexis S. Kim, Elizabeth M. Lizhar, Olivia W. Sun, Ismail H. Al-Abdullah, Arthur D. Riggs   +6 more
doaj   +1 more source

Conformation and mechanical property of rpoS mRNA inhibitory stem studied by optical tweezers and X-ray scattering.

PLoS ONE, 2019
3' downstream inhibitory stem plays a crucial role in locking rpoS mRNA 5' untranslated region in a self-inhibitory state. Here, we used optical tweezers to study the unfolding/refolding of rpoS inhibitory stem in the absence and presence of Mg2+.
Xinyao Hu, Xuanling Li, Lingna Yang, Yilin Zhu, Yunyu Shi, Yinmei Li, Haowei Wang, Qingguo Gong   +7 more
doaj   +1 more source

Impact of interspecies colostrum and milk replacement on circulating sncRNA dynamics of neonatal goat kids

RNA Biology
Replacing maternal colostrum and milk with those from other species is common practice in neonatal ruminant management, but the effects on small non-coding RNA (sncRNA) transmission remain poorly understood.
Rob J. Dekker, Marielle H. van den Esker, Lars Ravesloot, Wim C. de Leeuw, Marina van Olst, Martijs J. Jonker, Timo M. Breit, Ad P. Koets   +7 more
doaj   +1 more source

Sequence-based analysis uncovers an abundance of non-coding RNA in the total transcriptome of Mycobacterium tuberculosis.

PLoS Pathogens, 2011
RNA sequencing provides a new perspective on the genome of Mycobacterium tuberculosis by revealing an extensive presence of non-coding RNA, including long 5' and 3' untranslated regions, antisense transcripts, and intergenic small RNA (sRNA) molecules ...
Kristine B Arnvig, Iñaki Comas, Nicholas R Thomson, Joanna Houghton, Helena I Boshoff, Nicholas J Croucher, Graham Rose, Timothy T Perkins, Julian Parkhill, Gordon Dougan, Douglas B Young   +10 more
doaj   +1 more source

Discovery of DNA viruses in wild-caught mosquitoes using small RNA high throughput sequencing.

PLoS ONE, 2011
BackgroundMosquito-borne infectious diseases pose a severe threat to public health in many areas of the world. Current methods for pathogen detection and surveillance are usually dependent on prior knowledge of the etiologic agents involved.
Maijuan Ma, Yong Huang, Zhengda Gong, Lu Zhuang, Cun Li, Hong Yang, Yigang Tong, Wei Liu, Wuchun Cao   +8 more
doaj   +1 more source

RNA Structural Dynamics Modulate EGFR-TKI Resistance Through Controlling YRDC Translation in NSCLC Cells

Genomics, Proteomics & Bioinformatics, 2023
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) positively affect the initial control of non-small cell lung cancer (NSCLC). Rapidly acquired resistance to EGFR-TKIs is a major hurdle in successful treatment.
Boyang Shi, Ke An, Yueqin Wang, Yuhan Fei, Caixia Guo, Qiangfeng Cliff Zhang, Yun-Gui Yang, Xin Tian, Quancheng Kan   +8 more
doaj   +1 more source